Catsper3 MGI Mouse Gene Detail - MGI:1924106 - cation channel, sperm associated 3

Symbol

Catsper3
Name

cation channel, sperm associated 3
Synonyms

4921522D01Rik

Feature Type

protein coding gene
IDs

MGI:1924106
NCBI Gene: 76856
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr13:55932381-55956811 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 30.06 cM, cytoband B2
Mapping Data

2 experiments

SNPs within 2kb

104 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924106	protein coding gene	Chr13:55932313-55971861 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020611	protein coding gene	Chr13:55289970-55318018 (+)
A/J	MGP_AJ_G0020565	protein coding gene	Chr13:53242565-53266997 (+)
AKR/J	MGP_AKRJ_G0020543	protein coding gene	Chr13:54828879-54853225 (+)
BALB/cJ	MGP_BALBcJ_G0020561	protein coding gene	Chr13:53474014-53502609 (+)
C3H/HeJ	MGP_C3HHeJ_G0020360	protein coding gene	Chr13:54628518-54658036 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020995	protein coding gene	Chr13:56952258-56978207 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018577	protein coding gene	Chr13:51176212-51200913 (+)
CAST/EiJ	MGP_CASTEiJ_G0019874	protein coding gene	Chr13:54738658-54766350 (+)
CBA/J	MGP_CBAJ_G0020320	protein coding gene	Chr13:59145299-59176368 (+)
DBA/2J	MGP_DBA2J_G0020443	protein coding gene	Chr13:52793132-52817847 (+)
FVB/NJ	MGP_FVBNJ_G0020422	protein coding gene	Chr13:52259729-52283970 (+)
LP/J	MGP_LPJ_G0020519	protein coding gene	Chr13:55541989-55569320 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020451	protein coding gene	Chr13:58595012-58620711 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021038	protein coding gene	Chr13:54399842-54428856 (+)
PWK/PhJ	MGP_PWKPhJ_G0019630	protein coding gene	Chr13:52817747-52842953 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019457	protein coding gene	Chr13:53321055-53348822 (+)
WSB/EiJ	MGP_WSBEiJ_G0019936	protein coding gene	Chr13:54765990-54792732 (+)

Human Ortholog

CATSPER3, cation channel sperm associated 3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CATSPER3, cation channel sperm associated 3
Synonyms

CACRC
Links

HGNC:20819

NCBI Gene ID: 347732

neXtProt AC: NX_Q86XQ3

UniProt: Q86XQ3
Chr Location

5q31.1; chr5:134967907-135011696 (+) GRCh38

MGI Vertebrate Homology

Catsper3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CATSPER3
Gene Tree

Catsper3

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Phenotype Summary

10 phenotypes from 4 alleles in 5 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

6
Genomic Mutations

1 involving Catsper3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for this mutation are viable and exhibit no gross physical or behavioral abnormality. Although wild-type and homozygous mutant females bred to wild-type males exhibit similar fertility, male homozygotes are infertile.

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All GO Annotations

18
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

715
Tissues

5
cDNA Data

6
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

40
RefSeq

8
UniProt

3
CCDS

CCDS26555.1, CCDS56885.1

Ensembl

ENSMUSG00000021499 (Evidence)
NCBI Gene

76856

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021499	Ensembl Gene Model \| MGI Sequence Detail	24431	C57BL/6J	± kb
transcript	ENSMUST00000021961	Ensembl \| MGI Sequence Detail	1330	Not Applicable
polypeptide	ENSMUSP00000021961	Ensembl \| MGI Sequence Detail	395	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000000671 cation channel sperm-associated protein 3

(term hierarchy)
PDB

7EEB
InterPro Domains

IPR005821 Ion transport domain

IPR027359 Voltage-dependent channel domain superfamily

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All nucleic 6

cDNA 6

Microarray probesets 2

Summaries

All 37

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 13
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:314092 Lin S, et al., Structure of a mammalian sperm cation channel complex. Nature. 2021 Jul;595(7869):746-750

TSS for Catsper3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119985	Chr13:55932371-55932377 (+)	-7 bp
Tssr119986	Chr13:55932387-55932412 (+)	19 bp
Tssr119987	Chr13:55932428-55932433 (+)	50 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23