Ccdc125 MGI Mouse Gene Detail - MGI:1923291 - coiled-coil domain containing 125

Symbol

Ccdc125
Name

coiled-coil domain containing 125
Synonyms

5830436D01Rik

Feature Type

protein coding gene
IDs

MGI:1923291
NCBI Gene: 76041
Alliance

genome feature page
Transcription Start Sites

4 TSS

Sequence Map

Chr13:100806225-100833748 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 53.23 cM
Mapping Data

2 experiments

SNPs within 2kb

1073 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923291	protein coding gene	Chr13:100805442-100833748 (+)
129S1/SvImJ	ENSMUSG00200008565	protein coding gene	Chr13:95297205-95324729 (+)
A/J	ENSMUSG00195028413	protein coding gene	Chr13:95845000-95872581 (+)
AKR/J	ENSMUSG00220024932	protein coding gene	Chr13:94266288-94293814 (+)
BALB/cJ	ENSMUSG00180032959	protein coding gene	Chr13:96383446-96410971 (+)
C3H/HeJ	ENSMUSG00175015330	protein coding gene	Chr13:96481918-96509441 (+)
C57BL/6NJ	ENSMUSG00215021919	protein coding gene	Chr13:96458602-96486126 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018846	protein coding gene	Chr13:94432542-94461811 (+)
CAST/EiJ	ENSTCUG00005010426	protein coding gene	Chr13:95619026-95647836 (+)
CBA/J	ENSMUSG00210011504	protein coding gene	Chr13:95805562-95833085 (+)
DBA/2J	ENSMUSG00185016600	protein coding gene	Chr13:99549571-99577094 (+)
FVB/NJ	ENSMUSG00205032121	protein coding gene	Chr13:95177233-95204765 (+)
JF1/MsJ	ENSUMUG00000019931	protein coding gene	Chr13:99174646-99202839 (+)
LP/J	ENSMUSG00230032860	protein coding gene	Chr13:109710433-109737958 (+)
NOD/ShiLtJ	ENSMUSG00190036014	protein coding gene	Chr13:96137244-96164770 (+)
NZO/HlLtJ	ENSMUSG00225036875	protein coding gene	Chr13:102064129-102091652 (+)
PWK/PhJ	ENSLUMG00010022854	protein coding gene	Chr13:95207602-95235146 (+)
SPRET/EiJ	ENSMSPG00010008255	protein coding gene	Chr13:96561975-96589517 (+)
WSB/EiJ	ENSIUOG00005033145	protein coding gene	Chr13:95218977-95247388 (+)

Human Ortholog

CCDC125, coiled-coil domain containing 125

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CCDC125, coiled-coil domain containing 125
Synonyms

KENAE
Links

HGNC:28924

NCBI Gene ID: 202243

UniProt: Q86Z20
Chr Location

5q13.2; chr5:69273039-69332809 (-) GRCh38

MGI Vertebrate Homology

Ccdc125 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CCDC125
Gene Tree

Ccdc125

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References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

2
Gene trapped

5
Targeted

2
Transgenic

1
Genomic Mutations

1 involving Ccdc125
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available

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All GO Annotations

14
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

15

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ccdc125

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All Sequences

45
RefSeq

14
UniProt

2
CCDS

CCDS26736.1, CCDS49346.1

Ensembl

ENSMUSG00000048924 (Evidence)
NCBI Gene

76041

			Length	Strain/Species	Flank
genomic	ENSMUSG00000048924	Ensembl Gene Model \| MGI Sequence Detail	27524	C57BL/6J	± kb
transcript	ENSMUST00000057325	Ensembl \| MGI Sequence Detail	2413	Not Applicable
polypeptide	ENSMUSP00000058484	Ensembl \| MGI Sequence Detail	500	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000029314 coiled-coil domain-containing protein 125

(term hierarchy)
InterPro Domains

IPR063434 CCDC125 2, coiled coil domain

IPR034608 Coiled-coil domain-containing protein 125

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All nucleic 15

cDNA 15

Microarray probesets 2

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MGI:2145321

Summaries

All 38

Diseases 1

Gene Ontology 5

Phenotypes 15
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:358278 Yang Y, et al., Erythrocytic alpha-Synuclein and the Gut Microbiome: Kindling of the Gut-Brain Axis in Parkinson's Disease. Mov Disord. 2024 Jan;39(1):40-52

TSS for Ccdc125:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr120851	Chr13:100806206-100806262 (+)	9 bp
Tssr120852	Chr13:100812611-100812644 (+)	6,403 bp
Tssr120853	Chr13:100812648-100812658 (+)	6,428 bp
Tssr120854	Chr13:100822703-100822707 (+)	16,480 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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