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Elapor1 Gene Detail
Summary
  • Symbol
    Elapor1
  • Name
    endosome-lysosome associated apoptosis and autophagy regulator 1
  • Synonyms
    5330417C22Rik, Iir, Inceptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923930
    NCBI Gene: 229722
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:108363010-108443852 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 47.14 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2694 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923930
 protein coding gene Chr3:108362995-108444064 (-)
129S1/SvImJ ENSMUSG00200035550
 protein coding gene Chr3:104979029-105060075 (-)
A/J ENSMUSG00195025198
 protein coding gene Chr3:105405480-105486548 (-)
AKR/J ENSMUSG00220026901
 protein coding gene Chr3:103769127-103850182 (-)
BALB/cJ ENSMUSG00180016610
 protein coding gene Chr3:105351575-105432646 (-)
C3H/HeJ ENSMUSG00175027597
 protein coding gene Chr3:104885577-104966614 (-)
C57BL/6NJ ENSMUSG00215024405
 protein coding gene Chr3:105613461-105694522 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025532
 protein coding gene Chr3:102664382-102738324 (-)
CAST/EiJ ENSTCUG00005024135
 protein coding gene Chr3:105888109-105968628 (-)
CBA/J ENSMUSG00210008385
 protein coding gene Chr3:105507454-105588507 (-)
DBA/2J ENSMUSG00185021357
 protein coding gene Chr3:105976796-106057845 (-)
FVB/NJ ENSMUSG00205017555
 protein coding gene Chr3:104543462-104624539 (-)
JF1/MsJ ENSUMUG00000004477
 protein coding gene Chr3:104950503-105035978 (-)
LP/J ENSMUSG00230018507
 protein coding gene Chr3:107892016-107973058 (-)
NOD/ShiLtJ ENSMUSG00190029871
 protein coding gene Chr3:106214874-106295939 (-)
NZO/HlLtJ ENSMUSG00225018806
 protein coding gene Chr3:110393866-110482631 (-)
PWK/PhJ ENSLUMG00010023919
 protein coding gene Chr3:104813840-104891644 (-)
SPRET/EiJ ENSMSPG00010029798
 protein coding gene Chr3:105318662-105396552 (-)
WSB/EiJ ENSIUOG00005004088
 protein coding gene Chr3:105531151-105611021 (-)



Homology
more
  • Human Ortholog
    ELAPOR1, endosome-lysosome associated apoptosis and autophagy regulator 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ELAPOR1, endosome-lysosome associated apoptosis and autophagy regulator 1
  • Synonyms
    EIG121, KIAA1324
  • Links
    NCBI Gene ID: 57535
    UniProt: Q6UXG2

  • Chr Location
    1p13.3; chr1:109113175-109206781 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male homozygous mice are infertile. Microscopic analysis revealed defective spermatogenesis in the testis, and hypospermia and defective spermatozoa in the epididymides.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    32
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040412 Ensembl Gene Model | MGI Sequence Detail 80843 C57BL/6J ±  kb
    transcript ENSMUST00000106625 Ensembl | MGI Sequence Detail 5836 Not Applicable  
    polypeptide ENSMUSP00000102236 Ensembl | MGI Sequence Detail 1013 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000060179 endosome/lysosome-associated apoptosis and autophagy regulator 1
      (term hierarchy)
    • PDB
      9VQL, 9VQM
    • InterPro Domains
      IPR056606 Elapor1/2, C-terminal domain
      IPR056608 Elapor1/2, galactose binding domain
      IPR056607 Elapor1/2, mannose 6-phosphate receptor homology domain
      IPR056610 Elapor1/2, TNF receptor-like
      IPR056609 Elapor1-like, galactose binding domain
      IPR039181 Endosome/lysosome-associated apoptosis and autophagy regulator family member 1/2
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR009011 Mannose-6-phosphate receptor binding domain superfamily
      IPR044865 MRH domain
    • GlyGen
      A2AFS3 5 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 32

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2140031, MGI:6393872
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 4
      Phenotypes 21
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory