About   Help   FAQ
Wfdc3 Gene Detail
Summary
  • Symbol
    Wfdc3
  • Name
    WAP four-disulfide core domain 3
  • Synonyms
    1700015L13Rik, 1700127F16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923897
    NCBI Gene: 71856
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:164573222-164587914 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 85.27 cM, cytoband H3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    953 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923897
 protein coding gene Chr2:164573100-164587914 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026869
 protein coding gene Chr2:170224335-170240411 (-)
A/J MGP_AJ_G0026836
 protein coding gene Chr2:163268108-163282861 (-)
AKR/J MGP_AKRJ_G0026807
 protein coding gene Chr2:168123943-168138635 (-)
BALB/cJ MGP_BALBcJ_G0026845
 protein coding gene Chr2:163627543-163642299 (-)
C3H/HeJ MGP_C3HHeJ_G0026587
 protein coding gene Chr2:168483887-168499368 (-)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0024663
 protein coding gene Chr2:156676386-156691939 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0026564
 protein coding gene Chr2:181513567-181528318 (-)
DBA/2J MGP_DBA2J_G0026702
 protein coding gene Chr2:162435265-162449897 (-)
FVB/NJ MGP_FVBNJ_G0026668
 protein coding gene Chr2:160855698-160870651 (-)
LP/J MGP_LPJ_G0026804
 protein coding gene Chr2:170286587-170301103 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0027349
 protein coding gene Chr2:168025088-168039667 (-)
PWK/PhJ MGP_PWKPhJ_G0025782
 protein coding gene Chr2:162034210-162049886 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025583
 protein coding gene Chr2:166929286-166944130 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    WFDC3, WAP four-disulfide core domain 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WFDC3, WAP four-disulfide core domain 3
  • Synonyms
    dJ447F3.3, WAP14
  • Links
    NCBI Gene ID: 140686
    neXtProt AC: NX_Q8IUB2
    UniProt: Q8IUB2

  • Chr Location
    20q13.12; chr20:45747944-45791932 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    723
  • Tissues
    14
  • cDNA Data
    6
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 71856 NCBI Gene Model | MGI Sequence Detail 14693 C57BL/6J ±  kb
transcript NR_184810 RefSeq | MGI Sequence Detail 1631 C57BL/6  
polypeptide Q14AE4 UniProt | EBI | MGI Sequence Detail 130 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR036645 Elafin-like superfamily
    IPR050514 WAP four-disulfide core domain
    IPR008197 WAP-type 'four-disulfide core' domain
  • GlyGen
    Q14AE4 1 site
Molecular
Reagents
less
  • All nucleic 8
    cDNA 6
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:1919106
References
more
  • Summaries
    All 33
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:326355 Bademci G, et al., Mutations in MINAR2 encoding membrane integral NOTCH2-associated receptor 2 cause deafness in humans and mice. Proc Natl Acad Sci U S A. 2022 Jun 28;119(26):e2204084119
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory