Atg2b MGI Mouse Gene Detail - MGI:1923809

Symbol

Atg2b
Name

autophagy related 2B
Synonyms

2410024A21Rik, C030004M05Rik, C630028L02Rik

Feature Type

protein coding gene
IDs

MGI:1923809
NCBI Gene: 76559
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr12:105582395-105651470 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 55.82 cM
Mapping Data

2 experiments

SNPs within 2kb

1718 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923809	protein coding gene	Chr12:105579798-105651554 (-)
129S1/SvImJ	ENSMUSG00200025268	protein coding gene	Chr12:97352283-97421362 (-)
A/J	ENSMUSG00195019609	protein coding gene	Chr12:99914323-99983400 (-)
AKR/J	ENSMUSG00220038368	protein coding gene	Chr12:97791786-97860861 (-)
BALB/cJ	ENSMUSG00180034370	protein coding gene	Chr12:99102979-99172636 (-)
C3H/HeJ	ENSMUSG00175029723	protein coding gene	Chr12:101731700-101800775 (-)
C57BL/6NJ	ENSMUSG00215039739	protein coding gene	Chr12:98388169-98457247 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018090	protein coding gene	Chr12:100089622-100156353 (-)
CAST/EiJ	ENSTCUG00005018212	protein coding gene	Chr12:97844292-97910967 (-)
CBA/J	ENSMUSG00210013873	protein coding gene	Chr12:98793697-98862774 (-)
DBA/2J	ENSMUSG00185041989	protein coding gene	Chr12:100559359-100628434 (-)
FVB/NJ	ENSMUSG00205013957	protein coding gene	Chr12:97788578-97858139 (-)
JF1/MsJ	ENSUMUG00000013067	protein coding gene	Chr12:105334028-105398404 (-)
LP/J	ENSMUSG00230026001	protein coding gene	Chr12:107617579-107686655 (-)
NOD/ShiLtJ	ENSMUSG00190026222	protein coding gene	Chr12:87352566-87421641 (+)
NZO/HlLtJ	ENSMUSG00225037030	protein coding gene	Chr12:109358072-109427727 (-)
PWK/PhJ	ENSLUMG00010013034	protein coding gene	Chr12:98798321-98863907 (-)
SPRET/EiJ	ENSMSPG00010017316	protein coding gene	Chr12:101096822-101160528 (-)
WSB/EiJ	ENSIUOG00005008553	protein coding gene	Chr12:97796804-97865299 (-)

Human Ortholog

ATG2B, autophagy related 2B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ATG2B, autophagy related 2B
Synonyms

BLTP4B, C14orf103
Links

HGNC:20187

NCBI Gene ID: 55102

UniProt: Q96BY7
Chr Location

14q32.2; chr14:96279195-96363341 (-) GRCh38

MGI Vertebrate Homology

Atg2b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ATG2B
Gene Tree

Atg2b

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

5
Genomic Mutations

1 involving Atg2b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

73 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

28
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

16
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase atg2b

ZFIN atg2b

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All Sequences

57
RefSeq

8
UniProt

3
CCDS

CCDS36550.1

Ensembl

ENSMUSG00000041341 (Evidence)
NCBI Gene

76559

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041341	Ensembl Gene Model \| MGI Sequence Detail	69076	C57BL/6J	± kb
transcript	ENSMUST00000041055	Ensembl \| MGI Sequence Detail	7546	Not Applicable
polypeptide	ENSMUSP00000037441	Ensembl \| MGI Sequence Detail	2075	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000004412 autophagy-related protein 2 homolog B

(term hierarchy)
InterPro Domains

IPR026849 Autophagy-related protein 2

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All nucleic 18

Genomic 2

cDNA 16

Microarray probesets 6

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MGI:1926114, MGI:2144758, MGI:2144850, MGI:2145049, MGI:2441919

Summaries

All 44

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 11
Earliest

J:34253 Gaubatz JW, et al., Mouse satellite DNA is transcribed in senescent cardiac muscle. J Biol Chem. 1990 Oct 15;265(29):17753-8
Latest

J:389864 Murata K, et al., A novel miniTurbo knock-in mouse reveals a protein interaction network of USP46 in the brain. Exp Anim. 2026 Jan 1;75(1):63-72

TSS for Atg2b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr117612	Chr12:105651494-105651569 (-)	-62 bp
Tssr117611	Chr12:105651438-105651490 (-)	6 bp
Tssr117610	Chr12:105651415-105651432 (-)	46 bp
Tssr117609	Chr12:105651389-105651401 (-)	75 bp
Tssr117608	Chr12:105649821-105649825 (-)	1,647 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24