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Mtfr1l Gene Detail
Summary
  • Symbol
    Mtfr1l
  • Name
    mitochondrial fission regulator 1-like
  • Synonyms
    2410166I05Rik, Fam54b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924074
    NCBI Gene: 76824
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:134252866-134262698 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 66.83 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    321 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924074
 protein coding gene Chr4:134252861-134262698 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028930
 protein coding gene Chr4:136886871-136896794 (-)
A/J MGP_AJ_G0028889
 protein coding gene Chr4:131129068-131138885 (-)
AKR/J MGP_AKRJ_G0028841
 protein coding gene Chr4:134893555-134904293 (-)
BALB/cJ MGP_BALBcJ_G0028913
 protein coding gene Chr4:131776818-131786625 (-)
C3H/HeJ MGP_C3HHeJ_G0028627
 protein coding gene Chr4:135138019-135147816 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029354
 protein coding gene Chr4:141823837-141835940 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026625
 protein coding gene Chr4:124184994-124194575 (-)
CAST/EiJ MGP_CASTEiJ_G0028059
 protein coding gene Chr4:133254735-133264577 (-)
CBA/J MGP_CBAJ_G0028592
 protein coding gene Chr4:145570226-145580028 (-)
DBA/2J MGP_DBA2J_G0028741
 protein coding gene Chr4:131550099-131559905 (-)
FVB/NJ MGP_FVBNJ_G0028708
 protein coding gene Chr4:130446250-130456359 (-)
LP/J MGP_LPJ_G0028840
 protein coding gene Chr4:136998930-137008790 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028734
 protein coding gene Chr4:150042852-150052644 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029392
 protein coding gene Chr4:135326273-135341969 (-)
PWK/PhJ MGP_PWKPhJ_G0027779
 protein coding gene Chr4:128281228-128291237 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027605
 protein coding gene Chr4:131145258-131155125 (-)
WSB/EiJ MGP_WSBEiJ_G0028137
 protein coding gene Chr4:135494960-135504762 (-)



Homology
more
  • Human Ortholog
    MTFR1L, mitochondrial fission regulator 1 like
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MTFR1L, mitochondrial fission regulator 1 like
  • Synonyms
    FAM54B, HYST1888, MST116, MSTP116
  • Links
    NCBI Gene ID: 56181
    UniProt: Q9H019

  • Chr Location
    1p36.11; chr1:25818640-25832947 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit altered Parkin abundance in the heart, impaired stress-induced cardiac mitophagy, increased mitochondrial damage, and accelerated age-related cardiac dysfunction, inflammation, and cellular senescence.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    4
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    164
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 76824 NCBI Gene Model | MGI Sequence Detail 9833 C57BL/6J ±  kb
    transcript NM_001355188 RefSeq | MGI Sequence Detail 2223 C57BL/6  
    polypeptide Q9CWE0 UniProt | EBI | MGI Sequence Detail 289 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000029478 protein FAM54B
      (term hierarchy)
    • InterPro Domains
      IPR007972 Mitochondrial fission regulator 1
    • GlyGen
      Q9CWE0 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 164
      cDNA 164

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2140307
    References
    more
    • Summaries
      All 39
      Gene Ontology 4
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:390197 Shi L, et al., MTFR1L is a cardiac antiaging factor for maintenance of mitochondrial homeostasis. Proc Natl Acad Sci U S A. 2026 Jan 27;123(4):e2527247123
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    07/14/2026
    MGI 6.24     		The Jackson Laboratory