Lrrc27 MGI Mouse Gene Detail - MGI:1923862 - leucine rich repeat containing 27

Symbol

Lrrc27
Name

leucine rich repeat containing 27
Synonyms

1700071K18Rik, 2310044E02Rik

Feature Type

protein coding gene
IDs

MGI:1923862
NCBI Gene: 76612
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr7:138792904-138822895 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 84.30 cM
Mapping Data

1 experiment

SNPs within 2kb

342 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923862	protein coding gene	Chr7:138791548-138822895 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033148	protein coding gene	Chr7:144216277-144254179 (+)
A/J	MGP_AJ_G0033130	protein coding gene	Chr7:140148551-140178558 (+)
AKR/J	MGP_AKRJ_G0033062	protein coding gene	Chr7:143921341-143957017 (+)
BALB/cJ	MGP_BALBcJ_G0033131	protein coding gene	Chr7:139889947-139920753 (+)
C3H/HeJ	MGP_C3HHeJ_G0032845	protein coding gene	Chr7:143735951-143775491 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033642	protein coding gene	Chr7:149533272-149575991 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030615	protein coding gene	Chr7:141287194-141318682 (+)
CAST/EiJ	MGP_CASTEiJ_G0032175	protein coding gene	Chr7:136025034-136064421 (+)
CBA/J	MGP_CBAJ_G0032818	protein coding gene	Chr7:154584762-154627887 (+)
DBA/2J	MGP_DBA2J_G0032970	protein coding gene	Chr7:138105642-138137599 (+)
FVB/NJ	MGP_FVBNJ_G0032923	protein coding gene	Chr7:137989865-138021686 (+)
LP/J	MGP_LPJ_G0033064	protein coding gene	Chr7:145754860-145798658 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032955	protein coding gene	Chr7:155296028-155333006 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033662	protein coding gene	Chr7:142919608-142961020 (+)
PWK/PhJ	MGP_PWKPhJ_G0031881	protein coding gene	Chr7:131276379-131308386 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031726	protein coding gene	Chr7:129760040-129793099 (+)
WSB/EiJ	MGP_WSBEiJ_G0032286	protein coding gene	Chr7:143837821-143874727 (+)

Human Ortholog

LRRC27, leucine rich repeat containing 27

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LRRC27, leucine rich repeat containing 27
Links

HGNC:29346

NCBI Gene ID: 80313

neXtProt AC: NX_Q9C0I9

UniProt: Q9C0I9
Chr Location

10q26.3; chr10:132330063-132381508 (+) GRCh38

Alliance of Genome Resources

Lrrc27 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: LRRC27
Gene Tree

Lrrc27

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Phenotype Summary

3 phenotype references

All Mutations and Alleles

22
Gene trapped

21
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

18 strains or lines available

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All GO Annotations

4
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

30

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lrrc27

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Lrrc27 interacts with 90 markers (Mir15a, Mir16-1, Mir16-2, ...) View All

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All Sequences

79
RefSeq

34
UniProt

4
CCDS

CCDS21953.1, CCDS52426.1

Ensembl

ENSMUSG00000015980 (Evidence)
NCBI Gene

76612

			Length	Strain/Species	Flank
genomic	ENSMUSG00000015980	Ensembl Gene Model \| MGI Sequence Detail	29992	C57BL/6J	± kb
transcript	ENSMUST00000016124	Ensembl \| MGI Sequence Detail	2113	Not Applicable
polypeptide	ENSMUSP00000016124	Ensembl \| MGI Sequence Detail	523	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000031697 leucine-rich repeat-containing protein 27

(term hierarchy)
InterPro Domains

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR003591 Leucine-rich repeat, typical subtype

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All nucleic 30

cDNA 30

Microarray probesets 5

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MGI:1916930

Summaries

All 22

Gene Ontology 1

Phenotypes 3
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

TSS for Lrrc27:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr69696	Chr7:138792890-138792909 (+)	-4 bp
Tssr69697	Chr7:138792919-138792932 (+)	22 bp
Tssr69698	Chr7:138793155-138793220 (+)	284 bp
Tssr69699	Chr7:138793225-138793236 (+)	327 bp
Tssr69700	Chr7:138793296-138793327 (+)	408 bp
Tssr69701	Chr7:138793409-138793428 (+)	515 bp
Tssr69702	Chr7:138794577-138794597 (+)	1,683 bp
Tssr69703	Chr7:138794599-138794625 (+)	1,708 bp
Tssr69704	Chr7:138794626-138794638 (+)	1,728 bp
Tssr69705	Chr7:138794639-138794649 (+)	1,740 bp
Tssr69706	Chr7:138800490-138800535 (+)	7,609 bp
Tssr69707	Chr7:138804892-138804901 (+)	11,993 bp
Tssr69708	Chr7:138815761-138815772 (+)	22,863 bp
Tssr69709	Chr7:138815777-138815794 (+)	22,882 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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