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Oplah Gene Detail
Summary
  • Symbol
    Oplah
  • Name
    5-oxoprolinase (ATP-hydrolysing)
  • Synonyms
    MGC:28663, MGC:36824
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922725
    NCBI Gene: 75475
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:76180801-76212215 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 35.67 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    726 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922725
 protein coding gene Chr15:76180801-76215381 (-)
129S1/SvImJ ENSMUSG00200049092
 protein coding gene Chr15:73294997-73326407 (-)
A/J ENSMUSG00195049929
 protein coding gene Chr15:73269442-73300871 (-)
AKR/J ENSMUSG00220050215
 protein coding gene Chr15:73280465-73311893 (-)
BALB/cJ ENSMUSG00180052111
 protein coding gene Chr15:73094602-73126017 (-)
C3H/HeJ ENSMUSG00175052306
 protein coding gene Chr15:73458022-73489446 (-)
C57BL/6NJ ENSMUSG00215046762
 protein coding gene Chr15:73186823-73218239 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019918
 protein coding gene Chr15:70245558-70277287 (-)
CAST/EiJ ENSTCUG00005045209
 protein coding gene Chr15:72799880-72831482 (-)
CBA/J ENSMUSG00210034549
 protein coding gene Chr15:73233265-73264683 (-)
DBA/2J ENSMUSG00185046302
 protein coding gene Chr15:73210437-73241854 (-)
FVB/NJ ENSMUSG00205045988
 protein coding gene Chr15:72962694-72994136 (-)
JF1/MsJ ENSUMUG00000055011
 protein coding gene Chr15:72860379-72892366 (-)
LP/J ENSMUSG00230052376
 protein coding gene Chr15:76575936-76607377 (-)
NOD/ShiLtJ ENSMUSG00190045992
 protein coding gene Chr15:73215375-73246756 (-)
NZO/HlLtJ ENSMUSG00225051628
 protein coding gene Chr15:76880473-76911918 (-)
PWK/PhJ ENSLUMG00010049063
 protein coding gene Chr15:73145772-73184309 (-)
SPRET/EiJ ENSMSPG00010049741
 protein coding gene Chr15:74759786-74791659 (-)
WSB/EiJ ENSIUOG00005046739
 protein coding gene Chr15:73273303-73304666 (-)



Homology
more
  • Human Ortholog
    OPLAH, 5-oxoprolinase, ATP-hydrolysing
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OPLAH, 5-oxoprolinase, ATP-hydrolysing
  • Synonyms
    5-Opase, OPLA, OPLAHD
  • Links
    NCBI Gene ID: 26873
    UniProt: O14841

  • Chr Location
    8q24.3; chr8:144050322-144064091 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    705
  • Tissues
    104
  • cDNA Data
    64
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022562 Ensembl Gene Model | MGI Sequence Detail 31415 C57BL/6J ±  kb
    transcript ENSMUST00000171340 Ensembl | MGI Sequence Detail 4081 Not Applicable  
    polypeptide ENSMUSP00000129100 Ensembl | MGI Sequence Detail 1288 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 64
      cDNA 64

      Microarray probesets 4
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 10
      Phenotypes 35
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory