Chst1 MGI Mouse Gene Detail - MGI:1924219 - carbohydrate sulfotransferase 1

Symbol

Chst1
Name

carbohydrate sulfotransferase 1
Synonyms

2610008E20Rik, C6ST, GST-1, KSGAL6ST

Feature Type

protein coding gene
IDs

MGI:1924219
NCBI Gene: 76969
Alliance

genome feature page
Transcription Start Sites

10 TSS

Sequence Map

Chr2:92430052-92445595 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 51.17 cM, cytoband D-E1
Mapping Data

3 experiments

SNPs within 2kb

314 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924219	protein coding gene	Chr2:92429978-92445597 (+)
129S1/SvImJ	ENSMUSG00200052950	protein coding gene	Chr2:89346470-89362011 (+)
A/J	ENSMUSG00195051771	protein coding gene	Chr2:89483002-89498565 (+)
AKR/J	ENSMUSG00220052415	protein coding gene	Chr2:89277803-89293395 (+)
BALB/cJ	ENSMUSG00180054643	protein coding gene	Chr2:89381174-89396719 (+)
C3H/HeJ	ENSMUSG00175053477	protein coding gene	Chr2:89642433-89658012 (+)
C57BL/6NJ	ENSMUSG00215053550	protein coding gene	Chr2:89473708-89489255 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023982	protein coding gene	Chr2:86728316-86743877 (+)
CAST/EiJ	ENSTCUG00005051880	protein coding gene	Chr2:88893355-88908949 (+)
CBA/J	ENSMUSG00210028842	protein coding gene	Chr2:89653657-89669200 (+)
DBA/2J	ENSMUSG00185056507	protein coding gene	Chr2:89377542-89393087 (+)
FVB/NJ	ENSMUSG00205051360	protein coding gene	Chr2:88664345-88679925 (+)
JF1/MsJ	ENSUMUG00000030778	protein coding gene	Chr2:89202979-89218511 (+)
LP/J	ENSMUSG00230039810	protein coding gene	Chr2:91128054-91143593 (+)
NOD/ShiLtJ	ENSMUSG00190044684	protein coding gene	Chr2:89456176-89471719 (+)
NZO/HlLtJ	ENSMUSG00225051346	protein coding gene	Chr2:99043278-99058830 (+)
PWK/PhJ	ENSLUMG00010051663	protein coding gene	Chr2:89176593-89192188 (+)
SPRET/EiJ	ENSMSPG00010052043	protein coding gene	Chr2:91150965-91154523 (+)
WSB/EiJ	ENSIUOG00005053154	protein coding gene	Chr2:89182264-89197796 (+)

Human Ortholog

CHST1, carbohydrate sulfotransferase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CHST1, carbohydrate sulfotransferase 1
Synonyms

C6ST, GST-1, KS6ST, KSGal6ST, KSST
Links

HGNC:1969

NCBI Gene ID: 8534

UniProt: O43916
Chr Location

11p11.2; chr11:45647689-45666096 (-) GRCh38

MGI Vertebrate Homology

Chst1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CHST1
Protein SuperFamily

Carbohydrate_sulfotransferase
Gene Tree

Chst1

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

3
Radiation induced

1
Targeted

5
Genomic Mutations

4 involving Chst1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

18 strains or lines available

Mice homozygous for a knock-out allele exhibit increased male sibling aggression when house together, a small decrease in the peripheral and mesenteric lymph nodes and peripheral blood and a small increase in the peripheral lymph nodes and peripheral blood.

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All GO Annotations

25
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

711
Tissues

101
cDNA Data

24
Literature Summary

9

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase chst1

ZFIN chst1

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All Sequences

42
RefSeq

10
UniProt

2
CCDS

CCDS16450.1

Ensembl

ENSMUSG00000027221 (Evidence)
NCBI Gene

76969

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027221	Ensembl Gene Model \| MGI Sequence Detail	15544	C57BL/6J	± kb
transcript	ENSMUST00000065797	Ensembl \| MGI Sequence Detail	2680	Not Applicable
polypeptide	ENSMUSP00000064246	Ensembl \| MGI Sequence Detail	411	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005469 carbohydrate sulfotransferase 1

(term hierarchy)
EC

2.8.2.-, 2.8.2.21
InterPro Domains

IPR016469 Carbohydrate sulfotransferase

IPR051135 Gal/GlcNAc/GalNAc Sulfotransferase

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR000863 Sulfotransferase domain
GlyGen

Q9EQC0 4 sites, 2 N-linked glycans (2 sites)

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All nucleic 27

cDNA 24

Primer pair 2

Other 1

Microarray probesets 4

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MGI:2139320

Summaries

All 57

Developmental Gene Expression 9

Gene Ontology 9

Phenotypes 18
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:379239 Nguyen QH, et al., Regulation of neuronal fate specification and connectivity of the thalamic reticular nucleus by the Ascl1-Isl1 transcriptional cascade. Cell Mol Life Sci. 2024 Dec 3;81(1):478

TSS for Chst1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr18954	Chr2:92430016-92430069 (+)	-9 bp
Tssr18955	Chr2:92430415-92430441 (+)	376 bp
Tssr18956	Chr2:92438652-92438661 (+)	8,605 bp
Tssr18957	Chr2:92438668-92438678 (+)	8,621 bp
Tssr18958	Chr2:92438681-92438697 (+)	8,637 bp
Tssr18959	Chr2:92439835-92439843 (+)	9,787 bp
Tssr18960	Chr2:92439845-92439861 (+)	9,801 bp
Tssr18961	Chr2:92439886-92439905 (+)	9,844 bp
Tssr18962	Chr2:92439912-92439933 (+)	9,871 bp
Tssr18963	Chr2:92439938-92439949 (+)	9,892 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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