Morc4 MGI Mouse Gene Detail - MGI:1922996

Symbol

Morc4
Name

microrchidia 4
Synonyms

1600017G11Rik, 5630401M14Rik, Zcwcc2

Feature Type

protein coding gene
IDs

MGI:1922996
NCBI Gene: 75746
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

ChrX:138722381-138772426 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 61.35 cM, cytoband F1
Mapping Data

3 experiments

SNPs within 2kb

1380 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922996	protein coding gene	ChrX:138722381-138772440 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0036129	protein coding gene	ChrX:137337484-137390100 (-)
A/J	MGP_AJ_G0036107	protein coding gene	ChrX:136719947-136769991 (-)
AKR/J	MGP_AKRJ_G0036032	protein coding gene	ChrX:141111467-141162691 (-)
BALB/cJ	MGP_BALBcJ_G0036097	protein coding gene	ChrX:135062371-135112216 (-)
C3H/HeJ	MGP_C3HHeJ_G0035806	protein coding gene	ChrX:137369319-137420419 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0036622	protein coding gene	ChrX:141376060-141427043 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033446	protein coding gene	ChrX:128470729-128517156 (-)
CAST/EiJ	MGP_CASTEiJ_G0035097	protein coding gene	ChrX:118166515-118221150 (-)
CBA/J	MGP_CBAJ_G0035783	protein coding gene	ChrX:145706092-145756158 (-)
DBA/2J	MGP_DBA2J_G0035940	protein coding gene	ChrX:135889893-135939913 (-)
FVB/NJ	MGP_FVBNJ_G0035874	protein coding gene	ChrX:135123721-135174782 (-)
LP/J	MGP_LPJ_G0036031	protein coding gene	ChrX:138307811-138359588 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035911	protein coding gene	ChrX:153221551-153285639 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036658	protein coding gene	ChrX:136648409-136701213 (-)
PWK/PhJ	MGP_PWKPhJ_G0034790	protein coding gene	ChrX:115091054-115145594 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0034616	protein coding gene	ChrX:118704541-118759326 (-)
WSB/EiJ	MGP_WSBEiJ_G0035232	protein coding gene	ChrX:134973874-135024442 (-)

Human Ortholog

MORC4, MORC family CW-type zinc finger 4

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MORC4, MORC family CW-type zinc finger 4
Synonyms

dJ75H8.2, ZCW4, ZCWCC2
Links

HGNC:23485

NCBI Gene ID: 79710

UniProt: Q8TE76
Chr Location

Xq22.3; chrX:106813871-107000212 (-) GRCh38

MGI Vertebrate Homology

Morc4 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: MORC4
Gene Tree

Morc4

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

2
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

14
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

730
Tissues

15
cDNA Data

44
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

67
RefSeq

8
UniProt

7
CCDS

CCDS53203.1, CCDS57777.1

Ensembl

ENSMUSG00000031434 (Evidence)
NCBI Gene

75746

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031434	Ensembl Gene Model \| MGI Sequence Detail	50046	C57BL/6J	± kb
transcript	ENSMUST00000087401	Ensembl \| MGI Sequence Detail	3862	Not Applicable
polypeptide	ENSMUSP00000084663	Ensembl \| MGI Sequence Detail	928	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000032241 MORC family CW-type zinc finger protein 4

(term hierarchy)
InterPro Domains

IPR036890 Histidine kinase/HSP90-like ATPase superfamily

IPR045261 MICRORCHIDIA ATPase family

IPR041006 Morc, S5 domain 2-like

IPR011124 Zinc finger, CW-type
GlyGen

Q8BMD7 1 site

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All nucleic 46

Genomic 2

cDNA 44

Microarray probesets 4

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MGI:1923745, MGI:3034488

Summaries

All 38

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Morc4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr164226	ChrX:138772386-138772419 (-)	23 bp
Tssr164225	ChrX:138772364-138772379 (-)	54 bp
Tssr164224	ChrX:138772256-138772264 (-)	166 bp
Tssr164223	ChrX:138772227-138772238 (-)	193 bp
Tssr164222	ChrX:138735487-138735493 (-)	36,936 bp
Tssr164221	ChrX:138723163-138723168 (-)	49,260 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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