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Scfd1 Gene Detail
Summary
  • Symbol
    Scfd1
  • Name
    Sec1 family domain containing 1
  • Synonyms
    3110021P21Rik, RA410, STXBP1L2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924233
    NCBI Gene: 76983
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:51424296-51496887 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 22.11 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2315 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924233
 protein coding gene Chr12:51424293-51496887 (+)
129S1/SvImJ ENSMUSGG00200054767
 protein coding gene Chr12:43384441-43425015 (+)
A/J ENSMUSG00195017524
 protein coding gene Chr12:45952864-46025640 (+)
AKR/J ENSMUSG00220025221
 protein coding gene Chr12:43991220-44063995 (+)
BALB/cJ ENSMUSG00180005854
 protein coding gene Chr12:44944624-45017394 (+)
C3H/HeJ ENSMUSG00175011438
 protein coding gene Chr12:48015241-48088011 (+)
C57BL/6NJ ENSMUSG00215010550
 protein coding gene Chr12:44339256-44412004 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017734
 protein coding gene Chr12:46812283-46879198 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210009200
 protein coding gene Chr12:44489655-44562423 (+)
DBA/2J ENSMUSG00185014101
 protein coding gene Chr12:46456965-46529715 (+)
FVB/NJ ENSMUSG00205013178
 protein coding gene Chr12:44279887-44352636 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230015382
 protein coding gene Chr12:53491659-53566029 (+)
NOD/ShiLtJ ENSMUSG00190015946
 protein coding gene Chr12:43479876-43552617 (+)
NZO/HlLtJ ENSMUSG00225040874
 protein coding gene Chr12:55626161-55698908 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    SCFD1, sec1 family domain containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SCFD1, sec1 family domain containing 1
  • Synonyms
    C14orf163, RA410, SLY1, SLY1P, STXBP1L2
  • Links
    NCBI Gene ID: 23256
    UniProt: Q8WVM8

  • Chr Location
    14q12; chr14:30622254-30737694 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    1 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show complete embryonic lethality prior to organogenesis. In vitro, some blastocysts fail to hatch from the zona pellucida and do not form outgrowths while others do hatch but form outgrowths with no inner cell mass and dispersed trophectoderm.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    605
  • Tissues
    1
  • cDNA Data
    81
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 76983 NCBI Gene Model | MGI Sequence Detail 72592 C57BL/6J ±  kb
    transcript NR_157117 RefSeq | MGI Sequence Detail 3170 C57BL/6  
    polypeptide Q8BRF7 UniProt | EBI | MGI Sequence Detail 639 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 81
      cDNA 81

      Microarray probesets 4
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory