Lrrc27 Gene Detail

Summary

• Symbol
  Lrrc27
• Name
  leucine rich repeat containing 27
• Synonyms
  1700071K18Rik, 2310044E02Rik

• Feature Type
  protein coding gene
• IDs
  MGI:1923862
  NCBI Gene: 76612
• Alliance
  gene page
• Transcription Start Sites
  14 TSS

Location &
Maps

• Sequence Map
  Chr7:138792904-138822895 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 7, 84.30 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  1439 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923862	protein coding gene	Chr7:138791548-138822895 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033148	protein coding gene	Chr7:144216277-144254179 (+)
A/J	MGP_AJ_G0033130	protein coding gene	Chr7:140148551-140178558 (+)
AKR/J	MGP_AKRJ_G0033062	protein coding gene	Chr7:143921341-143957017 (+)
BALB/cJ	MGP_BALBcJ_G0033131	protein coding gene	Chr7:139889947-139920753 (+)
C3H/HeJ	MGP_C3HHeJ_G0032845	protein coding gene	Chr7:143735951-143775491 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033642	protein coding gene	Chr7:149533272-149575991 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030615	protein coding gene	Chr7:141287194-141318682 (+)
CAST/EiJ	MGP_CASTEiJ_G0032175	protein coding gene	Chr7:136025034-136064421 (+)
CBA/J	MGP_CBAJ_G0032818	protein coding gene	Chr7:154584762-154627887 (+)
DBA/2J	MGP_DBA2J_G0032970	protein coding gene	Chr7:138105642-138137599 (+)
FVB/NJ	MGP_FVBNJ_G0032923	protein coding gene	Chr7:137989865-138021686 (+)
LP/J	MGP_LPJ_G0033064	protein coding gene	Chr7:145754860-145798658 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032955	protein coding gene	Chr7:155296028-155333006 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033662	protein coding gene	Chr7:142919608-142961020 (+)
PWK/PhJ	MGP_PWKPhJ_G0031881	protein coding gene	Chr7:131276379-131308386 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031726	protein coding gene	Chr7:129760040-129793099 (+)
WSB/EiJ	MGP_WSBEiJ_G0032286	protein coding gene	Chr7:143837821-143874727 (+)

Homology

• Human Ortholog
  LRRC27, leucine rich repeat containing 27

• Vertebrate Orthologs
  2

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  LRRC27, leucine rich repeat containing 27
  
• Links
  HGNC:29346

  NCBI Gene ID: 80313

  UniProt: Q9C0I9

  
  
• Chr Location
  10q26.3; chr10:132330063-132381508 (+)  GRCh38

---

• MGI Vertebrate Homology
  Lrrc27 stringent orthology
  1 human;1 mouse;1 rat
  
• HCOP
  vertebrate homology predictions: LRRC27
• Gene Tree
  Lrrc27
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  3 phenotype references
  

• All Mutations and Alleles
  22
• Gene trapped
  21
• Targeted
  1
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  30 strains or lines available

Gene Ontology
(GO)
Classifications

Expression

• Assay Results
  706
• cDNA Data
  30

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase lrrc27

Sequences &
Gene Models

• All Sequences
  79
• RefSeq
  34
• UniProt
  4
• CCDS
  CCDS21953.1, CCDS52426.1

• Ensembl
  ENSMUSG00000015980 (Evidence)
• NCBI Gene
  76612

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000015980	Ensembl Gene Model | MGI Sequence Detail	29992	C57BL/6J
transcript	ENSMUST00000016124	Ensembl | MGI Sequence Detail	2113	Not Applicable
polypeptide	ENSMUSP00000016124	Ensembl | MGI Sequence Detail	523	Not Applicable

Protein
Information

• UniProt
  4 Sequences
• Protein Ontology
  PR:000031697 leucine-rich repeat-containing protein 27
  (term hierarchy)
• InterPro Domains
  IPR001611 Leucine-rich repeat
  IPR050216 Leucine-rich repeat domain-containing protein
  IPR032675 Leucine-rich repeat domain superfamily
  IPR003591 Leucine-rich repeat, typical subtype

Molecular
Reagents

• All nucleic 30

  cDNA 30

  
  

  Microarray probesets 5

Other
Accession IDs

MGI:1916930

References

• Summaries
  All 21

  Phenotypes 3
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563

TSS for Lrrc27:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr69696	Chr7:138792890-138792909 (+)	-4 bp
Tssr69697	Chr7:138792919-138792932 (+)	22 bp
Tssr69698	Chr7:138793155-138793220 (+)	284 bp
Tssr69699	Chr7:138793225-138793236 (+)	327 bp
Tssr69700	Chr7:138793296-138793327 (+)	408 bp
Tssr69701	Chr7:138793409-138793428 (+)	515 bp
Tssr69702	Chr7:138794577-138794597 (+)	1,683 bp
Tssr69703	Chr7:138794599-138794625 (+)	1,708 bp
Tssr69704	Chr7:138794626-138794638 (+)	1,728 bp
Tssr69705	Chr7:138794639-138794649 (+)	1,740 bp
Tssr69706	Chr7:138800490-138800535 (+)	7,609 bp
Tssr69707	Chr7:138804892-138804901 (+)	11,993 bp
Tssr69708	Chr7:138815761-138815772 (+)	22,863 bp
Tssr69709	Chr7:138815777-138815794 (+)	22,882 bp