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Ticrr Gene Detail
Summary
  • Symbol
    Ticrr
  • Name
    TOPBP1-interacting checkpoint and replication regulator
  • Synonyms
    5730590G19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924261
    NCBI Gene: 77011
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:79309944-79347896 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 45.09 cM, cytoband D2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    947 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924261
 protein coding gene Chr7:79309944-79347896 (+)
129S1/SvImJ ENSMUSG00200034715
 protein coding gene Chr7:66123418-66161572 (+)
A/J ENSMUSG00195013024
 protein coding gene Chr7:70538335-70576536 (+)
AKR/J ENSMUSG00220036945
 protein coding gene Chr7:64080351-64118545 (+)
BALB/cJ ENSMUSG00180012175
 protein coding gene Chr7:67263457-67301643 (+)
C3H/HeJ ENSMUSG00175021008
 protein coding gene Chr7:68035491-68073648 (+)
C57BL/6NJ ENSMUSG00215023382
 protein coding gene Chr7:67134798-67172755 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029882
 protein coding gene Chr7:82212033-82253182 (+)
CAST/EiJ ENSTCUG00005044404
 protein coding gene Chr7:70588487-70626470 (+)
CBA/J ENSMUSG00210023792
 protein coding gene Chr7:67886767-67924922 (+)
DBA/2J ENSMUSG00185043899
 protein coding gene Chr7:72209506-72247662 (+)
FVB/NJ ENSMUSG00205016892
 protein coding gene Chr7:67776108-67814183 (+)
JF1/MsJ ENSUMUG00000018105
 protein coding gene Chr7:76870229-76908299 (+)
LP/J ENSMUSG00230011841
 protein coding gene Chr7:78299332-78337287 (+)
NOD/ShiLtJ ENSMUSG00190016422
 protein coding gene Chr7:68028080-68066271 (+)
NZO/HlLtJ ENSMUSG00225041177
 protein coding gene Chr7:76540931-76578888 (+)
PWK/PhJ ENSLUMG00010016044
 protein coding gene Chr7:66464938-66503138 (+)
SPRET/EiJ ENSMSPG00010020566
 protein coding gene Chr7:66876384-66914951 (+)
WSB/EiJ ENSIUOG00005021226
 protein coding gene Chr7:68376395-68414341 (+)



Homology
more
  • Human Ortholog
    TICRR, TOPBP1 interacting checkpoint and replication regulator
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TICRR, TOPBP1 interacting checkpoint and replication regulator
  • Synonyms
    C15orf42, SLD3, Treslin
  • Links
    NCBI Gene ID: 90381
    UniProt: Q7Z2Z1

  • Chr Location
    15q26.1; chr15:89575469-89631056 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 3 genetic backgrounds
    1 images
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele are mostly hairless, with only a light patch of hair around the face and tail. Mice homozygous for a knock-out allele show embryonic lethality before implantation. In vitro outgrowth assays show that embryos fail to hatch from the zona pellucida and die after 3 days in culture, never forming blastocysts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    650
  • Tissues
    8
  • cDNA Data
    17
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 77011 NCBI Gene Model | MGI Sequence Detail 37953 C57BL/6J ±  kb
    transcript NM_029835 RefSeq | MGI Sequence Detail 7213 C57BL/6  
    polypeptide Q8BQ33 UniProt | EBI | MGI Sequence Detail 1889 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 17
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2679713
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 26
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory