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Ly6k Gene Detail
Summary
  • Symbol
    Ly6k
  • Name
    lymphocyte antigen 6 family member K
  • Synonyms
    2410015A16Rik, 3110035B01Rik, mLy-6K
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923736
    NCBI Gene: 76486
  • Member of
    Ly6 cluster
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:74668723-74671817 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 34.28 cM, cytoband E1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    122 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923736
 protein coding gene Chr15:74668723-74671835 (-)
129S1/SvImJ ENSMUSG00200053347
 protein coding gene Chr15:71773085-71776201 (-)
A/J ENSMUSG00195043807
 protein coding gene Chr15:71841754-71844866 (-)
AKR/J ENSMUSG00220050399
 protein coding gene Chr15:71762305-71765417 (-)
BALB/cJ ENSMUSG00180048849
 protein coding gene Chr15:71614206-71617318 (-)
C3H/HeJ ENSMUSG00175046007
 protein coding gene Chr15:71976136-71979248 (-)
C57BL/6NJ ENSMUSG00215047206
 protein coding gene Chr15:71671378-71674490 (-)
CAROLI/EiJ no annotation
CAST/EiJ ENSTCUG00005045629
 protein coding gene Chr15:71273743-71276922 (-)
CBA/J ENSMUSG00210032795
 protein coding gene Chr15:71751491-71754603 (-)
DBA/2J ENSMUSG00185039546
 protein coding gene Chr15:71696899-71700011 (-)
FVB/NJ ENSMUSG00205035894
 protein coding gene Chr15:71442768-71445880 (-)
JF1/MsJ ENSUMUG00000032193
 protein coding gene Chr15:71336142-71339256 (-)
LP/J ENSMUSG00230051496
 protein coding gene Chr15:75060954-75064066 (-)
NOD/ShiLtJ ENSMUSG00190046737
 protein coding gene Chr15:71807785-71810897 (-)
NZO/HlLtJ ENSMUSG00225050663
 protein coding gene Chr15:75334529-75337641 (-)
PWK/PhJ ENSLUMG00010039599
 protein coding gene Chr15:71613911-71617096 (-)
SPRET/EiJ ENSMSPG00010048125
 protein coding gene Chr15:73298453-73301562 (-)
WSB/EiJ ENSIUOG00005045683
 protein coding gene Chr15:71793585-71796700 (-)



Homology
more
  • Human Ortholog
    LY6K, lymphocyte antigen 6 family member K
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LY6K, lymphocyte antigen 6 family member K
  • Synonyms
    CT97, HSJ001348, ly-6K, URLC10
  • Links
    NCBI Gene ID: 54742
    UniProt: Q17RY6

  • Chr Location
    8q24.3; chr8:142700111-142705127 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male infertility associated with impaired sperm migration into the oviduct.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    738
  • Tissues
    61
  • cDNA Data
    4
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 76486 NCBI Gene Model | MGI Sequence Detail 3095 C57BL/6J ±  kb
    transcript NM_029627 RefSeq | MGI Sequence Detail 773 C57BL/6  
    polypeptide Q9CWP4 UniProt | EBI | MGI Sequence Detail 154 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR016054 Ly-6 antigen/uPA receptor-like
      IPR045860 Snake toxin-like superfamily
      IPR052874 Sperm-binding zona pellucida regulatory protein
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 5
      Primer pair 3
      Other 1
      Antibodies 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1920400
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 8
      Phenotypes 31
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory