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Pcolce2 Gene Detail
Summary
  • Symbol
    Pcolce2
  • Name
    procollagen C-endopeptidase enhancer 2
  • Synonyms
    2400001O18Rik, Pcpe2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923727
    NCBI Gene: 76477
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:95519681-95577604 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 50.18 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    776 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923727
 protein coding gene Chr9:95519654-95580149 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035136
 protein coding gene Chr9:96767238-96831292 (+)
A/J MGP_AJ_G0035117
 protein coding gene Chr9:93413992-93476661 (+)
AKR/J MGP_AKRJ_G0035049
 protein coding gene Chr9:95672096-95740419 (+)
BALB/cJ MGP_BALBcJ_G0035110
 protein coding gene Chr9:93101197-93161303 (+)
C3H/HeJ MGP_C3HHeJ_G0034820
 protein coding gene Chr9:96112366-96173623 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035630
 protein coding gene Chr9:99536288-99606057 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0034132
 protein coding gene Chr9:95836335-95899844 (+)
CBA/J MGP_CBAJ_G0034788
 protein coding gene Chr9:102996602-103067963 (+)
DBA/2J MGP_DBA2J_G0034950
 protein coding gene Chr9:92940312-93002026 (+)
FVB/NJ MGP_FVBNJ_G0034898
 protein coding gene Chr9:91789594-91850116 (+)
LP/J MGP_LPJ_G0035029
 protein coding gene Chr9:97035524-97096295 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034937
 protein coding gene Chr9:104996877-105060785 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035652
 protein coding gene Chr9:95899595-95968582 (+)
PWK/PhJ MGP_PWKPhJ_G0033839
 protein coding gene Chr9:93087605-93150444 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033674
 protein coding gene Chr9:95904447-95972300 (+)
WSB/EiJ MGP_WSBEiJ_G0034252
 protein coding gene Chr9:95770084-95834417 (+)



Homology
more
  • Human Ortholog
    PCOLCE2, procollagen C-endopeptidase enhancer 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PCOLCE2, procollagen C-endopeptidase enhancer 2
  • Synonyms
    PCPE2
  • Links
    NCBI Gene ID: 26577
    neXtProt AC: NX_Q9UKZ9
    UniProt: Q9UKZ9

  • Chr Location
    3q23; chr3:142815922-142889206 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    13 phenotype references
Mice homozygous for a knock-out allele are viable, fertile and grossly normal with no detectable abnormalities in thymus or T cell development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    911
  • Tissues
    50
  • cDNA Data
    29
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 76477 NCBI Gene Model | MGI Sequence Detail 57924 C57BL/6J ±  kb
transcript NM_029620 RefSeq | MGI Sequence Detail 1866 C57BL/6  
polypeptide Q8R4W6 UniProt | EBI | MGI Sequence Detail 414 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 34
    Genomic 1
    cDNA 29
    Primer pair 3
    Other 1

    Microarray probesets 4
References
more
  • Summaries
    All 45
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:343299 Vadon-Le Goff S, et al., Identification of PCPE-2 as the endogenous specific inhibitor of human BMP-1/tolloid-like proteinases. Nat Commun. 2023 Dec 4;14(1):8020
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory