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Mrap Gene Detail
Summary
  • Symbol
    Mrap
  • Name
    melanocortin 2 receptor accessory protein
  • Synonyms
    1110025G12Rik, C21ORF61
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924287
    NCBI Gene: 77037
  • Alliance
    genome feature page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:90535095-90546673 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 51.90 cM, cytoband C3.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    555 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924287
 protein coding gene Chr16:90535095-90546673 (+)
129S1/SvImJ ENSMUSG00200036708
 protein coding gene Chr16:87442708-87454842 (+)
A/J ENSMUSG00195027681
 protein coding gene Chr16:87220238-87231801 (+)
AKR/J ENSMUSG00220015736
 protein coding gene Chr16:87410169-87421719 (+)
BALB/cJ ENSMUSG00180013622
 protein coding gene Chr16:87293558-87305145 (+)
C3H/HeJ ENSMUSG00175015325
 protein coding gene Chr16:87631255-87642817 (+)
C57BL/6NJ ENSMUSG00215029586
 protein coding gene Chr16:87421134-87432716 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020947
 protein coding gene Chr16:85125547-85137313 (+)
CAST/EiJ ENSTCUG00005017975
 protein coding gene Chr16:86961783-86973495 (+)
CBA/J ENSMUSG00210037930
 protein coding gene Chr16:87520754-87532280 (+)
DBA/2J ENSMUSG00185033357
 protein coding gene Chr16:87479555-87491291 (+)
FVB/NJ ENSMUSG00205022210
 protein coding gene Chr16:87248523-87260103 (+)
JF1/MsJ ENSUMUG00000032534
 protein coding gene Chr16:87609312-87621073 (+)
LP/J ENSMUSG00230033638
 protein coding gene Chr16:89988495-90000316 (+)
NOD/ShiLtJ ENSMUSG00190022060
 protein coding gene Chr16:87444756-87456332 (+)
NZO/HlLtJ ENSMUSG00225030330
 protein coding gene Chr16:93123449-93135026 (+)
PWK/PhJ ENSLUMG00010012307
 protein coding gene Chr16:87244565-87256302 (+)
SPRET/EiJ ENSMSPG00010028608
 protein coding gene Chr16:88391770-88403343 (+)
WSB/EiJ ENSIUOG00005018161
 protein coding gene Chr16:87359142-87371248 (+)



Homology
more
  • Human Ortholog
    MRAP, melanocortin 2 receptor accessory protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MRAP, melanocortin 2 receptor accessory protein
  • Synonyms
    B27, C21orf61, FALP, GCCD2, MRAP1
  • Links
    NCBI Gene ID: 56246
    UniProt: Q8TCY5

  • Chr Location
    21q22.11; chr21:32291813-32314784 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Mrap mouse models; 1 with human MRAP associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    91 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit neonatal lethality associated with failure of lungs to inflate, small adrenal glands, thickened adrenal casule due to hyperplasia and glucocorticoid deficiency symptoms.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    673
  • Tissues
    29
  • cDNA Data
    34
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 77037 NCBI Gene Model | MGI Sequence Detail 11579 C57BL/6J ±  kb
    transcript NR_155757 RefSeq | MGI Sequence Detail 1267 C57BL/6  
    polypeptide Q9D159 UniProt | EBI | MGI Sequence Detail 127 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      cDNA 34

      Microarray probesets 5
    References
    more
    • Summaries
      All 123
      Developmental Gene Expression 4
      Diseases 6
      Gene Ontology 4
      Phenotypes 91
    • Earliest
      J:42265 Huang TT, et al., Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997 Aug 15;344(2):424-32
    • Latest
      J:385727 Harada K, et al., Preventing Differentiation Towards Primitive Macrophages in Stem Cells With Down Syndrome. Immunology. 2026 Mar;177(3):596-612
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory