Plppr5 MGI Mouse Gene Detail - MGI:1923019 - phospholipid phosphatase related 5

Symbol

Plppr5
Name

phospholipid phosphatase related 5
Synonyms

4833424O15Rik, Lppr5

Feature Type

protein coding gene
IDs

MGI:1923019
NCBI Gene: 75769
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr3:117368274-117483157 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 51.21 cM, cytoband G2
Mapping Data

2 experiments

SNPs within 2kb

514 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923019	protein coding gene	Chr3:117278733-117483157 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027823	protein coding gene	Chr3:119559352-119672376 (+)
A/J	MGP_AJ_G0027781	protein coding gene	Chr3:115628554-115747043 (+)
AKR/J	MGP_AKRJ_G0027747	protein coding gene	Chr3:118542118-118662561 (+)
BALB/cJ	MGP_BALBcJ_G0027793	protein coding gene	Chr3:115467597-115582052 (+)
C3H/HeJ	MGP_C3HHeJ_G0027524	protein coding gene	Chr3:118926777-119048541 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028239	protein coding gene	Chr3:123917905-124041328 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025578	protein coding gene	Chr3:111252612-111363336 (+)
CAST/EiJ	MGP_CASTEiJ_G0026980	protein coding gene	Chr3:118225440-118345151 (+)
CBA/J	MGP_CBAJ_G0027499	protein coding gene	Chr3:128185624-128315678 (+)
DBA/2J	MGP_DBA2J_G0027640	protein coding gene	Chr3:114835338-114950369 (+)
FVB/NJ	MGP_FVBNJ_G0027608	protein coding gene	Chr3:112454884-112568960 (+)
LP/J	MGP_LPJ_G0027750	protein coding gene	Chr3:121108988-121232251 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027638	protein coding gene	Chr3:135576554-135706832 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028295	protein coding gene	Chr3:118085619-118211746 (+)
PWK/PhJ	MGP_PWKPhJ_G0026706	protein coding gene	Chr3:114484824-114611544 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026528	protein coding gene	Chr3:116098142-116225254 (+)
WSB/EiJ	MGP_WSBEiJ_G0027060	protein coding gene	Chr3:118791113-118918973 (+)

Human Ortholog

PLPPR5, phospholipid phosphatase related 5

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PLPPR5, phospholipid phosphatase related 5
Synonyms

LPPR5, PAP2, PAP2D, PRG5
Links

HGNC:31703

NCBI Gene ID: 163404

neXtProt AC: NX_Q32ZL2

UniProt: Q32ZL2
Chr Location

1p21.3; chr1:98890245-99227929 (-) GRCh38

MGI Vertebrate Homology

Plppr5 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PLPPR5
Gene Tree

Plppr5

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References

1 with disease annotations

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Phenotype Summary

31 phenotypes from 3 alleles in 3 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

6
Gene trapped

1
Radiation induced

1
Genomic Mutations

2 involving Plppr5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit increased susceptibility to hypoxia-ischemia injury and decreased responsiveness to melatonin treatment.

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All GO Annotations

8
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

782
Tissues

35
cDNA Data

10
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase plppr5

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All Sequences

62
RefSeq

14
UniProt

3
CCDS

CCDS17796.1, CCDS80009.1

Ensembl

ENSMUSG00000033342 (Evidence)
NCBI Gene

75769

			Length	Strain/Species	Flank
genomic	75769	NCBI Gene Model \| MGI Sequence Detail	114884	C57BL/6J	± kb
transcript	NM_001305451	RefSeq \| MGI Sequence Detail	4295	C57BL/6
polypeptide	Q8BJ52	UniProt \| EBI \| MGI Sequence Detail	321	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000009907 phospholipid phosphatase-related protein type 5

(term hierarchy)
InterPro Domains

IPR043216 Phosphatidate (PA) phosphatase-related

IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase

IPR036938 Phosphatidic acid phosphatase type 2/haloperoxidase superfamily

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All nucleic 11

cDNA 10

Other 1

Microarray probesets 7

Summaries

All 36

Developmental Gene Expression 4

Diseases 1

Gene Ontology 2

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:341278 Wang D, et al., Plppr5 gene inactivation causes a more severe neurological phenotype and abnormal mitochondrial homeostasis in a mouse model of juvenile seizure. Epilepsy Res. 2022 Jul;183:106944

TSS for Plppr5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr1029	Chr3:117368483-117368507 (+)	221 bp
Tssr31397	Chr3:117368531-117368554 (+)	269 bp
Tssr31398	Chr3:117368877-117368888 (+)	609 bp
Tssr31399	Chr3:117368917-117368931 (+)	650 bp
Tssr31400	Chr3:117369140-117369156 (+)	874 bp
Tssr31401	Chr3:117369168-117369183 (+)	902 bp
Tssr31402	Chr3:117427889-117427892 (+)	59,617 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23