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2700049A03Rik Gene Detail
Summary
  • Symbol
    2700049A03Rik
  • Name
    RIKEN cDNA 2700049A03 gene
  • Synonyms
    Ta3, talpid3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924217
    NCBI Gene: 76967
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:71183622-71290077 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 12, 29.39 cM, cytoband C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2632 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924217
protein coding gene Chr12:71183622-71356273 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019817
protein coding gene Chr12:70916600-71018975 (+)
A/J MGP_AJ_G0019775
protein coding gene Chr12:68268458-68371811 (+)
AKR/J MGP_AKRJ_G0019751
protein coding gene Chr12:70330154-70430714 (+)
BALB/cJ MGP_BALBcJ_G0019755
protein coding gene Chr12:68741214-68845341 (+)
C3H/HeJ MGP_C3HHeJ_G0019560
protein coding gene Chr12:70797391-70898027 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020207
protein coding gene Chr12:73171000-73279534 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017827
protein coding gene Chr12:65771148-65869581 (+)
CAST/EiJ MGP_CASTEiJ_G0019112
protein coding gene Chr12:65531815-65635512 (+)
CBA/J MGP_CBAJ_G0019530
protein coding gene Chr12:75909577-76018290 (+)
DBA/2J MGP_DBA2J_G0019646
protein coding gene Chr12:68177387-68281607 (+)
FVB/NJ MGP_FVBNJ_G0019633
protein coding gene Chr12:67058011-67157098 (+)
LP/J MGP_LPJ_G0019718
protein coding gene Chr12:70904096-71021517 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019672
protein coding gene Chr12:79124216-79228445 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020242
protein coding gene Chr12:69804334-69906608 (+)
PWK/PhJ MGP_PWKPhJ_G0018877
protein coding gene Chr12:62452677-62558823 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018672
protein coding gene Chr12:64167713-64275355 (+)
WSB/EiJ MGP_WSBEiJ_G0019163
protein coding gene Chr12:70424211-70524474 (+)



Homology
more
  • Human Ortholog
    KIAA0586, KIAA0586
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KIAA0586, KIAA0586
  • Synonyms
    JBTS23, SRTD14, Talpid3
  • Links
    NCBI Gene ID: 9786
    neXtProt AC: NX_Q9BVV6
    UniProt: Q9BVV6

  • Chr Location
    14q23.1; chr14:58427385-58562090 (+)  GRCh38

Human Diseases
more
  • Diseases
    2 with human KIAA0586 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 3 alleles in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die during organogenesis, lack cilia, and show randomized L-R patterning, face and neural tube defects, pericardial edema and hemorrhages. Mouse embryonic fibroblasts homozygous for a different null allele lack cilia and asymmetrical centriolar localization.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034601 Ensembl Gene Model | MGI Sequence Detail 106456 C57BL/6J ±  kb
    transcript ENSMUST00000149564 Ensembl | MGI Sequence Detail 5763 Not Applicable  
    polypeptide ENSMUSP00000118956 Ensembl | MGI Sequence Detail 1520 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 77
      cDNA 77

      Microarray probesets 4
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 4
      Gene Ontology 8
      Phenotypes 16
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:342332 Martinez-Heredia V, et al., Absence of the primary cilia formation gene Talpid3 impairs muscle stem cell function. Commun Biol. 2023 Nov 4;6(1):1121

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    11/19/2024
    MGI 6.24
    The Jackson Laboratory