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Exoc6b Gene Detail
Summary
  • Symbol
    Exoc6b
  • Name
    exocyst complex component 6B
  • Synonyms
    4930569O18Rik, G430127E12Rik, Sec15b, Sec15l2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923164
    NCBI Gene: 75914
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:84595469-85046495 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 36.55 cM, cytoband D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7206 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923164
 protein coding gene Chr6:84595468-85046524 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030946
 protein coding gene Chr6:85727555-86182481 (-)
A/J MGP_AJ_G0030915
 protein coding gene Chr6:82442814-82883628 (-)
AKR/J MGP_AKRJ_G0030843
 protein coding gene Chr6:84837636-85296346 (-)
BALB/cJ MGP_BALBcJ_G0030925
 protein coding gene Chr6:82468045-82910724 (-)
C3H/HeJ MGP_C3HHeJ_G0030785
 protein coding gene Chr6:99138400-99597143 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031385
 protein coding gene Chr6:88076434-88560674 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028571
 protein coding gene Chr6:80787116-81211544 (-)
CAST/EiJ MGP_CASTEiJ_G0030034
 protein coding gene Chr6:84863362-85320233 (-)
CBA/J MGP_CBAJ_G0030612
 protein coding gene Chr6:91554349-92047402 (-)
DBA/2J MGP_DBA2J_G0030765
 protein coding gene Chr6:81749157-82195592 (-)
FVB/NJ MGP_FVBNJ_G0030718
 protein coding gene Chr6:80962697-81401094 (-)
LP/J MGP_LPJ_G0030844
 protein coding gene Chr6:85720759-86174600 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030754
 protein coding gene Chr6:95775289-96252825 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031409
 protein coding gene Chr6:84659881-85116784 (-)
PWK/PhJ MGP_PWKPhJ_G0029749
 protein coding gene Chr6:80685546-81128336 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029577
 protein coding gene Chr6:83517101-83960636 (-)
WSB/EiJ MGP_WSBEiJ_G0030115
 protein coding gene Chr6:85101289-85550028 (-)



Homology
more
  • Human Ortholog
    EXOC6B, exocyst complex component 6B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EXOC6B, exocyst complex component 6B
  • Synonyms
    SEC15B, SEC15L2, SEMDJL3
  • Links
    NCBI Gene ID: 23233
    UniProt: Q9Y2D4

  • Chr Location
    2p13.2; chr2:72175984-72826041 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human EXOC6B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    96
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033769 Ensembl Gene Model | MGI Sequence Detail 451027 C57BL/6J ±  kb
    transcript ENSMUST00000160197 Ensembl | MGI Sequence Detail 5439 Not Applicable  
    polypeptide ENSMUSP00000125312 Ensembl | MGI Sequence Detail 810 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000007254 exocyst complex component 6B
      (term hierarchy)
    • InterPro Domains
      IPR042044 EXOC6/PINT-1/Sec15/Tip20, C-terminal, domain 2
      IPR007225 Exocyst complex component EXOC6/Sec15
      IPR042045 Exocyst complex component EXOC6/Sec15, C-terminal, domain 1
      IPR048359 Exocyst complex component EXOC6/Sec15, N-terminal domain
      IPR046361 Exocyst complex subunit EXOC6/Sec15, C-terminal
    • GlyGen
      A6H5Z3 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 96
      cDNA 96

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2443433
    References
    more
    • Summaries
      All 47
      Gene Ontology 5
      Phenotypes 17
    • Earliest
      J:33331 Nishiguchi S, et al., A catalogue of genes in mouse embryonal carcinoma F9 cells identified with expressed sequence tags. J Biochem. 1996 Apr;119(4):749-67
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/07/2025
    MGI 6.24     		The Jackson Laboratory