Hdnr Gene Detail

Summary

• Symbol
  Hdnr
• Name
  Hand2 downstream lncRNA
• Synonyms
  5033428I22Rik, Handlr, handsdown, Hdn

• Feature Type
  lncRNA gene
• IDs
  MGI:1923246
  NCBI Gene: 75996
• Alliance
  genome feature page
• Transcription Start Sites
  3 TSS

Location &
Maps

• Sequence Map
  Chr8:57785470-57807615 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 8, 29.80 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  606 from dbSNP Build 142
• Strain Annotations
  19

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923246	lncRNA gene	Chr8:57784724-57868145 (+)
129S1/SvImJ	ENSMUSG00200007959	lncRNA gene	Chr8:52573034-52618461 (+)
A/J	ENSMUSG00195012435	lncRNA gene	Chr8:52974564-53020017 (+)
AKR/J	ENSMUSG00220006000	lncRNA gene	Chr8:52796568-52843749 (+)
BALB/cJ	ENSMUSG00180014450	lncRNA gene	Chr8:52626765-52673948 (+)
C3H/HeJ	ENSMUSG00175007829	lncRNA gene	Chr8:52804018-52851192 (+)
C57BL/6NJ	ENSMUSG00215010384	lncRNA gene	Chr8:52590411-52637636 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0006671	lincRNA gene	Chr8:50198221-50206810 (+)
CAST/EiJ	ENSTCUG00005006718	lncRNA gene	Chr8:52544164-52592032 (+)
CBA/J	ENSMUSG00210009305	lncRNA gene	Chr8:52648735-52694166 (+)
DBA/2J	ENSMUSG00185008066	lncRNA gene	Chr8:58786059-58833244 (+)
FVB/NJ	ENSMUSG00205012472	lncRNA gene	Chr8:52040982-52088169 (+)
JF1/MsJ	ENSUMUG00000013819	lncRNA gene	Chr8:61113756-61167327 (+)
LP/J	ENSMUSG00230006927	lncRNA gene	Chr8:62445113-62492269 (+)
NOD/ShiLtJ	ENSMUSG00190010297	lncRNA gene	Chr8:52569981-52615403 (+)
NZO/HlLtJ	ENSMUSG00225031066	lncRNA gene	Chr8:65872036-65917463 (+)
PWK/PhJ	ENSLUMG00010013415	lncRNA gene	Chr8:52484329-52538234 (+)
SPRET/EiJ	ENSMSPG00010015152	lncRNA gene	Chr8:53563735-53610832 (+)
WSB/EiJ	ENSIUOG00005017311	lncRNA gene	Chr8:53492574-53539903 (+)

Homology

• Gene Tree
  Hdnr
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  3 phenotypes from 1 allele in 1 genetic background
  4 phenotype references
  

• All Mutations and Alleles
  7
• Chemically induced (other)
  1
• Endonuclease-mediated
  6
• Genomic Mutations
  1 involving Hdnr
• Find Mice (IMSR)
  0 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype
• Recombinase Activity
  Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a null allele exhibit decreased heart left ventricle weight and increased cardiac muscle contractility but exhibit reduced lung hypertrophy following trans-aortic constriction.

Expression

• Assay Results
  634
• Tissues
  19
• cDNA Data
  10
• Literature Summary
  2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  193
• RefSeq
  1

• Ensembl
  ENSMUSG00000097910 (Evidence)
• NCBI Gene
  75996

Representative Sequences			Length	Strain/Species
genomic	75996	NCBI Gene Model | MGI Sequence Detail	22146	C57BL/6J
transcript	NR_131041	RefSeq | MGI Sequence Detail	952	C57BL/6

Molecular
Reagents

• All nucleic 17

  cDNA 10

  Primer pair 7

Other
Accession IDs

MGI:6403633

References

• Summaries
  All 11

  Developmental Gene Expression 2

  Phenotypes 4
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:284183 George MR, et al., Minimal in vivo requirements for developmentally regulated cardiac long intergenic non-coding RNAs. Development. 2019 Dec 9;146(23):dev185314

TSS for Hdnr:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr77414	Chr8:57785146-57785166 (+)	-314 bp
Tssr77415	Chr8:57785460-57785490 (+)	5 bp
Tssr77416	Chr8:57794005-57794025 (+)	8,545 bp