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Gpsm2 Gene Detail
Summary
  • Symbol
    Gpsm2
  • Name
    G-protein signalling modulator 2 (AGS3-like, C. elegans)
  • Synonyms
    6230410J09Rik, LGN, Pins
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923373
    NCBI Gene: 76123
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:108585954-108629625 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 47.53 cM, cytoband F3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    247 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923373
 protein coding gene Chr3:108585954-108629637 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027784
 protein coding gene Chr3:110252599-110295073 (-)
A/J MGP_AJ_G0027744
 protein coding gene Chr3:106751681-106795331 (-)
AKR/J MGP_AKRJ_G0027709
 protein coding gene Chr3:109343058-109391693 (-)
BALB/cJ MGP_BALBcJ_G0027756
 protein coding gene Chr3:106448456-106494356 (-)
C3H/HeJ MGP_C3HHeJ_G0027486
 protein coding gene Chr3:109701849-109748455 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028200
 protein coding gene Chr3:114344511-114388467 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025538
 protein coding gene Chr3:102880246-102921728 (-)
CAST/EiJ MGP_CASTEiJ_G0026942
 protein coding gene Chr3:109091720-109134536 (-)
CBA/J MGP_CBAJ_G0027461
 protein coding gene Chr3:118259437-118302737 (-)
DBA/2J MGP_DBA2J_G0027603
 protein coding gene Chr3:105923308-105965857 (-)
FVB/NJ MGP_FVBNJ_G0027571
 protein coding gene Chr3:103813849-103855452 (-)
LP/J MGP_LPJ_G0027710
 protein coding gene Chr3:111664131-111708344 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027601
 protein coding gene Chr3:124296328-124340642 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028255
 protein coding gene Chr3:108946402-108987813 (-)
PWK/PhJ MGP_PWKPhJ_G0026668
 protein coding gene Chr3:105678774-105720797 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026488
 protein coding gene Chr3:107090852-107137651 (-)
WSB/EiJ MGP_WSBEiJ_G0027022
 protein coding gene Chr3:109481876-109527616 (-)



Homology
more
  • Human Ortholog
    GPSM2, G protein signaling modulator 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPSM2, G protein signaling modulator 2
  • Synonyms
    CMCS, DFNB82, LGN, PINS
  • Links
    NCBI Gene ID: 29899
    neXtProt AC: NX_P81274
    UniProt: P81274

  • Chr Location
    1p13.3; chr1:108875350-108934545 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GPSM2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 3 alleles in 3 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted disruption of this gene randomizes the spindle orientation of normally planar neuroepithelial divisions. The ensuing loss of the apical membrane from daughter cells frequently converts them into abnormally localized progenitors with no apparent effect on neuronal production.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    946
  • Tissues
    104
  • cDNA Data
    9
  • Literature Summary
    33
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027883 Ensembl Gene Model | MGI Sequence Detail 43672 C57BL/6J ±  kb
    transcript ENSMUST00000029482 Ensembl | MGI Sequence Detail 3498 Not Applicable  
    polypeptide ENSMUSP00000029482 Ensembl | MGI Sequence Detail 679 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 9
      Primer pair 2
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 93
      Developmental Gene Expression 33
      Diseases 1
      Gene Ontology 12
      Phenotypes 30
    • Earliest
      J:54235 Luo Y, et al., Interaction of heterotrimeric G protein Galphao with Purkinje cell protein-2. Evidence for a novel nucleotide exchange factor. J Biol Chem. 1999 Apr 16;274(16):10685-8
    • Latest
      J:346587 Viala S, et al., LGN loss randomizes spindle orientation and accelerates tumorigenesis in PTEN-deficient epidermis. Mol Biol Cell. 2024 Feb 1;35(2):br5
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory