Dock11 MGI Mouse Gene Detail - MGI:1923224 - dedicator of cytokinesis 11

Symbol

Dock11
Name

dedicator of cytokinesis 11
Synonyms

5033414A21Rik, Zizimin2

Feature Type

protein coding gene
IDs

MGI:1923224
NCBI Gene: 75974
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

ChrX:35152485-35340215 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 20.35 cM
Mapping Data

1 experiment

SNPs within 2kb

367 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923224	protein coding gene	ChrX:35150924-35340223 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035615	protein coding gene	ChrX:30778242-30967229 (+)
A/J	MGP_AJ_G0035592	protein coding gene	ChrX:30885238-31072451 (+)
AKR/J	MGP_AKRJ_G0035525	protein coding gene	ChrX:31516566-31708789 (+)
BALB/cJ	MGP_BALBcJ_G0035585	protein coding gene	ChrX:30609436-30806830 (+)
C3H/HeJ	MGP_C3HHeJ_G0035303	protein coding gene	ChrX:31098408-31287972 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036121	protein coding gene	ChrX:31395964-31583159 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032983	protein coding gene	ChrX:29028177-29215644 (+)
CAST/EiJ	MGP_CASTEiJ_G0034594	protein coding gene	ChrX:19259125-19449248 (+)
CBA/J	MGP_CBAJ_G0035272	protein coding gene	ChrX:32243443-32438831 (+)
DBA/2J	MGP_DBA2J_G0035424	protein coding gene	ChrX:30710192-30896550 (+)
FVB/NJ	MGP_FVBNJ_G0035370	protein coding gene	ChrX:30469382-30651463 (+)
LP/J	MGP_LPJ_G0035506	protein coding gene	ChrX:31154804-31335133 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035414	protein coding gene	ChrX:32681120-32903841 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036128	protein coding gene	ChrX:30751504-30934410 (+)
PWK/PhJ	MGP_PWKPhJ_G0034295	protein coding gene	ChrX:18765550-18950240 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034136	protein coding gene	ChrX:19745597-19939093 (+)
WSB/EiJ	MGP_WSBEiJ_G0034729	protein coding gene	ChrX:30556252-30745623 (+)

Human Ortholog

DOCK11, dedicator of cytokinesis 11

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DOCK11, dedicator of cytokinesis 11
Synonyms

ACG, ADMIDX, bB128O4.1, ZIZ2
Links

HGNC:23483

NCBI Gene ID: 139818

neXtProt AC: NX_Q5JSL3

UniProt: Q5JSL3
Chr Location

Xq24; chrX:118495815-118686163 (+) GRCh38

MGI Vertebrate Homology

Dock11 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DOCK11
Gene Tree

Dock11

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Phenotype Summary

14 phenotypes from 3 alleles in 3 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

2
Targeted

8
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous knockout leads to the reduction of the number of B cells in the spleen marginal zone and the increase in thymic CD4+ T cell percentage.

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All GO Annotations

13
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

751
Tissues

19
cDNA Data

41
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dock11

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All Sequences

53
RefSeq

12
UniProt

3
CCDS

CCDS40923.1

Ensembl

ENSMUSG00000031093 (Evidence)
NCBI Gene

75974

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031093	Ensembl Gene Model \| MGI Sequence Detail	187731	C57BL/6J	± kb
transcript	ENSMUST00000033419	Ensembl \| MGI Sequence Detail	6665	Not Applicable
polypeptide	ENSMUSP00000033419	Ensembl \| MGI Sequence Detail	2073	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000006618 dedicator of cytokinesis protein 11

(term hierarchy)
InterPro Domains

IPR016024 Armadillo-type fold

IPR027007 C2 DOCK-type domain

IPR035892 C2 domain superfamily

IPR026791 Dedicator of cytokinesis

IPR021816 Dedicator of cytokinesis C/D, N-terminal

IPR043161 Dedicator of cytokinesis, C-terminal, lobe A

IPR043162 Dedicator of cytokinesis, C-terminal, lobe C

IPR037809 Dedicator of cytokinesis D, C2 domain

IPR027357 DOCKER domain

IPR046769 DOCKER, Lobe A

IPR046770 DOCKER, Lobe B

IPR046773 DOCKER, Lobe C

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

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All nucleic 44

cDNA 44

Microarray probesets 3

Summaries

All 33

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:300632 Namekata K, et al., Roles of the DOCK-D family proteins in a mouse model of neuroinflammation. J Biol Chem. 2020 May 8;295(19):6710-6720

TSS for Dock11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr160723	ChrX:35152276-35152287 (+)	-203 bp
Tssr160724	ChrX:35152291-35152336 (+)	-171 bp
Tssr160725	ChrX:35152338-35152362 (+)	-135 bp
Tssr160726	ChrX:35152375-35152386 (+)	-104 bp
Tssr160727	ChrX:35152435-35152445 (+)	-45 bp
Tssr160728	ChrX:35152461-35152512 (+)	2 bp
Tssr160729	ChrX:35154891-35154895 (+)	2,408 bp
Tssr160730	ChrX:35161486-35161490 (+)	9,003 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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