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Ifi27l2a Gene Detail
Summary
  • Symbol
    Ifi27l2a
  • Name
    interferon, alpha-inducible protein 27 like 2A
  • Synonyms
    2310061N23Rik, Ifi27
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924183
    NCBI Gene: 76933
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:103408426-103409939 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 52.93 cM, cytoband F1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    86 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924183
 protein coding gene Chr12:103400132-103409939 (-)
129S1/SvImJ ENSMUSG00200024284
 protein coding gene Chr12:95208467-95209980 (-)
A/J ENSMUSG00195018866
 protein coding gene Chr12:97735248-97736761 (-)
AKR/J ENSMUSG00220033653
 protein coding gene Chr12:95682905-95684418 (-)
BALB/cJ ENSMUSG00180032808
 protein coding gene Chr12:96928920-96930433 (-)
C3H/HeJ ENSMUSG00175031126
 protein coding gene Chr12:99547998-99549511 (-)
C57BL/6NJ ENSMUSG00215036766
 protein coding gene Chr12:96209904-96211417 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018055
 protein coding gene Chr12:98125525-98127073 (-)
CAST/EiJ ENSTCUG00005018735
 protein coding gene Chr12:95600524-95602035 (-)
CBA/J ENSMUSG00210013884
 protein coding gene Chr12:96582283-96583796 (-)
DBA/2J ENSMUSG00185043464
 protein coding gene Chr12:98386936-98388449 (-)
FVB/NJ ENSMUSG00205017744
 protein coding gene Chr12:95600182-95601695 (-)
JF1/MsJ ENSUMUG00000014211
 protein coding gene Chr12:103119292-103120804 (-)
LP/J ENSMUSG00230029387
 protein coding gene Chr12:105473447-105474960 (-)
NOD/ShiLtJ ENSMUSG00190022817
 protein coding gene Chr12:89547664-89549177 (+)
NZO/HlLtJ ENSMUSG00225038000
 protein coding gene Chr12:107184791-107186304 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010018091
 protein coding gene Chr12:99077533-99079967 (-)
WSB/EiJ ENSIUOG00005007430
 protein coding gene Chr12:95613606-95615119 (-)



Homology
more
  • Human Ortholog
    IFI27, interferon alpha inducible protein 27
  • Vertebrate Orthologs
    8
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IFI27, interferon alpha inducible protein 27
  • Synonyms
    FAM14D, ISG12, ISG12A, P27
  • Links
    NCBI Gene ID: 3429
    UniProt: P40305

  • Chr Location
    14q32.12; chr14:94104836-94116700 (+)  GRCh38
  • Human Ortholog
    IFI27L1, interferon alpha inducible protein 27 like 1
  • Synonyms
    FAM14B, ISG12C
  • Links
    NCBI Gene ID: 122509
    UniProt: Q96BM0

  • Chr Location
    14q32.12; chr14:94081271-94103846 (+)  GRCh38
  • Human Ortholog
    IFI27L2, interferon alpha inducible protein 27 like 2
  • Synonyms
    FAM14A, ISG12B, TLH29
  • Links
    NCBI Gene ID: 83982
    UniProt: Q9H2X8

  • Chr Location
    14q32.12; chr14:94125580-94130253 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal susceptibility to infection with H1N1 or H7N7 influenza A virus, although sloughing of dead cells into bronchiolar lumen persists somewhat longer after infection than in infected controls.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    604
  • Tissues
    1
  • cDNA Data
    7
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000079017 Ensembl Gene Model | MGI Sequence Detail 1514 C57BL/6J ±  kb
    transcript ENSMUST00000055071 Ensembl | MGI Sequence Detail 463 Not Applicable  
    polypeptide ENSMUSP00000054698 Ensembl | MGI Sequence Detail 90 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000034401 interferon alpha-inducible protein 27-like protein 2A
      (term hierarchy)
    • InterPro Domains
      IPR038213 IFI6/IFI27-like domain superfamily
      IPR009311 Interferon alpha-inducible protein IFI6/IFI27-like
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 7
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 13
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:364500 Liu DH, et al., Pulmonary mitochondrial DNA release and activation of the cGAS-STING pathway in Lethal Stx12 knockout mice. Cell Commun Signal. 2025 Apr 8;23(1):174
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory