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Dok5 Gene Detail
Summary
  • Symbol
    Dok5
  • Name
    docking protein 5
  • Synonyms
    2700055C10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924079
    NCBI Gene: 76829
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
  • Regulated by
    Rr695534 (1 regulatory region)
Location &
Maps
more
  • Sequence Map
    Chr2:170573727-170721689 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 92.26 cM, cytoband H3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5096 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924079
 protein coding gene Chr2:170573722-170721695 (+)
129S1/SvImJ ENSMUSG00200039882
 protein coding gene Chr2:167482633-167631551 (+)
A/J ENSMUSG00195023547
 protein coding gene Chr2:167834615-167983568 (+)
AKR/J ENSMUSG00220033522
 protein coding gene Chr2:167126850-167275811 (+)
BALB/cJ ENSMUSG00180036341
 protein coding gene Chr2:167273888-167422822 (+)
C3H/HeJ ENSMUSG00175038256
 protein coding gene Chr2:168046391-168195331 (+)
C57BL/6NJ ENSMUSG00215026486
 protein coding gene Chr2:167457081-167606025 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024731
 protein coding gene Chr2:162710463-162861275 (+)
CAST/EiJ ENSTCUG00005008290
 protein coding gene Chr2:166369472-166526150 (+)
CBA/J ENSMUSG00210036290
 protein coding gene Chr2:167954014-168102939 (+)
DBA/2J ENSMUSG00185025139
 protein coding gene Chr2:167667919-167816845 (+)
FVB/NJ ENSMUSG00205019379
 protein coding gene Chr2:166708693-166857373 (+)
JF1/MsJ ENSUMUG00000027453
 protein coding gene Chr2:167362529-167513460 (+)
LP/J ENSMUSG00230011443
 protein coding gene Chr2:169243055-169391979 (+)
NOD/ShiLtJ ENSMUSG00190027714
 protein coding gene Chr2:167361090-167510019 (+)
NZO/HlLtJ ENSMUSG00225002666
 protein coding gene Chr2:177230174-177379096 (+)
PWK/PhJ ENSLUMG00010032829
 protein coding gene Chr2:167250658-167401478 (+)
SPRET/EiJ ENSMSPG00010024361
 protein coding gene Chr2:169987118-170136987 (+)
WSB/EiJ ENSIUOG00005021993
 protein coding gene Chr2:167079243-167228349 (+)



Homology
more
  • Human Ortholog
    DOK5, docking protein 5
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DOK5, docking protein 5
  • Synonyms
    C20orf180, IRS-6, IRS6
  • Links
    NCBI Gene ID: 55816
    UniProt: Q9P104

  • Chr Location
    20q13.2; chr20:54475593-54651171 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    679
  • Tissues
    71
  • cDNA Data
    10
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027560 Ensembl Gene Model | MGI Sequence Detail 147963 C57BL/6J ±  kb
transcript ENSMUST00000029075 Ensembl | MGI Sequence Detail 1768 Not Applicable  
polypeptide ENSMUSP00000029075 Ensembl | MGI Sequence Detail 306 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 10
    Primer pair 2
    Antibodies 3

    Microarray probesets 2
References
more
  • Summaries
    All 33
    Developmental Gene Expression 6
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory