About   Help   FAQ
Slc10a6 Gene Detail
Summary
  • Symbol
    Slc10a6
  • Name
    solute carrier family 10 (sodium/bile acid cotransporter family), member 6
  • Synonyms
    8430417G17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923000
    NCBI Gene: 75750
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:103753583-103777152 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 50.45 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    248 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923000
 protein coding gene Chr5:103753577-103777269 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029801
 protein coding gene Chr5:105246305-105270908 (-)
A/J MGP_AJ_G0029765
 protein coding gene Chr5:101293995-101317943 (-)
AKR/J MGP_AKRJ_G0029713
 protein coding gene Chr5:104559296-104586234 (-)
BALB/cJ MGP_BALBcJ_G0029777
 protein coding gene Chr5:102356455-102380071 (-)
C3H/HeJ MGP_C3HHeJ_G0029500
 protein coding gene Chr5:104968164-104992540 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030232
 protein coding gene Chr5:109531532-109560027 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027467
 protein coding gene Chr5:96441868-96465958 (-)
CAST/EiJ MGP_CASTEiJ_G0028911
 protein coding gene Chr5:103671563-103697641 (-)
CBA/J MGP_CBAJ_G0029470
 protein coding gene Chr5:113358477-113384388 (-)
DBA/2J MGP_DBA2J_G0029614
 protein coding gene Chr5:101487021-101510693 (-)
FVB/NJ MGP_FVBNJ_G0029573
 protein coding gene Chr5:100286917-100311245 (-)
LP/J MGP_LPJ_G0029702
 protein coding gene Chr5:105820718-105844370 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029602
 protein coding gene Chr5:118307748-118331967 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030265
 protein coding gene Chr5:104094437-104120352 (-)
PWK/PhJ MGP_PWKPhJ_G0028629
 protein coding gene Chr5:99939959-99964432 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028464
 protein coding gene Chr5:101749588-101773679 (-)
WSB/EiJ MGP_WSBEiJ_G0028989
 protein coding gene Chr5:104465861-104489356 (-)



Homology
more
  • Human Ortholog
    SLC10A6, solute carrier family 10 member 6
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC10A6, solute carrier family 10 member 6
  • Synonyms
    SOAT
  • Links
    NCBI Gene ID: 345274
    neXtProt AC: NX_Q3KNW5
    UniProt: Q3KNW5

  • Chr Location
    4q21.3; chr4:86823468-86849384 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display elevated serum cholesterol sulfate levels in males and normal fertility and spermatogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    726
  • Tissues
    20
  • cDNA Data
    18
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 75750 NCBI Gene Model | MGI Sequence Detail 23570 C57BL/6J ±  kb
    transcript NM_029415 RefSeq | MGI Sequence Detail 2001 C57BL/6  
    polypeptide Q9CXB2 UniProt | EBI | MGI Sequence Detail 373 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000014922 sodium-dependent organic anion transporter
      (term hierarchy)
    • InterPro Domains
      IPR004710 Bile acid:sodium symporter
      IPR002657 Bile acid:sodium symporter/arsenical resistance protein Acr3
      IPR038770 Sodium/solute symporter superfamily
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 18
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2141304
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 8
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:301761 Bakhaus K, et al., Sodium-dependent organic anion transporter (Slc10a6(-/-)) knockout mice show normal spermatogenesis and reproduction, but elevated serum levels for cholesterol sulfate. J Steroid Biochem Mol Biol. 2018 May;179:45-54
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory