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Usp42 Gene Detail
Summary
  • Symbol
    Usp42
  • Name
    ubiquitin specific peptidase 42
  • Synonyms
    2410140K03Rik, 3110031A07Rik, A630018G05Rik, D5Ertd591e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924050
    NCBI Gene: 76800
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:143696080-143718035 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 82.50 cM, cytoband G2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    461 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924050
 protein coding gene Chr5:143696077-143741600 (-)
129S1/SvImJ ENSMUSG00200039069
 protein coding gene Chr5:137558829-137580803 (-)
A/J ENSMUSG00195043307
 protein coding gene Chr5:137208680-137230662 (-)
AKR/J ENSMUSG00220022384
 protein coding gene Chr5:136436328-136458305 (-)
BALB/cJ ENSMUSG00180030084
 protein coding gene Chr5:137310676-137332661 (-)
C3H/HeJ ENSMUSG00175039133
 protein coding gene Chr5:139236174-139258154 (-)
C57BL/6NJ ENSMUSG00215040432
 protein coding gene Chr5:137145012-137166966 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027985
 protein coding gene Chr5:136430566-136452978 (-)
CAST/EiJ ENSTCUG00005027196
 protein coding gene Chr5:136588348-136610294 (-)
CBA/J ENSMUSG00210023669
 protein coding gene Chr5:138043394-138065375 (-)
DBA/2J ENSMUSG00185050818
 protein coding gene Chr5:141037878-141059861 (-)
FVB/NJ ENSMUSG00205034193
 protein coding gene Chr5:136862391-136884372 (-)
JF1/MsJ ENSUMUG00000037745
 protein coding gene Chr5:143915244-143937263 (-)
LP/J ENSMUSG00230023532
 protein coding gene Chr5:145162569-145184543 (-)
NOD/ShiLtJ ENSMUSG00190032235
 protein coding gene Chr5:137001114-137023093 (-)
NZO/HlLtJ ENSMUSG00225007706
 protein coding gene Chr5:152635380-152657365 (-)
PWK/PhJ ENSLUMG00010018689
 protein coding gene Chr5:135622325-135644303 (-)
SPRET/EiJ ENSMSPG00010028307
 protein coding gene Chr5:139232618-139253019 (-)
WSB/EiJ ENSIUOG00005031936
 protein coding gene Chr5:139526903-139548877 (-)



Homology
more
  • Human Ortholog
    USP42, ubiquitin specific peptidase 42
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USP42, ubiquitin specific peptidase 42
  • Links
    NCBI Gene ID: 84132
    UniProt: Q9H9J4

  • Chr Location
    7p22.1; chr7:6081241-6161565 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 1 allele in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit fecundity and behavioral abnormalities, hyperactivity, increased T cell number, abnormal lens morphology, and cataracts. Males display oligozoospermia and testis degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    656
  • Tissues
    44
  • cDNA Data
    86
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000051306 Ensembl Gene Model | MGI Sequence Detail 21956 C57BL/6J ±  kb
    transcript ENSMUST00000053287 Ensembl | MGI Sequence Detail 5151 Not Applicable  
    polypeptide ENSMUSP00000053955 Ensembl | MGI Sequence Detail 1324 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000017181 ubiquitin carboxyl-terminal hydrolase 42
      (term hierarchy)
    • EC
      3.4.19.12
    • InterPro Domains
      IPR038765 Papain-like cysteine peptidase superfamily
      IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
      IPR050164 Ubiquitin carboxyl-terminal hydrolases
      IPR018200 Ubiquitin specific protease, conserved site
      IPR028889 Ubiquitin specific protease USP, catalytic domain
    Molecular
    Reagents
    less
    • All nucleic 87
      cDNA 86
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1261892, MGI:1920429, MGI:2444457
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 10
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory