Coa5 MGI Mouse Gene Detail - MGI:1923428 - cytochrome C oxidase assembly factor 5

Symbol

Coa5
Name

cytochrome C oxidase assembly factor 5
Synonyms

1700001A24Rik, 6330578E17Rik, Pet191

Feature Type

protein coding gene
IDs

MGI:1923428
NCBI Gene: 76178
Alliance

genome feature page
Transcription Start Sites

6 TSS

Sequence Map

Chr1:37456166-37469184 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 15.46 cM
Mapping Data

2 experiments

SNPs within 2kb

400 from dbSNP Build 142
Strain Annotations

27

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923428	protein coding gene	Chr1:37456165-37469184 (-)
129S1/SvImJ	ENSMUSG00200002874	protein coding gene	Chr1:35046237-35048085 (-)
129S1/SvImJ	ENSMUSG00200002884	protein coding gene	Chr1:35047713-35059331 (-)
A/J	ENSMUSG00195042730	protein coding gene	Chr1:34693506-34706640 (-)
AKR/J	ENSMUSG00220008010	protein coding gene	Chr1:34709077-34720695 (-)
AKR/J	ENSMUSG00220008001	protein coding gene	Chr1:34707601-34709449 (-)
BALB/cJ	ENSMUSG00180011169	protein coding gene	Chr1:34792982-34804600 (-)
BALB/cJ	ENSMUSG00180011162	protein coding gene	Chr1:34791506-34793354 (-)
C3H/HeJ	ENSMUSG00175001347	protein coding gene	Chr1:34699004-34710716 (-)
C57BL/6NJ	ENSMUSG00215017754	protein coding gene	Chr1:34769944-34781562 (-)
C57BL/6NJ	ENSMUSG00215017696	protein coding gene	Chr1:34768468-34770316 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014050	protein coding gene	Chr1:32061820-32074835 (-)
CAST/EiJ	ENSTCUG00005002813	protein coding gene	Chr1:34842409-34855484 (-)
CBA/J	ENSMUSG00210005355	protein coding gene	Chr1:34520145-34521993 (-)
CBA/J	ENSMUSG00210005368	protein coding gene	Chr1:34521621-34533239 (-)
DBA/2J	ENSMUSG00185010399	protein coding gene	Chr1:35620945-35634018 (-)
FVB/NJ	ENSMUSG00205017605	protein coding gene	Chr1:34723447-34725295 (-)
FVB/NJ	ENSMUSG00205017638	protein coding gene	Chr1:34724923-34736541 (-)
JF1/MsJ	ENSUMUG00000008299	protein coding gene	Chr1:34815925-34829115 (-)
LP/J	ENSMUSG00230024517	protein coding gene	Chr1:35666882-35668730 (-)
LP/J	ENSMUSG00230024522	protein coding gene	Chr1:35668358-35679976 (-)
NOD/ShiLtJ	ENSMUSG00190023267	protein coding gene	Chr1:34729717-34741429 (-)
NZO/HlLtJ	ENSMUSG00225014090	protein coding gene	Chr1:38909646-38921264 (-)
NZO/HlLtJ	ENSMUSG00225014085	protein coding gene	Chr1:38908170-38910018 (-)
PWK/PhJ	ENSLUMG00010030052	protein coding gene	Chr1:34362895-34374606 (-)
SPRET/EiJ	ENSMSPG00010023026	protein coding gene	Chr1:35815934-35829482 (-)
WSB/EiJ	ENSIUOG00005032897	protein coding gene	Chr1:34652803-34665817 (-)

Human Ortholog

COA5, cytochrome c oxidase assembly factor 5

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

COA5, cytochrome c oxidase assembly factor 5
Synonyms

6330578E17Rik, C2orf64, CEMCOX3, MC4DN9, Pet191
Links

HGNC:33848

NCBI Gene ID: 493753

UniProt: Q86WW8
Chr Location

chr2:98598242-98608515 (-) GRCh38

MGI Vertebrate Homology

Coa5 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: COA5
Gene Tree

Coa5

Diseases

1 with human COA5 associations

				Human Disease	Mouse Models
				mitochondrial complex IV deficiency nuclear type 9 IDs mitochondrial complex IV deficiency nuclear type 9 DOID:0080359 OMIM:616500 UMLS_CUI:C4225154

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Gene trapped

3
Targeted

5
Genomic Mutations

1 involving Coa5
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

7 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

12
GO References

7

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

688
Tissues

18
cDNA Data

121
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase coa5

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All Sequences

60
RefSeq

2
UniProt

2
CCDS

CCDS35541.1

Ensembl

ENSMUSG00000026112 (Evidence)
NCBI Gene

76178

			Length	Strain/Species	Flank
genomic	76178	NCBI Gene Model \| MGI Sequence Detail	13019	C57BL/6J	± kb
transcript	NM_198006	RefSeq \| MGI Sequence Detail	3862	C57BL/6
polypeptide	Q99M07	UniProt \| EBI \| MGI Sequence Detail	74	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000032383 cytochrome c oxidase assembly factor 5

(term hierarchy)
InterPro Domains

IPR018793 Cytochrome c oxidase assembly protein PET191

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All nucleic 121

cDNA 121

Microarray probesets 5

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MGI:1922068

Summaries

All 42

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 13
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Coa5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr11301	Chr1:37469152-37469161 (-)	27 bp
Tssr11300	Chr1:37469097-37469138 (-)	66 bp
Tssr11299	Chr1:37469091-37469096 (-)	90 bp
Tssr11298	Chr1:37469070-37469081 (-)	108 bp
Tssr11297	Chr1:37457977-37457992 (-)	11,199 bp
Tssr11296	Chr1:37457890-37457919 (-)	11,279 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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