Uhrf2 MGI Mouse Gene Detail - MGI:1923718 - ubiquitin-like, containing PHD and RING finger domains 2

Symbol

Uhrf2
Name

ubiquitin-like, containing PHD and RING finger domains 2
Synonyms

2310065A22Rik, D130071B19Rik, Nirf

Feature Type

protein coding gene
IDs

MGI:1923718
NCBI Gene: 109113
Alliance

genome feature page
Transcription Start Sites

9 TSS

Sequence Map

Chr19:30007920-30071126 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 24.73 cM
Mapping Data

2 experiments

SNPs within 2kb

1535 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923718	protein coding gene	Chr19:30007913-30071126 (+)
129S1/SvImJ	ENSMUSG00200020471	protein coding gene	Chr19:26741837-26806341 (+)
A/J	ENSMUSG00195033875	protein coding gene	Chr19:26899311-26963800 (+)
AKR/J	ENSMUSG00220018881	protein coding gene	Chr19:26956116-27020429 (+)
BALB/cJ	ENSMUSG00180013436	protein coding gene	Chr19:27231558-27296032 (+)
C3H/HeJ	ENSMUSG00175023968	protein coding gene	Chr19:26604121-26668579 (+)
C57BL/6NJ	ENSMUSG00215020806	protein coding gene	Chr19:26644601-26709076 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022867	protein coding gene	Chr19:27078422-27141107 (+)
CAST/EiJ	ENSTCUG00005017366	protein coding gene	Chr19:26481356-26546097 (+)
CBA/J	ENSMUSG00210014670	protein coding gene	Chr19:26835055-26899506 (+)
DBA/2J	ENSMUSG00185024507	protein coding gene	Chr19:27221801-27286244 (+)
FVB/NJ	ENSMUSG00205010662	protein coding gene	Chr19:26613707-26678189 (+)
JF1/MsJ	ENSUMUG00000035565	protein coding gene	Chr19:27441522-27505825 (+)
LP/J	ENSMUSG00230028665	protein coding gene	Chr19:28035450-28099936 (+)
NOD/ShiLtJ	ENSMUSG00190021304	protein coding gene	Chr19:26598685-26663161 (+)
NZO/HlLtJ	ENSMUSG00225029283	protein coding gene	Chr19:31791343-31855807 (+)
PWK/PhJ	ENSLUMG00010033906	protein coding gene	Chr19:26818480-26882641 (+)
SPRET/EiJ	ENSMSPG00010031202	protein coding gene	Chr19:26796125-26860607 (+)
WSB/EiJ	ENSIUOG00005027102	protein coding gene	Chr19:26316174-26380695 (+)

Human Ortholog

UHRF2, ubiquitin like with PHD and ring finger domains 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UHRF2, ubiquitin like with PHD and ring finger domains 2
Synonyms

NIRF, RNF107, TDRD23, URF2
Links

HGNC:12557

NCBI Gene ID: 115426

UniProt: Q96PU4
Chr Location

9p24.1; chr9:6413151-6507056 (+) GRCh38

MGI Vertebrate Homology

Uhrf2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: UHRF2
Gene Tree

Uhrf2

less

Phenotype Summary

16 phenotypes from 2 alleles in 2 genetic backgrounds
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Endonuclease-mediated

4
Gene trapped

6
Targeted

9
Genomic Mutations

4 involving Uhrf2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

40 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous KO causes deregulated expression of neuron-related genes, reduced DNA methylation in the brain and impaired contextual conditioning and spatial memory.

less

All GO Annotations

41
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

653
Tissues

53
cDNA Data

19
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase uhrf2

less

All Sequences

68
RefSeq

15
UniProt

3
CCDS

CCDS37955.1

Ensembl

ENSMUSG00000024817 (Evidence)
NCBI Gene

109113

			Length	Strain/Species	Flank
genomic	109113	NCBI Gene Model \| MGI Sequence Detail	63207	C57BL/6J	± kb
transcript	NM_001419330	RefSeq \| MGI Sequence Detail	3536	C57BL/6
polypeptide	Q7TMI3	UniProt \| EBI \| MGI Sequence Detail	803	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000017073 E3 ubiquitin-protein ligase UHRF2

(term hierarchy)
EC

2.3.2.27
InterPro Domains

IPR047407 E3 ubiquitin-protein ligase UHRF2, first Tudor domain

IPR047467 E3 ubiquitin-protein ligase UHRF2, PHD finger

IPR047466 E3 ubiquitin-protein ligase UHRF2, RING finger, HC subclass

IPR047468 E3 ubiquitin-protein ligase UHRF2, ubiquitin-like domain

IPR015947 PUA-like superfamily

IPR003105 SRA-YDG

IPR036987 SRA-YDG superfamily

IPR000626 Ubiquitin-like domain

IPR029071 Ubiquitin-like domain superfamily

IPR045134 UHRF1/2-like

IPR021991 UHRF1, tandem tudor domain

IPR011011 Zinc finger, FYVE/PHD-type

IPR019787 Zinc finger, PHD-finger

IPR001965 Zinc finger, PHD-type

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

IPR017907 Zinc finger, RING-type, conserved site
GlyGen

Q7TMI3 1 site, 1 O-linked glycan (1 site)

less

All nucleic 20

cDNA 19

Primer pair 1

Microarray probesets 3

less

MGI:2147523, MGI:2147720, MGI:2444230

Summaries

All 63

Developmental Gene Expression 7

Gene Ontology 10

Phenotypes 24
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:371055 Bender A, et al., UHRF2 mediates resistance to DNA methylation reprogramming in primordial germ cells. Nat Commun. 2025 Aug 9;16(1):7350

TSS for Uhrf2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr155920	Chr19:30007819-30007830 (+)	-95 bp
Tssr155921	Chr19:30007839-30007928 (+)	-36 bp
Tssr155922	Chr19:30008015-30008034 (+)	105 bp
Tssr155923	Chr19:30008042-30008053 (+)	128 bp
Tssr155924	Chr19:30008063-30008072 (+)	148 bp
Tssr155925	Chr19:30012900-30012935 (+)	4,998 bp
Tssr155926	Chr19:30020159-30020187 (+)	12,253 bp
Tssr155927	Chr19:30034397-30034411 (+)	26,484 bp
Tssr155928	Chr19:30037780-30037784 (+)	29,862 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24