Abcc3 MGI Mouse Gene Detail - MGI:1923658 - ATP-binding cassette, sub-family C member 3

Symbol

Abcc3
Name

ATP-binding cassette, sub-family C member 3
Synonyms

1700019L09Rik, MRP3

Feature Type

protein coding gene
IDs

MGI:1923658
NCBI Gene: 76408
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr11:94234121-94283823 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 58.90 cM
Mapping Data

4 experiments

SNPs within 2kb

436 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923658	protein coding gene	Chr11:94234121-94283843 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018955	protein coding gene	Chr11:96417911-96479689 (-)
A/J	MGP_AJ_G0018923	protein coding gene	Chr11:92571613-92621832 (-)
AKR/J	MGP_AKRJ_G0018893	protein coding gene	Chr11:95449691-95499837 (-)
BALB/cJ	MGP_BALBcJ_G0018896	protein coding gene	Chr11:93021470-93073833 (-)
C3H/HeJ	MGP_C3HHeJ_G0018710	protein coding gene	Chr11:95535321-95588321 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019348	protein coding gene	Chr11:99423296-99487166 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016979	protein coding gene	Chr11:90068623-90117761 (-)
CAST/EiJ	MGP_CASTEiJ_G0018265	protein coding gene	Chr11:96242489-96299309 (-)
CBA/J	MGP_CBAJ_G0018681	protein coding gene	Chr11:103555222-103619021 (-)
DBA/2J	MGP_DBA2J_G0018789	protein coding gene	Chr11:92148692-92200237 (-)
FVB/NJ	MGP_FVBNJ_G0018778	protein coding gene	Chr11:91568790-91620497 (-)
LP/J	MGP_LPJ_G0018859	protein coding gene	Chr11:96968684-97026418 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018805	protein coding gene	Chr11:103586897-103647728 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019388	protein coding gene	Chr11:95674231-95727237 (-)
PWK/PhJ	MGP_PWKPhJ_G0018035	protein coding gene	Chr11:93077649-93131466 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017825	protein coding gene	Chr11:95335278-95389786 (-)
WSB/EiJ	MGP_WSBEiJ_G0018314	protein coding gene	Chr11:95551800-95610313 (-)

Human Ortholog

ABCC3, ATP binding cassette subfamily C member 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ABCC3, ATP binding cassette subfamily C member 3
Synonyms

ABC31, cMOAT2, EST90757, MLP2, MOAT-D, MRP3
Links

HGNC:54

NCBI Gene ID: 8714

neXtProt AC: NX_O15438

UniProt: O15438
Chr Location

17q21.33; chr17:50634777-50692253 (+) GRCh38

MGI Vertebrate Homology

Abcc3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ABCC3
Gene Tree

Abcc3

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Mutations/Alleles

2 with disease annotations

References

2 with disease annotations

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Phenotype Summary

6 phenotypes from 2 alleles in 3 genetic backgrounds
5 phenotypes from multigenic genotypes
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

1
Targeted

9
Transgenic

2
Genomic Mutations

3 involving Abcc3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

70 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene exhibit increased liver bile acid levels after bile duct ligation

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All GO Annotations

36
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

804
Tissues

96
cDNA Data

30
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ABCC3

Xenbase abcc3

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All Sequences

56
RefSeq

7
UniProt

4
CCDS

CCDS25254.1, CCDS88225.1

Ensembl

ENSMUSG00000020865 (Evidence)
NCBI Gene

76408

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020865	Ensembl Gene Model \| MGI Sequence Detail	49703	C57BL/6J	± kb
transcript	ENSMUST00000178136	Ensembl \| MGI Sequence Detail	5005	Not Applicable
polypeptide	ENSMUSP00000136343	Ensembl \| MGI Sequence Detail	1523	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000003559 ATP-binding cassette sub-family C member 3

(term hierarchy)
EC

7.6.2.-, 7.6.2.2, 7.6.2.3
InterPro Domains

IPR003593 AAA+ ATPase domain

IPR003439 ABC transporter-like, ATP-binding domain

IPR017871 ABC transporter-like, conserved site

IPR011527 ABC transporter type 1, transmembrane domain

IPR036640 ABC transporter type 1, transmembrane domain superfamily

IPR005292 Multi drug resistance-associated protein

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 32

cDNA 30

Primer pair 2

Microarray probesets 3

Summaries

All 66

Developmental Gene Expression 5

Diseases 2

Gene Ontology 12

Phenotypes 22
Earliest

J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
Latest

J:304359 Zhang X, et al., The Metabolic Reprogramming of Frem2 Mutant Mice Embryos in Cryptophthalmos Development. Front Cell Dev Biol. 2020;8:625492

TSS for Abcc3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr110171	Chr11:94283743-94283809 (-)	47 bp
Tssr110170	Chr11:94265938-94265961 (-)	17,873 bp
Tssr110169	Chr11:94262566-94262578 (-)	21,251 bp
Tssr110168	Chr11:94256260-94256274 (-)	27,556 bp
Tssr110167	Chr11:94256245-94256252 (-)	27,574 bp
Tssr110166	Chr11:94250974-94250976 (-)	32,848 bp
Tssr110165	Chr11:94249694-94249703 (-)	34,124 bp
Tssr110164	Chr11:94249672-94249682 (-)	34,146 bp
Tssr110163	Chr11:94242970-94242979 (-)	40,848 bp
Tssr110162	Chr11:94242928-94242955 (-)	40,881 bp
Tssr110161	Chr11:94242172-94242176 (-)	41,649 bp
Tssr110160	Chr11:94236958-94236983 (-)	46,852 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23