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Ago4 Gene Detail
Summary
  • Symbol
    Ago4
  • Name
    argonaute RISC catalytic subunit 4
  • Synonyms
    5730550L01Rik, argonaute 4, Eif2c4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924100
    NCBI Gene: 76850
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:126383334-126427265 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 60.90 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1364 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924100
 protein coding gene Chr4:126383280-126427379 (-)
129S1/SvImJ ENSMUSG00200013901
 protein coding gene Chr4:119822005-119865944 (-)
A/J ENSMUSG00195029161
 protein coding gene Chr4:121156865-121200924 (-)
AKR/J ENSMUSG00220020307
 protein coding gene Chr4:120137557-120181496 (-)
BALB/cJ ENSMUSG00180040081
 protein coding gene Chr4:118795206-118839167 (-)
C3H/HeJ ENSMUSG00175023945
 protein coding gene Chr4:119807950-119851901 (-)
C57BL/6NJ ENSMUSG00215018997
 protein coding gene Chr4:121301091-121345024 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026479
 protein coding gene Chr4:116259522-116306406 (-)
CAST/EiJ ENSTCUG00005044993
 protein coding gene Chr4:120677247-120722151 (-)
CBA/J ENSMUSG00210051617
 protein coding gene Chr4:119436848-119480805 (-)
DBA/2J ENSMUSG00185041865
 protein coding gene Chr4:120969468-121013434 (-)
FVB/NJ ENSMUSG00205012921
 protein coding gene Chr4:119182335-119226328 (-)
JF1/MsJ ENSUMUG00000007584
 protein coding gene Chr4:121605732-121650481 (-)
LP/J ENSMUSG00230037654
 protein coding gene Chr4:124759666-124803598 (-)
NOD/ShiLtJ ENSMUSG00190032563
 protein coding gene Chr4:119181878-119225869 (-)
NZO/HlLtJ ENSMUSG00225014966
 protein coding gene Chr4:130665831-130709857 (-)
PWK/PhJ ENSLUMG00010041316
 protein coding gene Chr4:118640797-118686717 (-)
SPRET/EiJ ENSMSPG00010038290
 protein coding gene Chr4:120707629-120752559 (-)
WSB/EiJ ENSIUOG00005044020
 protein coding gene Chr4:119043868-119087850 (-)



Homology
more
  • Human Ortholog
    AGO4, argonaute RISC component 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AGO4, argonaute RISC component 4
  • Synonyms
    EIF2C4
  • Links
    NCBI Gene ID: 192670
    UniProt: Q9HCK5

  • Chr Location
    1p34.3; chr1:35807636-35857890 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a null mutation display oligozoospermia, decreased testis weight, premature entry into meiosis and disruption of sex body formation. However both males and females are fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    54
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    682
  • Tissues
    45
  • cDNA Data
    25
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042500 Ensembl Gene Model | MGI Sequence Detail 43932 C57BL/6J ±  kb
    transcript ENSMUST00000084289 Ensembl | MGI Sequence Detail 6537 Not Applicable  
    polypeptide ENSMUSP00000081312 Ensembl | MGI Sequence Detail 861 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 25
      Primer pair 6
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2140312
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 6
      Gene Ontology 11
      Phenotypes 15
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:390225 Carro MLM, et al., Argonaute proteins orchestrate Meiotic Sex Chromosome Inactivation and timing of the spermatogenic transcriptional program. PLoS Genet. 2026 Jun;22(6):e1012217
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory