About   Help   FAQ
Wnk2 Gene Detail
Summary
  • Symbol
    Wnk2
  • Name
    WNK lysine deficient protein kinase 2
  • Synonyms
    1810073P09Rik, ESTM15, mKIAA1760, X83337
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922857
    NCBI Gene: 75607
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:49189779-49301490 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 25.07 cM, cytoband B1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2228 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922857
 protein coding gene Chr13:49189778-49302110 (-)
129S1/SvImJ ENSMUSG00200035664
 protein coding gene Chr13:46468533-46579470 (-)
A/J ENSMUSG00195029007
 protein coding gene Chr13:45518141-45629085 (-)
AKR/J ENSMUSG00220008960
 protein coding gene Chr13:45334079-45445014 (-)
BALB/cJ ENSMUSG00180008516
 protein coding gene Chr13:45820408-45931347 (-)
C3H/HeJ ENSMUSG00175026010
 protein coding gene Chr13:45790885-45901820 (-)
C57BL/6NJ ENSMUSG00215005330
 protein coding gene Chr13:45937435-46048380 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018497
 protein coding gene Chr13:44270777-44378177 (-)
CAST/EiJ ENSTCUG00005028774
 protein coding gene Chr13:45850737-45960504 (-)
CBA/J ENSMUSG00210026766
 protein coding gene Chr13:45796264-45907197 (-)
DBA/2J ENSMUSG00185029428
 protein coding gene Chr13:46610277-46721209 (-)
FVB/NJ ENSMUSG00205011457
 protein coding gene Chr13:45575296-45688205 (-)
JF1/MsJ ENSUMUG00000007630
 protein coding gene Chr13:46136862-46248580 (-)
LP/J ENSMUSG00230027413
 protein coding gene Chr13:55931094-56042033 (-)
NOD/ShiLtJ ENSMUSG00190010889
 protein coding gene Chr13:46015155-46126084 (-)
NZO/HlLtJ ENSMUSG00225035615
 protein coding gene Chr13:49681454-49792387 (-)
PWK/PhJ ENSLUMG00010019945
 protein coding gene Chr13:44994252-45105181 (-)
SPRET/EiJ ENSMSPG00010026536
 protein coding gene Chr13:45129336-45237874 (-)
WSB/EiJ ENSIUOG00005026278
 protein coding gene Chr13:45154625-45265578 (-)



Homology
more
  • Human Ortholog
    WNK2, WNK lysine deficient protein kinase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WNK2, WNK lysine deficient protein kinase 2
  • Synonyms
    NY-CO-43, P/OKcl.13, PRKWNK2, SDCCAG43
  • Links
    NCBI Gene ID: 65268
    UniProt: Q9Y3S1

  • Chr Location
    9q22.31; chr9:93184122-93320572 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    699
  • Tissues
    42
  • cDNA Data
    71
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037989 Ensembl Gene Model | MGI Sequence Detail 111712 C57BL/6J ±  kb
transcript ENSMUST00000091623 Ensembl | MGI Sequence Detail 6897 Not Applicable  
polypeptide ENSMUSP00000089212 Ensembl | MGI Sequence Detail 2213 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    12 Sequences
  • Protein Ontology
    PR:000017432 serine/threonine-protein kinase WNK2
    (term hierarchy)
  • EC
    2.7.11.1
  • InterPro Domains
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain superfamily
    IPR008271 Serine/threonine-protein kinase, active site
    IPR024678 Serine/threonine-protein kinase OSR1/WNK, CCT domain
    IPR056865 Serine/threonine-protein kinase WNK, CCTL2 domain
    IPR050588 With No Lysine (K) Ser/Thr Protein Kinase
  • GlyGen
    Q3UH66 9 sites, 1 O-linked glycan (4 sites)
Molecular
Reagents
less
  • All nucleic 71
    cDNA 71

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-28128, MGI:104834, MGI:2145415
References
more
  • Summaries
    All 48
    Developmental Gene Expression 4
    Gene Ontology 8
    Phenotypes 12
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory