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Tlcd4 Gene Detail
Summary
  • Symbol
    Tlcd4
  • Name
    TLC domain containing 4
  • Synonyms
    4930577M16Rik, C730036B01Rik, Tmem56
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923195
    NCBI Gene: 99887
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:120995657-121076756 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 52.94 cM, cytoband G3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    776 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923195
 protein coding gene Chr3:120995410-121076756 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027828
 protein coding gene Chr3:123372174-123457953 (-)
A/J MGP_AJ_G0027786
 protein coding gene Chr3:119267103-119350161 (-)
AKR/J MGP_AKRJ_G0027752
 protein coding gene Chr3:122298564-122391431 (-)
BALB/cJ MGP_BALBcJ_G0027798
 protein coding gene Chr3:119087893-119170286 (-)
C3H/HeJ MGP_C3HHeJ_G0027529
 protein coding gene Chr3:122693291-122787405 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028244
 protein coding gene Chr3:127855397-127943405 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025583
 protein coding gene Chr3:114709390-114786935 (-)
CAST/EiJ MGP_CASTEiJ_G0026985
 protein coding gene Chr3:122058578-122143227 (-)
CBA/J MGP_CBAJ_G0027504
 protein coding gene Chr3:132166690-132261259 (-)
DBA/2J MGP_DBA2J_G0027645
 protein coding gene Chr3:118420181-118506965 (-)
FVB/NJ MGP_FVBNJ_G0027613
 protein coding gene Chr3:116026855-116107590 (-)
LP/J MGP_LPJ_G0027755
 protein coding gene Chr3:124886782-124978607 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027643
 protein coding gene Chr3:139818685-139903785 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028300
 protein coding gene Chr3:121848645-121933234 (-)
PWK/PhJ MGP_PWKPhJ_G0026711
 protein coding gene Chr3:118101714-118192248 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026534
 protein coding gene Chr3:119898434-119991701 (-)
WSB/EiJ MGP_WSBEiJ_G0027065
 protein coding gene Chr3:122551633-122635443 (-)



Homology
more
  • Human Ortholog
    TLCD4, TLC domain containing 4
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TLCD4, TLC domain containing 4
  • Synonyms
    TMEM56
  • Links
    NCBI Gene ID: 148534
    neXtProt AC: NX_Q96MV1
    UniProt: Q96MV1

  • Chr Location
    1p21.3; chr1:95092517-95197607 (+)  GRCh38.p7
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Tlcd4
  • Find Mice (IMSR)
    15 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    748
  • Tissues
    19
  • cDNA Data
    14
  • Literature Summary
    3
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 99887 NCBI Gene Model | MGI Sequence Detail 81100 C57BL/6J ±  kb
transcript NM_001355678 RefSeq | MGI Sequence Detail 6549 C57BL/6  
polypeptide Q8CGF5 UniProt | EBI | MGI Sequence Detail 276 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 14
    Primer pair 1

    Microarray probesets 9
Other
Accession IDs
less
MGI:2139869, MGI:2139968
References
more
  • Summaries
    All 41
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 3
    Phenotypes 11
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
01/24/2023
MGI 6.22 		The Jackson Laboratory