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Nln Gene Detail
Summary
  • Symbol
    Nln
  • Name
    neurolysin (metallopeptidase M3 family)
  • Synonyms
    4930472G13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923055
    NCBI Gene: 75805
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:104159565-104246122 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 56.16 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2625 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923055
 protein coding gene Chr13:104159558-104246170 (-)
129S1/SvImJ ENSMUSG00200008090
 protein coding gene Chr13:98573584-98660002 (-)
A/J ENSMUSG00195028901
 protein coding gene Chr13:99166660-99253110 (-)
AKR/J ENSMUSG00220025891
 protein coding gene Chr13:97589766-97674239 (-)
BALB/cJ ENSMUSG00180036085
 protein coding gene Chr13:99721034-99807463 (-)
C3H/HeJ ENSMUSG00175016804
 protein coding gene Chr13:99803854-99890436 (-)
C57BL/6NJ ENSMUSG00215028567
 protein coding gene Chr13:99806672-99893232 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018857
 protein coding gene Chr13:97594019-97680424 (-)
CAST/EiJ ENSTCUG00005011253
 protein coding gene Chr13:98927429-99015624 (-)
CBA/J ENSMUSG00210010714
 protein coding gene Chr13:99124810-99211398 (-)
DBA/2J ENSMUSG00185026368
 protein coding gene Chr13:102883516-102970125 (-)
FVB/NJ ENSMUSG00205017753
 protein coding gene Chr13:98572179-98658608 (-)
JF1/MsJ ENSUMUG00000009737
 protein coding gene Chr13:102478230-102564975 (-)
LP/J ENSMUSG00230005637
 protein coding gene Chr13:113043315-113129732 (-)
NOD/ShiLtJ ENSMUSG00190036848
 protein coding gene Chr13:99481799-99568235 (-)
NZO/HlLtJ ENSMUSG00225037141
 protein coding gene Chr13:105375369-105462703 (-)
PWK/PhJ ENSLUMG00010024938
 protein coding gene Chr13:98527259-98613700 (-)
SPRET/EiJ ENSMSPG00010008770
 protein coding gene Chr13:99936119-100021109 (-)
WSB/EiJ ENSIUOG00005030713
 protein coding gene Chr13:98566102-98652724 (-)



Homology
more
  • Human Ortholog
    NLN, neurolysin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NLN, neurolysin
  • Synonyms
    AGTBP, EP24.16, MEP, MOP
  • Links
    NCBI Gene ID: 57486
    UniProt: Q9BYT8

  • Chr Location
    5q12.3; chr5:65722205-65871725 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased glucose tolerance, insulin sensitivity, and gluconeogensis. Mice also show decreased body weight and run less in a low intensity regime to exhaustion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    601
  • Tissues
    4
  • cDNA Data
    89
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021710 Ensembl Gene Model | MGI Sequence Detail 86558 C57BL/6J ±  kb
    transcript ENSMUST00000109315 Ensembl | MGI Sequence Detail 4162 Not Applicable  
    polypeptide ENSMUSP00000104938 Ensembl | MGI Sequence Detail 704 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 90
      cDNA 89
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2145509
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 1
      Gene Ontology 13
      Phenotypes 15
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:345099 Wang X, et al., Identification and analysis of key circRNAs in the mouse embryonic ovary provides insight into primordial follicle development. BMC Genomics. 2024 Feb 3;25(1):139
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory