Polr3f MGI Mouse Gene Detail - MGI:1924086 - polymerase (RNA) III (DNA directed) polypeptide F

Symbol

Polr3f
Name

polymerase (RNA) III (DNA directed) polypeptide F
Synonyms

2810411G20Rik, 3010019O03Rik, 3110032A07Rik, MGC:11656, RPC39, RPC6

Feature Type

protein coding gene
IDs

MGI:1924086
NCBI Gene: 70408
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr2:144369665-144383699 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 71.02 cM, cytoband H1
Mapping Data

5 experiments

SNPs within 2kb

246 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924086	protein coding gene	Chr2:144369638-144383915 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026587	protein coding gene	Chr2:148633882-148647765 (+)
A/J	MGP_AJ_G0026551	protein coding gene	Chr2:142615291-142629743 (+)
AKR/J	MGP_AKRJ_G0026525	protein coding gene	Chr2:146707532-146721919 (+)
BALB/cJ	MGP_BALBcJ_G0026563	protein coding gene	Chr2:143051981-143066689 (+)
C3H/HeJ	MGP_C3HHeJ_G0026306	protein coding gene	Chr2:147251597-147265839 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027008	protein coding gene	Chr2:153081742-153096056 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024385	protein coding gene	Chr2:136788693-136799883 (+)
CAST/EiJ	MGP_CASTEiJ_G0025767	protein coding gene	Chr2:147587044-147600411 (+)
CBA/J	MGP_CBAJ_G0026286	protein coding gene	Chr2:158670407-158684717 (+)
DBA/2J	MGP_DBA2J_G0026420	protein coding gene	Chr2:141895485-141909367 (+)
FVB/NJ	MGP_FVBNJ_G0026384	protein coding gene	Chr2:140475726-140486870 (+)
LP/J	MGP_LPJ_G0026524	protein coding gene	Chr2:148780814-148795672 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026404	protein coding gene	Chr2:162858647-162875319 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027063	protein coding gene	Chr2:146699242-146713153 (+)
PWK/PhJ	MGP_PWKPhJ_G0025503	protein coding gene	Chr2:141558127-141572182 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025304	protein coding gene	Chr2:145747203-145758324 (+)
WSB/EiJ	MGP_WSBEiJ_G0025840	protein coding gene	Chr2:147712195-147723322 (+)

Human Ortholog

POLR3F, RNA polymerase III subunit F

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

POLR3F, RNA polymerase III subunit F
Synonyms

C34, IMD101, RPC39, RPC6
Links

HGNC:15763

NCBI Gene ID: 10621

neXtProt AC: NX_Q9H1D9

UniProt: Q9H1D9
Chr Location

20p11.23; chr20:18466878-18484648 (+) GRCh38

MGI Vertebrate Homology

Polr3f stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: POLR3F
Protein SuperFamily

RNA_pol_Rpc34
Gene Tree

Polr3f

Diseases

1 with human POLR3F associations

				Human Disease	Mouse Models
				primary immunodeficiency disease IDs primary immunodeficiency disease DOID:612 ICD10CM:D84.9 ICD9CM:279.3 KEGG:05340 MESH:D007153 NCI:C39725 OMIM:242850 OMIM:PS300755 UMLS_CUI:C0021051

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Polr3f
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

18 strains or lines available

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All GO Annotations

14
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

806
Tissues

95
cDNA Data

17
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase polr3f

ZFIN polr3f

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All Sequences

54
RefSeq

2
UniProt

3
CCDS

CCDS16820.1

Ensembl

ENSMUSG00000027427 (Evidence)
NCBI Gene

70408

			Length	Strain/Species	Flank
genomic	70408	NCBI Gene Model \| MGI Sequence Detail	14035	C57BL/6J	± kb
transcript	NM_029763	RefSeq \| MGI Sequence Detail	4160	C57BL/6
polypeptide	Q921X6	UniProt \| EBI \| MGI Sequence Detail	316	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000013005 DNA-directed RNA polymerase III subunit RPC6

(term hierarchy)
PDB

2DK8
InterPro Domains

IPR007832 RNA polymerase Rpc34

IPR016049 RNA polymerase Rpc34-like

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily

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All nucleic 20

cDNA 20

Microarray probesets 9

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MGI:1917658, MGI:1920386

Summaries

All 46

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 9
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:274872 Ingham NJ, et al., Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS Biol. 2019 Apr;17(4):e3000194

TSS for Polr3f:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20540	Chr2:144369435-144369447 (+)	-224 bp
Tssr20541	Chr2:144369658-144369693 (+)	11 bp
Tssr20542	Chr2:144369711-144369722 (+)	52 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23