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Cavin3 Gene Detail
Summary
  • Symbol
    Cavin3
  • Name
    caveolae associated 3
  • Synonyms
    3110015B12Rik, 6330514M23Rik, cavin 3, Prkcdbp
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923422
    NCBI Gene: 109042
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:105129823-105131404 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 55.87 cM, cytoband F1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    145 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923422
 protein coding gene Chr7:105129290-105131507 (-)
129S1/SvImJ ENSMUSG00200033584
 protein coding gene Chr7:91888422-91890639 (-)
A/J ENSMUSG00195053158
 protein coding gene Chr7:96390942-96393159 (-)
AKR/J ENSMUSG00220044956
 protein coding gene Chr7:89768241-89770458 (-)
BALB/cJ ENSMUSG00180036803
 protein coding gene Chr7:93070497-93072714 (-)
C3H/HeJ ENSMUSG00175048813
 protein coding gene Chr7:93713585-93715802 (-)
C57BL/6NJ ENSMUSG00215049401
 protein coding gene Chr7:92983024-92985241 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030228
 protein coding gene Chr7:107867921-107869523 (-)
CAST/EiJ ENSTCUG00005053030
 protein coding gene Chr7:96390911-96393120 (-)
CBA/J ENSMUSG00210037900
 protein coding gene Chr7:93539079-93541296 (-)
DBA/2J ENSMUSG00185056595
 protein coding gene Chr7:97891492-97893709 (-)
FVB/NJ ENSMUSG00205038403
 protein coding gene Chr7:93524692-93526908 (-)
JF1/MsJ ENSUMUG00000022022
 protein coding gene Chr7:102948032-102950269 (-)
LP/J ENSMUSG00230047238
 protein coding gene Chr7:103993147-103995364 (-)
NOD/ShiLtJ ENSMUSG00190044502
 protein coding gene Chr7:93868520-93870728 (-)
NZO/HlLtJ ENSMUSG00225017444
 protein coding gene Chr7:102185241-102187458 (-)
PWK/PhJ ENSLUMG00010032729
 protein coding gene Chr7:92069681-92071913 (-)
SPRET/EiJ ENSMSPG00010029350
 protein coding gene Chr7:93293716-93295926 (-)
WSB/EiJ ENSIUOG00005044798
 protein coding gene Chr7:94113767-94116001 (-)



Homology
more
  • Human Ortholog
    CAVIN3, caveolae associated protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CAVIN3, caveolae associated protein 3
  • Synonyms
    cavin-3, HSRBC, PRKCDBP, SRBC
  • Links
    NCBI Gene ID: 112464
    UniProt: Q969G5

  • Chr Location
    11p15.4; chr11:6318946-6320546 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased body weight, severe lipodystrophy, hepatic steatosis, increased fermentative glycolysis in lung tissue, and premature death as a result of cachexia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    674
  • Tissues
    29
  • cDNA Data
    63
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 109042 NCBI Gene Model | MGI Sequence Detail 1582 C57BL/6J ±  kb
    transcript NM_028444 RefSeq | MGI Sequence Detail 1026 Not Specified  
    polypeptide Q91VJ2 UniProt | EBI | MGI Sequence Detail 260 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 63
      cDNA 63

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1920378, MGI:5896596
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 3
      Gene Ontology 10
      Phenotypes 21
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory