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Dtl Gene Detail
Summary
  • Symbol
    Dtl
  • Name
    denticleless E3 ubiquitin protein ligase
  • Synonyms
    2810047L02Rik, 5730564G15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924093
    NCBI Gene: 76843
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:191269468-191307656 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 96.44 cM, cytoband H6
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    817 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924093
 protein coding gene Chr1:191269468-191307656 (-)
129S1/SvImJ ENSMUSG00200003681
 protein coding gene Chr1:189044203-189083469 (-)
A/J ENSMUSG00195007692
 protein coding gene Chr1:188631864-188671492 (-)
AKR/J ENSMUSG00220004836
 protein coding gene Chr1:187875723-187915356 (-)
BALB/cJ ENSMUSG00180017004
 protein coding gene Chr1:188697334-188736967 (-)
C3H/HeJ ENSMUSG00175021810
 protein coding gene Chr1:188885274-188924900 (-)
C57BL/6NJ ENSMUSG00215017328
 protein coding gene Chr1:188102281-188140476 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015052
 protein coding gene Chr1:181340714-181381327 (-)
CAST/EiJ ENSTCUG00005001956
 protein coding gene Chr1:186669203-186707595 (-)
CBA/J ENSMUSG00210003397
 protein coding gene Chr1:188539271-188578535 (-)
DBA/2J ENSMUSG00185009930
 protein coding gene Chr1:193152523-193191786 (-)
FVB/NJ ENSMUSG00205004090
 protein coding gene Chr1:187543361-187582991 (-)
JF1/MsJ ENSUMUG00000006339
 protein coding gene Chr1:192141581-192180087 (-)
LP/J ENSMUSG00230022973
 protein coding gene Chr1:192696144-192735769 (-)
NOD/ShiLtJ ENSMUSG00190025105
 protein coding gene Chr1:188522762-188562027 (-)
NZO/HlLtJ ENSMUSG00225015896
 protein coding gene Chr1:196449418-196488681 (-)
PWK/PhJ ENSLUMG00010006116
 protein coding gene Chr1:187371483-187410747 (-)
SPRET/EiJ ENSMSPG00010023263
 protein coding gene Chr1:190912358-190950987 (-)
WSB/EiJ ENSIUOG00005004400
 protein coding gene Chr1:187876966-187915715 (-)



Homology
more
  • Human Ortholog
    DTL, denticleless E3 ubiquitin protein ligase adapter
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DTL, denticleless E3 ubiquitin protein ligase adapter
  • Synonyms
    CDT2, DCAF2, L2DTL, RAMP
  • Links
    NCBI Gene ID: 51514
    UniProt: Q9NZJ0

  • Chr Location
    1q32.3; chr1:212035553-212107400 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutation of this gene results in very early embryonic lethality around or before E1.5. In vitro siRNA knockdown experiments show that the gene is essential cell survival and cell cycle progression to allow proper blastocyst formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    61
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    54
  • cDNA Data
    17
  • Literature Summary
    9
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 76843 NCBI Gene Model | MGI Sequence Detail 38189 C57BL/6J ±  kb
transcript NM_001305233 RefSeq | MGI Sequence Detail 4253 C57BL/6  
polypeptide Q3TLR7 UniProt | EBI | MGI Sequence Detail 729 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 23
    cDNA 20
    Primer pair 3
    Antibodies 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:1917907
References
more
  • Summaries
    All 55
    Developmental Gene Expression 9
    Gene Ontology 8
    Phenotypes 21
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:361100 Wei H, et al., DCAF2 regulates the proliferation and differentiation of mouse progenitor spermatogonia by targeting p21 and thymine DNA glycosylase. Cell Prolif. 2024 Oct;57(10):e13676
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory