Slain2 MGI Mouse Gene Detail - MGI:1923241 - SLAIN motif family, member 2

Symbol

Slain2
Name

SLAIN motif family, member 2
Synonyms

5033405K12Rik, 8030444K12Rik, mKIAA1458

Feature Type

protein coding gene
IDs

MGI:1923241
NCBI Gene: 75991
Alliance

genome feature page
Transcription Start Sites

6 TSS

Sequence Map

Chr5:73071705-73136184 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 38.44 cM
Mapping Data

2 experiments

SNPs within 2kb

1476 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923241	protein coding gene	Chr5:73071647-73136184 (+)
129S1/SvImJ	ENSMUSG00200035493	protein coding gene	Chr5:68729008-68793579 (+)
A/J	ENSMUSG00195031485	protein coding gene	Chr5:68053252-68117792 (+)
AKR/J	ENSMUSG00220003408	protein coding gene	Chr5:68164885-68229422 (+)
BALB/cJ	ENSMUSG00180021645	protein coding gene	Chr5:67810236-67874797 (+)
C3H/HeJ	ENSMUSG00175026636	protein coding gene	Chr5:69872153-69936205 (+)
C57BL/6NJ	ENSMUSG00215004730	protein coding gene	Chr5:68644361-68708889 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027291	protein coding gene	Chr5:65858763-65921615 (+)
CAST/EiJ	ENSTCUG00005029598	protein coding gene	Chr5:67619893-67684634 (+)
CBA/J	ENSMUSG00210022682	protein coding gene	Chr5:68810336-68874386 (+)
DBA/2J	ENSMUSG00185015894	protein coding gene	Chr5:70639985-70704037 (+)
FVB/NJ	ENSMUSG00205026895	protein coding gene	Chr5:67603477-67668037 (+)
JF1/MsJ	ENSUMUG00000005322	protein coding gene	Chr5:75119380-75183551 (+)
LP/J	ENSMUSG00230016647	protein coding gene	Chr5:75303363-75367929 (+)
NOD/ShiLtJ	ENSMUSG00190004021	protein coding gene	Chr5:67738859-67802907 (+)
NZO/HlLtJ	ENSMUSG00225009576	protein coding gene	Chr5:80373540-80438067 (+)
PWK/PhJ	ENSLUMG00010011953	protein coding gene	Chr5:67699090-67762977 (+)
SPRET/EiJ	ENSMSPG00010029791	protein coding gene	Chr5:69703770-69769153 (+)
WSB/EiJ	ENSIUOG00005016870	protein coding gene	Chr5:70595050-70656153 (+)

Human Ortholog

SLAIN2, SLAIN family member 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLAIN2, SLAIN family member 2
Synonyms

KIAA1458
Links

HGNC:29282

NCBI Gene ID: 57606

UniProt: Q9P270
Chr Location

4p11; chr4:48341472-48426201 (+) GRCh38

MGI Vertebrate Homology

Slain2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLAIN2
Gene Tree

Slain2

less

References

1 with disease annotations

less

Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
404 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

23
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

15
Radiation induced

1
Spontaneous

3
Targeted

1
Genomic Mutations

6 involving Slain2
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

33
GO References

6

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

641
Tissues

17
cDNA Data

90
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slain2l

less

All Sequences

65
RefSeq

6
UniProt

3
CCDS

CCDS19335.2, CCDS51517.1

Ensembl

ENSMUSG00000036087 (Evidence)
NCBI Gene

75991

			Length	Strain/Species	Flank
genomic	75991	NCBI Gene Model \| MGI Sequence Detail	64480	C57BL/6J	± kb
transcript	NM_153567	RefSeq \| MGI Sequence Detail	4865	C57BL/6
polypeptide	Q8CI08	UniProt \| EBI \| MGI Sequence Detail	581	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000030485 SLAIN motif-containing protein 2

(term hierarchy)
InterPro Domains

IPR026179 SLAIN motif-containing protein
GlyGen

Q8CI08 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

less

All nucleic 92

cDNA 91

Primer pair 1

Antibodies 1

Microarray probesets 7

less

MGI:2140939, MGI:2444168

Summaries

All 438

Developmental Gene Expression 4

Diseases 1

Gene Ontology 6

Phenotypes 404
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:390040 Dang L, et al., Activation of Intestinal Mast Cells Contributes to Gut Damage After Cardiac Arrest in Mice. Shock. 2026 Jan 1;65(1):85-92

TSS for Slain2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr46623	Chr5:73071607-73071646 (+)	-78 bp
Tssr46624	Chr5:73071650-73071692 (+)	-34 bp
Tssr46625	Chr5:73071695-73071726 (+)	6 bp
Tssr46626	Chr5:73071754-73071819 (+)	82 bp
Tssr46627	Chr5:73071850-73071863 (+)	152 bp
Tssr46628	Chr5:73071897-73071908 (+)	198 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24