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Sobp Gene Detail
Summary
  • Symbol
    Sobp
  • Name
    sine oculis binding protein
  • Synonyms
    2900009C16Rik, 5330439J01Rik, jc, Jxc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924427
    NCBI Gene: 109205
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:42878496-43050526 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 22.89 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4077 from dbSNP Build 142
  • Strain Annotations
    29
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924427
 protein coding gene Chr10:42878484-43059144 (-)
129S1/SvImJ ENSMUSG00200008796
 protein coding gene Chr10:39783826-39937120 (-)
A/J ENSMUSG00195014959
 protein coding gene Chr10:40040943-40050542 (-)
A/J ENSMUSG00195014966
 protein coding gene Chr10:40059436-40212958 (-)
AKR/J ENSMUSG00220026582
 protein coding gene Chr10:39748660-39902161 (-)
AKR/J ENSMUSG00220026595
 protein coding gene Chr10:39730421-39739624 (-)
BALB/cJ ENSMUSG00180015897
 protein coding gene Chr10:40125332-40134529 (-)
BALB/cJ ENSMUSG00180015888
 protein coding gene Chr10:40143565-40297082 (-)
C3H/HeJ ENSMUSG00175011418
 protein coding gene Chr10:39938636-40092144 (-)
C3H/HeJ ENSMUSG00175011429
 protein coding gene Chr10:39920393-39929602 (-)
C57BL/6NJ ENSMUSG00215009440
 protein coding gene Chr10:39669498-39679101 (-)
C57BL/6NJ ENSMUSG00215009458
 protein coding gene Chr10:39687994-39841483 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015284
 protein coding gene Chr10:38417338-38594701 (-)
CAST/EiJ ENSTCUG00005025755
 protein coding gene Chr10:40136565-40293372 (-)
CBA/J ENSMUSG00210025323
 protein coding gene Chr10:39813920-39823127 (-)
CBA/J ENSMUSG00210025318
 protein coding gene Chr10:39832161-39985662 (-)
DBA/2J ENSMUSG00185007235
 protein coding gene Chr10:39966244-39975851 (-)
DBA/2J ENSMUSG00185007242
 protein coding gene Chr10:39984744-40138260 (-)
FVB/NJ ENSMUSG00205012882
 protein coding gene Chr10:39881764-39890975 (-)
FVB/NJ ENSMUSG00205012856
 protein coding gene Chr10:39900008-40053514 (-)
JF1/MsJ ENSUMUG00000024240
 protein coding gene Chr10:39769458-39945524 (-)
LP/J ENSMUSG00230005619
 protein coding gene Chr10:41773603-41926889 (-)
NOD/ShiLtJ ENSMUSG00190024907
 protein coding gene Chr10:40094579-40103778 (-)
NOD/ShiLtJ ENSMUSG00190024892
 protein coding gene Chr10:40112808-40266324 (-)
NZO/HlLtJ ENSMUSG00225016769
 protein coding gene Chr10:46077672-46231158 (-)
NZO/HlLtJ ENSMUSG00225016781
 protein coding gene Chr10:46059437-46068638 (-)
PWK/PhJ ENSLUMG00010007709
 protein coding gene Chr10:39865883-40041813 (-)
SPRET/EiJ ENSMSPG00010012590
 protein coding gene Chr10:40923539-41082161 (-)
WSB/EiJ ENSIUOG00005014246
 protein coding gene Chr10:39657063-39820695 (-)



Homology
more
  • Human Ortholog
    SOBP, sine oculis binding protein homolog
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SOBP, sine oculis binding protein homolog
  • Synonyms
    JXC1, MRAMS
  • Links
    NCBI Gene ID: 55084
    UniProt: A7XYQ1

  • Chr Location
    6q21; chr6:107490073-107661306 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit open-field hyperactivity and circling behavior from weaning. Their hearing thresholds are elevated at all frequencies; the hearing impairment does not progress over time.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    694
  • Tissues
    56
  • cDNA Data
    28
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038248 Ensembl Gene Model | MGI Sequence Detail 172031 C57BL/6J ±  kb
    transcript ENSMUST00000040275 Ensembl | MGI Sequence Detail 4980 Not Applicable  
    polypeptide ENSMUSP00000040072 Ensembl | MGI Sequence Detail 864 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 29
      Primer pair 1
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-11519, MGI:1925650, MGI:96631
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 13
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:380342 Lavi-Itzkovitz A, et al., Functional consequences of necdin nucleocytoplasmic localization. PLoS One. 2012;7(3):e33786
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory