Ndfip2 MGI Mouse Gene Detail - MGI:1923523 - Nedd4 family interacting protein 2

Symbol

Ndfip2
Name

Nedd4 family interacting protein 2
Synonyms

0710001O20Rik, 9130207N19Rik, N4wbp5a

Feature Type

protein coding gene
IDs

MGI:1923523
NCBI Gene: 76273
Alliance

genome feature page
Transcription Start Sites

8 TSS

Sequence Map

Chr14:105496008-105546732 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 55.64 cM
Mapping Data

1 experiment

SNPs within 2kb

1441 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923523	protein coding gene	Chr14:105495975-105546732 (+)
129S1/SvImJ	ENSMUSG00200018038	protein coding gene	Chr14:94097089-94147833 (+)
A/J	ENSMUSG00195004126	protein coding gene	Chr14:94181115-94231866 (+)
AKR/J	ENSMUSG00220001099	protein coding gene	Chr14:93608511-93659273 (+)
BALB/cJ	ENSMUSG00180010171	protein coding gene	Chr14:93664699-93715433 (+)
C3H/HeJ	ENSMUSG00175013711	protein coding gene	Chr14:95555932-95606693 (+)
C57BL/6NJ	ENSMUSG00215006358	protein coding gene	Chr14:93750312-93800834 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019581	protein coding gene	Chr14:95232934-95280726 (+)
CAST/EiJ	ENSTCUG00005002737	protein coding gene	Chr14:95130353-95179588 (+)
CBA/J	ENSMUSG00210013963	protein coding gene	Chr14:94243391-94294140 (+)
DBA/2J	ENSMUSG00185010865	protein coding gene	Chr14:99397718-99448722 (+)
FVB/NJ	ENSMUSG00205008164	protein coding gene	Chr14:93356313-93407388 (+)
JF1/MsJ	ENSUMUG00000011962	protein coding gene	Chr14:110426826-110478374 (+)
LP/J	ENSMUSG00230003200	protein coding gene	Chr14:111274704-111349215 (+)
NOD/ShiLtJ	ENSMUSG00190001619	protein coding gene	Chr14:94033991-94084728 (+)
NZO/HlLtJ	ENSMUSG00225025026	protein coding gene	Chr14:101682849-101733352 (+)
PWK/PhJ	ENSLUMG00010001109	protein coding gene	Chr14:93294189-93345200 (+)
SPRET/EiJ	ENSMSPG00010009053	protein coding gene	Chr14:97284479-97331730 (+)
WSB/EiJ	ENSIUOG00005006276	protein coding gene	Chr14:93231686-93282184 (+)

Human Ortholog

NDFIP2, Nedd4 family interacting protein 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NDFIP2, Nedd4 family interacting protein 2
Synonyms

N4WBP5A
Links

HGNC:18537

NCBI Gene ID: 54602

UniProt: Q9NV92
Chr Location

13q31.1; chr13:79481155-79556077 (+) GRCh38

MGI Vertebrate Homology

Ndfip2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NDFIP2
Gene Tree

Ndfip2

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Phenotype Summary

16 phenotypes from 2 alleles in 2 genetic backgrounds
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

3
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Ndfip2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are viable and exhibit normal hematological parameters. However, when fed a low iron diet, female homozygotes display a decrease in liver iron content and are able to maintain normal serum iron levels and transferrin saturation, unlike wild-type females.

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All GO Annotations

25
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

767
Tissues

50
cDNA Data

14
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA NDFIP2

Xenbase ndfip2

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All Sequences

68
RefSeq

5
UniProt

8
CCDS

CCDS49560.2

Ensembl

ENSMUSG00000053253 (Evidence)
NCBI Gene

76273

			Length	Strain/Species	Flank
genomic	ENSMUSG00000053253	Ensembl Gene Model \| MGI Sequence Detail	50725	C57BL/6J	± kb
transcript	ENSMUST00000181969	Ensembl \| MGI Sequence Detail	2532	Not Applicable
polypeptide	ENSMUSP00000137875	Ensembl \| MGI Sequence Detail	338	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000011054 NEDD4 family-interacting protein 2

(term hierarchy)
InterPro Domains

IPR019325 NEDD4/Bsd2

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All nucleic 19

Genomic 1

cDNA 16

Primer pair 1

Other 1

Microarray probesets 3

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MGI:1924402

Summaries

All 51

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 20
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:386373 Canada-Garcia D, et al., Ndfip2 in TrkA-expressing sensory neurons regulates noxious mechanosensation through control of TrkA signaling and protein levels. Cell Death Dis. 2026 Mar 31;17(1)

TSS for Ndfip2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr127080	Chr14:105496047-105496064 (+)	48 bp
Tssr127081	Chr14:105496121-105496132 (+)	119 bp
Tssr127082	Chr14:105496147-105496193 (+)	162 bp
Tssr127083	Chr14:105496199-105496216 (+)	200 bp
Tssr127084	Chr14:105496233-105496251 (+)	234 bp
Tssr127085	Chr14:105496256-105496269 (+)	255 bp
Tssr127086	Chr14:105496270-105496280 (+)	267 bp
Tssr127087	Chr14:105496284-105496325 (+)	297 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24