Spatc1l MGI Mouse Gene Detail - MGI:1923823 - spermatogenesis and centriole associated 1 like

Symbol

Spatc1l
Name

spermatogenesis and centriole associated 1 like
Synonyms

1700022B01Rik, 1700027D21Rik

Feature Type

protein coding gene
IDs

MGI:1923823
NCBI Gene: 76573
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr10:76398106-76406035 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.20 cM
Mapping Data

2 experiments

SNPs within 2kb

262 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923823	protein coding gene	Chr10:76394180-76406035 (+)
129S1/SvImJ	ENSMUSG00200041634	protein coding gene	Chr10:73075248-73083178 (+)
A/J	ENSMUSG00195042221	protein coding gene	Chr10:73411869-73419798 (+)
AKR/J	ENSMUSG00220039527	protein coding gene	Chr10:73071578-73079507 (+)
BALB/cJ	ENSMUSG00180052022	protein coding gene	Chr10:73426325-73434254 (+)
C3H/HeJ	ENSMUSG00175042433	protein coding gene	Chr10:73297590-73305519 (+)
C57BL/6NJ	ENSMUSG00215051642	protein coding gene	Chr10:73035238-73043168 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015471	protein coding gene	Chr10:70602590-70608771 (+)
CAST/EiJ	ENSTCUG00005047728	protein coding gene	Chr10:72924737-72932669 (+)
CBA/J	ENSMUSG00210045898	protein coding gene	Chr10:73153793-73161722 (+)
DBA/2J	ENSMUSG00185047144	protein coding gene	Chr10:73496051-73503980 (+)
FVB/NJ	ENSMUSG00205048936	protein coding gene	Chr10:73188726-73196656 (+)
JF1/MsJ	ENSUMUG00000039987	protein coding gene	Chr10:74646292-74654200 (+)
LP/J	ENSMUSG00230043738	protein coding gene	Chr10:75265610-75273539 (+)
NOD/ShiLtJ	ENSMUSG00190045097	protein coding gene	Chr10:73473562-73481491 (+)
NZO/HlLtJ	ENSMUSG00225046152	protein coding gene	Chr10:79562306-79570235 (+)
PWK/PhJ	ENSLUMG00010049737	protein coding gene	Chr10:73037251-73044939 (+)
SPRET/EiJ	ENSMSPG00010040217	protein coding gene	Chr10:74827114-74835129 (+)
WSB/EiJ	ENSIUOG00005044417	protein coding gene	Chr10:73078275-73086224 (+)

Human Ortholog

SPATC1L, spermatogenesis and centriole associated 1 like

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SPATC1L, spermatogenesis and centriole associated 1 like
Synonyms

C21orf56
Links

HGNC:1298

NCBI Gene ID: 84221

UniProt: Q9H0A9
Chr Location

21q22.3; chr21:46161148-46184476 (-) GRCh38

MGI Vertebrate Homology

Spatc1l stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SPATC1L
Gene Tree

Spatc1l

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References

2 with disease annotations

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Phenotype Summary

9 phenotypes from 2 alleles in 2 genetic backgrounds
42 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

3
Targeted

7
Genomic Mutations

5 involving Spatc1l
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male mice homozygous for a null mutation are infertile with acephalic sperm and detached sperm tails. Male mice heterozygous for a null mutation display reduced fertility with similar sperm abnormalities.

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All GO Annotations

17
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

755
Tissues

63
cDNA Data

13
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

44
RefSeq

8
UniProt

2
CCDS

CCDS23949.1, CCDS88029.1

Ensembl

ENSMUSG00000009115 (Evidence)
NCBI Gene

76573

			Length	Strain/Species	Flank
genomic	ENSMUSG00000009115	Ensembl Gene Model \| MGI Sequence Detail	7930	C57BL/6J	± kb
transcript	ENSMUST00000009259	Ensembl \| MGI Sequence Detail	1332	Not Applicable
polypeptide	ENSMUSP00000009259	Ensembl \| MGI Sequence Detail	342	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000060068 speriolin-like protein

(term hierarchy)
InterPro Domains

IPR026715 Speriolin

IPR029384 Speriolin, C-terminal

IPR029385 Speriolin, N-terminal

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All nucleic 15

Genomic 1

cDNA 13

Primer pair 1

Microarray probesets 4

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MGI:1916661, MGI:2652136

Summaries

All 72

Developmental Gene Expression 3

Diseases 2

Gene Ontology 6

Phenotypes 42
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:361105 Tateossian H, et al., DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome. Elife. 2025;

TSS for Spatc1l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94188	Chr10:76398090-76398101 (+)	-10 bp
Tssr94189	Chr10:76398104-76398162 (+)	27 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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