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Txndc11 Gene Detail
Summary
  • Symbol
    Txndc11
  • Name
    thioredoxin domain containing 11
  • Synonyms
    2810408E11Rik, EF-hand binding protein 1, EFP1, Txdc11
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923620
    NCBI Gene: 106200
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:10892775-10952514 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 6.33 cM, cytoband B1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1374 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923620
 protein coding gene Chr16:10892775-10952541 (-)
129S1/SvImJ ENSMUSG00200011415
 protein coding gene Chr16:7898337-7958099 (-)
A/J ENSMUSG00195011246
 protein coding gene Chr16:7436423-7496161 (-)
AKR/J ENSMUSG00220016792
 protein coding gene Chr16:7725230-7784972 (-)
BALB/cJ ENSMUSG00180007846
 protein coding gene Chr16:7675629-7735372 (-)
C3H/HeJ ENSMUSG00175026737
 protein coding gene Chr16:7866994-7926213 (-)
C57BL/6NJ ENSMUSG00215016399
 protein coding gene Chr16:7542312-7602052 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020455
 protein coding gene Chr16:7646461-7706140 (-)
CAST/EiJ ENSTCUG00005028981
 protein coding gene Chr16:7800557-7859110 (-)
CBA/J ENSMUSG00210011505
 protein coding gene Chr16:7884157-7943373 (-)
DBA/2J ENSMUSG00185009271
 protein coding gene Chr16:7829499-7888719 (-)
FVB/NJ ENSMUSG00205010074
 protein coding gene Chr16:7745652-7805403 (-)
JF1/MsJ ENSUMUG00000026146
 protein coding gene Chr16:7946971-8005760 (-)
LP/J ENSMUSG00230042953
 protein coding gene Chr16:10394109-10453866 (-)
NOD/ShiLtJ ENSMUSG00190023370
 protein coding gene Chr16:7927835-7987576 (-)
NZO/HlLtJ ENSMUSG00225030961
 protein coding gene Chr16:13612134-13671870 (-)
PWK/PhJ ENSLUMG00010017080
 protein coding gene Chr16:7799467-7858097 (-)
SPRET/EiJ ENSMSPG00010015599
 protein coding gene Chr16:7771447-7828680 (-)
WSB/EiJ ENSIUOG00005015153
 protein coding gene Chr16:7893351-7952654 (-)



Homology
more
  • Human Ortholog
    TXNDC11, thioredoxin domain containing 11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TXNDC11, thioredoxin domain containing 11
  • Synonyms
    EFP1
  • Links
    NCBI Gene ID: 51061
    UniProt: Q6PKC3

  • Chr Location
    16p13.13; chr16:11679079-11742907 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    59
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022498 Ensembl Gene Model | MGI Sequence Detail 59740 C57BL/6J ±  kb
    transcript ENSMUST00000038424 Ensembl | MGI Sequence Detail 3095 Not Applicable  
    polypeptide ENSMUSP00000041113 Ensembl | MGI Sequence Detail 948 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000016857 thioredoxin domain-containing protein 11
      (term hierarchy)
    • InterPro Domains
      IPR013766 Thioredoxin domain
      IPR052792 Thioredoxin domain-containing protein 11
      IPR036249 Thioredoxin-like superfamily
      IPR058777 TXNDC11, thioredoxin-like domain
    • GlyGen
      Q8K2W3 5 sites, 2 N-linked glycans (4 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 59
      cDNA 59

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2146427
    References
    more
    • Summaries
      All 36
      Gene Ontology 3
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory