Ccdc6 MGI Mouse Gene Detail - MGI:1923801 - coiled-coil domain containing 6

Symbol

Ccdc6
Name

coiled-coil domain containing 6
Synonyms

2810012H18Rik

Feature Type

protein coding gene
IDs

MGI:1923801
NCBI Gene: 76551
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr10:69932951-70029030 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 36.68 cM
Mapping Data

2 experiments

SNPs within 2kb

637 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923801	protein coding gene	Chr10:69932709-70029030 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017336	protein coding gene	Chr10:70005193-70111895 (+)
A/J	MGP_AJ_G0017313	protein coding gene	Chr10:67633493-67728289 (+)
AKR/J	MGP_AKRJ_G0017274	protein coding gene	Chr10:69470314-69574903 (+)
BALB/cJ	MGP_BALBcJ_G0017273	protein coding gene	Chr10:67837549-67934285 (+)
C3H/HeJ	MGP_C3HHeJ_G0017097	protein coding gene	Chr10:69488503-69584758 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017731	protein coding gene	Chr10:72536619-72647525 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015421	protein coding gene	Chr10:64257431-64352656 (+)
CAST/EiJ	MGP_CASTEiJ_G0016667	protein coding gene	Chr10:69614594-69718647 (+)
CBA/J	MGP_CBAJ_G0017069	protein coding gene	Chr10:75311815-75422512 (+)
DBA/2J	MGP_DBA2J_G0017174	protein coding gene	Chr10:66991182-67087352 (+)
FVB/NJ	MGP_FVBNJ_G0017167	protein coding gene	Chr10:66162158-66259762 (+)
LP/J	MGP_LPJ_G0017247	protein coding gene	Chr10:70454877-70564602 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017195	protein coding gene	Chr10:77443986-77551969 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017770	protein coding gene	Chr10:69420164-69521106 (+)
PWK/PhJ	MGP_PWKPhJ_G0016451	protein coding gene	Chr10:66835256-66933424 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016233	protein coding gene	Chr10:68801291-68896648 (+)
WSB/EiJ	MGP_WSBEiJ_G0016731	protein coding gene	Chr10:69350978-69454318 (+)

Human Ortholog

CCDC6, coiled-coil domain containing 6

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CCDC6, coiled-coil domain containing 6
Synonyms

D10S170, H4, PTC, PTC1, TPC, TST1
Links

HGNC:18782

NCBI Gene ID: 8030

neXtProt AC: NX_Q16204

UniProt: Q16204
Chr Location

10q21.2; chr10:59788747-59906556 (-) GRCh38

MGI Vertebrate Homology

Ccdc6 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CCDC6
Gene Tree

Ccdc6

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

10
Radiation induced

1
Targeted

1
Genomic Mutations

2 involving Ccdc6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mice lacking exon 2 exhibit partial prenatal lethality, thyroid gland hyperplasia, low TSH levels and higher T3 and T4 levels, and decreased embryonic fibroblast proliferation and increased susceptibility to apoptosis.

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All GO Annotations

6
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

5

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ccdc6

ZFIN ccdc6a, ccdc6b

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All Sequences

42
RefSeq

6
UniProt

3
CCDS

CCDS48591.1

Ensembl

ENSMUSG00000048701 (Evidence)
NCBI Gene

76551

			Length	Strain/Species	Flank
genomic	ENSMUSG00000048701	Ensembl Gene Model \| MGI Sequence Detail	96080	C57BL/6J	± kb
transcript	ENSMUST00000147545	Ensembl \| MGI Sequence Detail	5511	Not Applicable
polypeptide	ENSMUSP00000123374	Ensembl \| MGI Sequence Detail	469	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000029346 coiled-coil domain-containing protein 6

(term hierarchy)
InterPro Domains

IPR019152 Protein of unknown function DUF2046

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All nucleic 5

cDNA 5

Microarray probesets 3

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MGI:2143483, MGI:2143514, MGI:2143802

Summaries

All 38

Gene Ontology 4

Phenotypes 14
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:301232 Butterfield NC, et al., Accelerating functional gene discovery in osteoarthritis. Nat Commun. 2021 Jan 20;12(1):467

TSS for Ccdc6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr93987	Chr10:69931181-69931183 (+)	-1,769 bp
Tssr93988	Chr10:69932656-69932689 (+)	-278 bp
Tssr93989	Chr10:69932790-69932795 (+)	-158 bp
Tssr93990	Chr10:69932932-69933041 (+)	36 bp
Tssr93991	Chr10:69933042-69933065 (+)	103 bp
Tssr3241	Chr10:69933067-69933080 (+)	123 bp
Tssr93992	Chr10:69933094-69933131 (+)	162 bp
Tssr93993	Chr10:69945854-69945857 (+)	12,905 bp
Tssr93994	Chr10:69946098-69946126 (+)	13,161 bp
Tssr93995	Chr10:69946130-69946137 (+)	13,183 bp
Tssr93996	Chr10:69947795-69947802 (+)	14,848 bp
Tssr93997	Chr10:70004986-70004999 (+)	72,042 bp
Tssr93998	Chr10:70010843-70010850 (+)	77,896 bp
Tssr93999	Chr10:70017911-70017922 (+)	84,966 bp
Tssr94000	Chr10:70025036-70025064 (+)	92,099 bp
Tssr94001	Chr10:70026256-70026268 (+)	93,311 bp
Tssr94002	Chr10:70027022-70027027 (+)	94,074 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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