Dapl1 MGI Mouse Gene Detail - MGI:1923997 - death associated protein-like 1

Symbol

Dapl1
Name

death associated protein-like 1
Synonyms

2310032F03Rik, EEDA

Feature Type

protein coding gene
IDs

MGI:1923997
NCBI Gene: 76747
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr2:59314997-59335364 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 33.81 cM, cytoband C3
Mapping Data

2 experiments

SNPs within 2kb

208 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923997	protein coding gene	Chr2:59314997-59335364 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025755	protein coding gene	Chr2:59021213-59043087 (+)
A/J	MGP_AJ_G0025731	protein coding gene	Chr2:56740661-56761858 (+)
AKR/J	MGP_AKRJ_G0025701	protein coding gene	Chr2:58303216-58323574 (+)
BALB/cJ	MGP_BALBcJ_G0025726	protein coding gene	Chr2:56851555-56872233 (+)
C3H/HeJ	MGP_C3HHeJ_G0025487	protein coding gene	Chr2:58411189-58431966 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026173	protein coding gene	Chr2:60786378-60807741 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023577	protein coding gene	Chr2:54335015-54355708 (+)
CAST/EiJ	MGP_CASTEiJ_G0024951	protein coding gene	Chr2:58441732-58461535 (+)
CBA/J	MGP_CBAJ_G0025467	protein coding gene	Chr2:63082090-63106628 (+)
DBA/2J	MGP_DBA2J_G0025598	protein coding gene	Chr2:56359150-56379725 (+)
FVB/NJ	MGP_FVBNJ_G0025560	protein coding gene	Chr2:55890546-55911238 (+)
LP/J	MGP_LPJ_G0025686	protein coding gene	Chr2:58875169-58898026 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025591	protein coding gene	Chr2:64716887-64738628 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026230	protein coding gene	Chr2:58334426-58354910 (+)
PWK/PhJ	MGP_PWKPhJ_G0024692	protein coding gene	Chr2:56192982-56214526 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024499	protein coding gene	Chr2:58407508-58427799 (+)
WSB/EiJ	MGP_WSBEiJ_G0025019	protein coding gene	Chr2:58627741-58650723 (+)

Human Ortholog

DAPL1, death associated protein like 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DAPL1, death associated protein like 1
Links

HGNC:21490

NCBI Gene ID: 92196

neXtProt AC: NX_A0PJW8

UniProt: A0PJW8
Chr Location

2q24.1; chr2:158795317-158862781 (+) GRCh38

MGI Vertebrate Homology

Dapl1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DAPL1
Gene Tree

Dapl1

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

6
Genomic Mutations

1 involving Dapl1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit increased proliferation of retinal pigment epithelial cells forming multiple layers.

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All GO Annotations

10
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

777
Tissues

31
cDNA Data

25
Literature Summary

4

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dapl1

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All Sequences

36
RefSeq

2
UniProt

1
CCDS

CCDS16053.1

Ensembl

ENSMUSG00000026989 (Evidence)
NCBI Gene

76747

			Length	Strain/Species	Flank
genomic	76747	NCBI Gene Model \| MGI Sequence Detail	20368	C57BL/6J	± kb
transcript	NM_029723	RefSeq \| MGI Sequence Detail	589	C57BL/6
polypeptide	Q9D757	UniProt \| EBI \| MGI Sequence Detail	107	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000006279 death-associated protein-like 1

(term hierarchy)
InterPro Domains

IPR024130 DAP1/DAPL1

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All nucleic 29

cDNA 25

Primer pair 3

Other 1

Microarray probesets 5

Summaries

All 36

Developmental Gene Expression 4

Gene Ontology 4

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:333979 Zhu L, et al., Dapl1 controls NFATc2 activation to regulate CD8(+) T cell exhaustion and responses in chronic infection and cancer. Nat Cell Biol. 2022 Jul;24(7):1165-1176

TSS for Dapl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr17858	Chr2:59314989-59315007 (+)	1 bp
Tssr17859	Chr2:59335199-59335202 (+)	20,204 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23