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Exosc4 Gene Detail
Summary
  • Symbol
    Exosc4
  • Name
    exosome component 4
  • Synonyms
    1110039I09Rik, 1500001N04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923576
    NCBI Gene: 109075
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:76211597-76214870 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 35.72 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    26 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923576
 protein coding gene Chr15:76211597-76214877 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021983
 protein coding gene Chr15:76396621-76399895 (+)
A/J MGP_AJ_G0021941
 protein coding gene Chr15:73615435-73618718 (+)
AKR/J MGP_AKRJ_G0021924
 protein coding gene Chr15:75612944-75616216 (+)
BALB/cJ MGP_BALBcJ_G0021950
 protein coding gene Chr15:73641545-73644820 (+)
C3H/HeJ MGP_C3HHeJ_G0021722
 protein coding gene Chr15:75657595-75660868 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022390
 protein coding gene Chr15:79250889-79254197 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019919
 protein coding gene Chr15:70276704-70280211 (+)
CAST/EiJ MGP_CASTEiJ_G0021241
 protein coding gene Chr15:76455600-76458878 (+)
CBA/J MGP_CBAJ_G0021689
 protein coding gene Chr15:81749712-81752983 (+)
DBA/2J MGP_DBA2J_G0021814
 protein coding gene Chr15:73151534-73154804 (+)
FVB/NJ MGP_FVBNJ_G0021795
 protein coding gene Chr15:72199680-72203957 (+)
LP/J MGP_LPJ_G0021885
 protein coding gene Chr15:76487047-76492450 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021819
 protein coding gene Chr15:87087925-87091191 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022410
 protein coding gene Chr15:75857130-75860405 (+)
PWK/PhJ MGP_PWKPhJ_G0020982
 protein coding gene Chr15:73301175-73304571 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020822
 protein coding gene Chr15:75578423-75581680 (+)
WSB/EiJ MGP_WSBEiJ_G0021293
 protein coding gene Chr15:75954404-75957693 (+)



Homology
more
  • Human Ortholog
    EXOSC4, exosome component 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EXOSC4, exosome component 4
  • Synonyms
    hRrp41p, p12A, RRP41, RRP41A, Rrp41p, SKI6, Ski6p
  • Links
    NCBI Gene ID: 54512
    neXtProt AC: NX_Q9NPD3
    UniProt: Q9NPD3

  • Chr Location
    8q24.3; chr8:144064056-144080648 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    721
  • Tissues
    15
  • cDNA Data
    81
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 109075 NCBI Gene Model | MGI Sequence Detail 3274 C57BL/6J ±  kb
transcript NM_175399 RefSeq | MGI Sequence Detail 1789 C57BL/6  
polypeptide Q921I9 UniProt | EBI | MGI Sequence Detail 245 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000007261 exosome complex component RRP41
    (term hierarchy)
  • InterPro Domains
    IPR036345 Exoribonuclease, PH domain 2 superfamily
    IPR001247 Exoribonuclease, phosphorolytic domain 1
    IPR015847 Exoribonuclease, phosphorolytic domain 2
    IPR027408 PNPase/RNase PH domain superfamily
    IPR020568 Ribosomal protein uS5 domain 2-type superfamily
Molecular
Reagents
less
  • All nucleic 83
    cDNA 82
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1916201
References
more
  • Summaries
    All 55
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 9
    Phenotypes 28
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:343201 Srinivasan S, et al., Exosome complex components 1 and 2 are vital for early mammalian development. Gene Expr Patterns. 2023 Nov 7;51:119346
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory