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Fbxw8 Gene Detail
Summary
  • Symbol
    Fbxw8
  • Name
    F-box and WD-40 domain protein 8
  • Synonyms
    4930438M06Rik, FBW6, FBW8, Fbx29, FBXO29
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923041
    NCBI Gene: 231672
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:118203046-118293523 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 57.92 cM, cytoband F
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1887 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923041
 protein coding gene Chr5:118203030-118293529 (-)
129S1/SvImJ ENSMUSG00200022771
 protein coding gene Chr5:111951201-112041496 (-)
A/J ENSMUSG00195008844
 protein coding gene Chr5:111464822-111562284 (-)
AKR/J ENSMUSG00220050160
 protein coding gene Chr5:110965648-111055946 (-)
BALB/cJ ENSMUSG00180043836
 protein coding gene Chr5:111586659-111676960 (-)
C3H/HeJ ENSMUSG00175029675
 protein coding gene Chr5:113583456-113673764 (-)
C57BL/6NJ ENSMUSG00215042758
 protein coding gene Chr5:111606964-111697476 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027649
 protein coding gene Chr5:111020243-111109913 (-)
CAST/EiJ ENSTCUG00005029304
 protein coding gene Chr5:110781283-110871319 (-)
CBA/J ENSMUSG00210007417
 protein coding gene Chr5:112334474-112424769 (-)
DBA/2J ENSMUSG00185049228
 protein coding gene Chr5:115397133-115487425 (-)
FVB/NJ ENSMUSG00205024155
 protein coding gene Chr5:111246286-111336660 (-)
JF1/MsJ ENSUMUG00000049835
 protein coding gene Chr5:118224000-118317072 (-)
LP/J ENSMUSG00230045166
 protein coding gene Chr5:119473689-119563982 (-)
NOD/ShiLtJ ENSMUSG00190032381
 protein coding gene Chr5:111279215-111369581 (-)
NZO/HlLtJ ENSMUSG00225013441
 protein coding gene Chr5:127146604-127236917 (-)
PWK/PhJ ENSLUMG00010036111
 protein coding gene Chr5:110117591-110208811 (-)
SPRET/EiJ ENSMSPG00010031465
 protein coding gene Chr5:113430469-113526579 (-)
WSB/EiJ ENSIUOG00005016868
 protein coding gene Chr5:113963196-114053505 (-)



Homology
more
  • Human Ortholog
    FBXW8, F-box and WD repeat domain containing 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FBXW8, F-box and WD repeat domain containing 8
  • Synonyms
    FBW6, FBW8, FBX29, FBXO29, FBXW6
  • Links
    NCBI Gene ID: 26259
    UniProt: Q8N3Y1

  • Chr Location
    12q24.22; chr12:116910839-117032498 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display partial late embryonic lethality with embryonic growth retardation and abnormal placental morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    69
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    631
  • Tissues
    19
  • cDNA Data
    13
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 231672 NCBI Gene Model | MGI Sequence Detail 90478 C57BL/6J ±  kb
    transcript NM_172721 RefSeq | MGI Sequence Detail 4978 C57BL/6  
    polypeptide Q8BIA4 UniProt | EBI | MGI Sequence Detail 598 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 13
      Antibodies 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 3
      Gene Ontology 12
      Phenotypes 20
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:380627 Masuda S, et al., TRAF7 determines circadian period through ubiquitination and degradation of DBP. Commun Biol. 2024 Oct 8;7(1):1280
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory