Dtl MGI Mouse Gene Detail - MGI:1924093 - denticleless E3 ubiquitin protein ligase

Symbol

Dtl
Name

denticleless E3 ubiquitin protein ligase
Synonyms

2810047L02Rik, 5730564G15Rik

Feature Type

protein coding gene
IDs

MGI:1924093
NCBI Gene: 76843
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr1:191269468-191307656 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 96.44 cM, cytoband H6
Mapping Data

2 experiments

SNPs within 2kb

817 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924093	protein coding gene	Chr1:191269468-191307656 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016945	protein coding gene	Chr1:198587642-198628599 (-)
A/J	MGP_AJ_G0016924	protein coding gene	Chr1:190447143-190485174 (-)
AKR/J	MGP_AKRJ_G0016889	protein coding gene	Chr1:196106433-196146008 (-)
BALB/cJ	MGP_BALBcJ_G0016882	protein coding gene	Chr1:191127751-191165882 (-)
C3H/HeJ	MGP_C3HHeJ_G0016706	protein coding gene	Chr1:196947071-196985548 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017345	protein coding gene	Chr1:204922170-204961552 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015052	protein coding gene	Chr1:181340714-181381327 (-)
CAST/EiJ	MGP_CASTEiJ_G0016289	protein coding gene	Chr1:196532191-196572918 (-)
CBA/J	MGP_CBAJ_G0016680	protein coding gene	Chr1:212513216-212553358 (-)
DBA/2J	MGP_DBA2J_G0016786	protein coding gene	Chr1:189165724-189203638 (-)
FVB/NJ	MGP_FVBNJ_G0016782	protein coding gene	Chr1:187293732-187331372 (-)
LP/J	MGP_LPJ_G0016861	protein coding gene	Chr1:199784885-199825274 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016814	protein coding gene	Chr1:219193843-219233930 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017382	protein coding gene	Chr1:195969352-196007016 (-)
PWK/PhJ	MGP_PWKPhJ_G0016076	protein coding gene	Chr1:188457735-188497889 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015852	protein coding gene	Chr1:194972930-195010931 (-)
WSB/EiJ	MGP_WSBEiJ_G0016351	protein coding gene	Chr1:196197381-196236722 (-)

Human Ortholog

DTL, denticleless E3 ubiquitin protein ligase homolog

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DTL, denticleless E3 ubiquitin protein ligase homolog
Synonyms

CDT2, DCAF2, L2DTL, RAMP
Links

HGNC:30288

NCBI Gene ID: 51514

neXtProt AC: NX_Q9NZJ0

UniProt: Q9NZJ0
Chr Location

1q32.3; chr1:212035553-212107400 (+) GRCh38

MGI Vertebrate Homology

Dtl stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DTL
Gene Tree

Dtl

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

49
Gene trapped

43
Targeted

6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

47 strains or lines available

Mutation of this gene results in very early embryonic lethality around or before E1.5. In vitro siRNA knockdown experiments show that the gene is essential cell survival and cell cycle progression to allow proper blastocyst formation.

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All GO Annotations

45
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

839
Tissues

54
cDNA Data

17
Literature Summary

9

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dtl

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All Sequences

59
RefSeq

6
UniProt

3
CCDS

CCDS15621.1

Ensembl

ENSMUSG00000037474 (Evidence)
NCBI Gene

76843

			Length	Strain/Species	Flank
genomic	76843	NCBI Gene Model \| MGI Sequence Detail	38189	C57BL/6J	± kb
transcript	NM_001305233	RefSeq \| MGI Sequence Detail	4253	C57BL/6
polypeptide	Q3TLR7	UniProt \| EBI \| MGI Sequence Detail	729	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000006716 denticleless protein

(term hierarchy)
InterPro Domains

IPR001680 WD40 repeat

IPR019775 WD40 repeat, conserved site

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

IPR051865 WD repeat-containing CDT2 adapter protein

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All nucleic 23

cDNA 20

Primer pair 3

Microarray probesets 6

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MGI:1917907

Summaries

All 49

Developmental Gene Expression 9

Gene Ontology 7

Phenotypes 18
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:352165 Lin Y, et al., Denticleless E3 ubiquitin protein ligase (DTL) maintains the proliferation and differentiation of epidermis and hair follicles during skin development. Dev Dyn. 2024 Jul;253(7):635-647

TSS for Dtl:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr15801	Chr1:191307662-191307669 (-)	-10 bp
Tssr15800	Chr1:191307649-191307661 (-)	1 bp
Tssr15799	Chr1:191307602-191307638 (-)	36 bp
Tssr15798	Chr1:191298015-191298025 (-)	9,636 bp
Tssr15797	Chr1:191273471-191273478 (-)	34,181 bp
Tssr15796	Chr1:191273182-191273195 (-)	34,467 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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