Kndc1 MGI Mouse Gene Detail - MGI:1923734 - kinase non-catalytic C-lobe domain (KIND) containing 1

Symbol

Kndc1
Name

kinase non-catalytic C-lobe domain (KIND) containing 1
Synonyms

2410012C07Rik, B830014K08Rik, very-kind, VKIND

Feature Type

protein coding gene
IDs

MGI:1923734
NCBI Gene: 76484
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr7:139474612-139521450 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 84.89 cM
Mapping Data

1 experiment

SNPs within 2kb

348 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923734	protein coding gene	Chr7:139474612-139521453 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033154	protein coding gene	Chr7:144969377-145017027 (+)
A/J	MGP_AJ_G0033136	protein coding gene	Chr7:140850991-140897525 (+)
AKR/J	MGP_AKRJ_G0033068	protein coding gene	Chr7:144677578-144730545 (+)
BALB/cJ	MGP_BALBcJ_G0033137	protein coding gene	Chr7:140589787-140636966 (+)
C3H/HeJ	MGP_C3HHeJ_G0032851	protein coding gene	Chr7:144484077-144530761 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033648	protein coding gene	Chr7:150312383-150358792 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030621	protein coding gene	Chr7:141974813-142022028 (+)
CAST/EiJ	MGP_CASTEiJ_G0032181	protein coding gene	Chr7:136784130-136832158 (+)
CBA/J	MGP_CBAJ_G0032824	protein coding gene	Chr7:155381162-155427841 (+)
DBA/2J	MGP_DBA2J_G0032976	protein coding gene	Chr7:138804830-138851771 (+)
FVB/NJ	MGP_FVBNJ_G0032929	protein coding gene	Chr7:138689799-138737963 (+)
LP/J	MGP_LPJ_G0033070	protein coding gene	Chr7:146509614-146561442 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032961	protein coding gene	Chr7:156044798-156092710 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033668	protein coding gene	Chr7:143684727-143732490 (+)
PWK/PhJ	MGP_PWKPhJ_G0031887	protein coding gene	Chr7:131998824-132046255 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031732	protein coding gene	Chr7:130511594-130568619 (+)
WSB/EiJ	MGP_WSBEiJ_G0032292	protein coding gene	Chr7:144580670-144629083 (+)

Human Ortholog

KNDC1, kinase non-catalytic C-lobe domain containing 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KNDC1, kinase non-catalytic C-lobe domain containing 1
Synonyms

bB439H18.3, C10orf23, RASGEF2, Very-KIND, v-KIND
Links

HGNC:29374

NCBI Gene ID: 85442

neXtProt AC: NX_Q76NI1

UniProt: Q76NI1
Chr Location

10q26.3; chr10:133160219-133226412 (+) GRCh38

MGI Vertebrate Homology

Kndc1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: KNDC1
Gene Tree

Kndc1

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Phenotype Summary

11 phenotypes from 1 allele in 1 genetic background
2 images
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

3
Gene trapped

1
Radiation induced

1
Targeted

3
Genomic Mutations

1 involving Kndc1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

93 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are viable and overtly normal but exhibit altered dendritic growth and excitatory synaptic connections in cerebellar granule cells, increased grip strength, and enhanced motor coordination in balance-related tests.

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All GO Annotations

18
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

908
Tissues

51
cDNA Data

34
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA KNDC1

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All Sequences

50
RefSeq

2
UniProt

3

Ensembl

ENSMUSG00000066129 (Evidence)
NCBI Gene

76484

			Length	Strain/Species	Flank
genomic	ENSMUSG00000066129	Ensembl Gene Model \| MGI Sequence Detail	46839	C57BL/6J	± kb
transcript	ENSMUST00000053445	Ensembl \| MGI Sequence Detail	7299	Not Applicable
polypeptide	ENSMUSP00000050586	Ensembl \| MGI Sequence Detail	1742	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000009429 kinase non-catalytic C-lobe domain-containing protein 1

(term hierarchy)
InterPro Domains

IPR029899 Kinase non-catalytic C-lobe domain-containing protein 1

IPR011019 KIND domain

IPR011009 Protein kinase-like domain superfamily

IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamily

IPR023578 Ras guanine nucleotide exchange factor domain superfamily

IPR001895 Ras guanine-nucleotide exchange factors catalytic domain

IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal

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All nucleic 38

cDNA 35

Primer pair 2

Other 1

Microarray probesets 6

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MGI:2444744

Summaries

All 36

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 11
Earliest

J:65007 Cattanach BM, et al., Two imprinted gene mutations: three phenotypes. Hum Mol Genet. 2000 Sep 22;9(15):2263-73
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Kndc1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr69743	Chr7:139474699-139474770 (+)	123 bp
Tssr69744	Chr7:139474773-139474782 (+)	166 bp
Tssr69745	Chr7:139474795-139474800 (+)	186 bp
Tssr69746	Chr7:139474834-139474901 (+)	256 bp
Tssr69747	Chr7:139474903-139474964 (+)	322 bp
Tssr69748	Chr7:139487033-139487037 (+)	12,423 bp
Tssr69749	Chr7:139487314-139487319 (+)	12,705 bp
Tssr69750	Chr7:139494530-139494545 (+)	19,926 bp
Tssr69751	Chr7:139494570-139494581 (+)	19,964 bp
Tssr69752	Chr7:139517964-139518012 (+)	43,376 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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