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Mettl5 Gene Detail
Summary
  • Symbol
    Mettl5
  • Name
    methyltransferase 5, N6-adenosine
  • Synonyms
    2810410A08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922672
    NCBI Gene: 75422
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:69701542-69715959 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 40.95 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    74 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922672
 protein coding gene Chr2:69701539-69717961 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025808
 protein coding gene Chr2:69867902-69887793 (-)
A/J MGP_AJ_G0025785
 protein coding gene Chr2:67174667-67189603 (-)
AKR/J MGP_AKRJ_G0025754
 protein coding gene Chr2:68992967-69009385 (-)
BALB/cJ MGP_BALBcJ_G0025780
 protein coding gene Chr2:67335767-67350220 (-)
C3H/HeJ MGP_C3HHeJ_G0025540
 protein coding gene Chr2:69227168-69241770 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026227
 protein coding gene Chr2:71982736-71998445 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023630
 protein coding gene Chr2:64400270-64415356 (-)
CAST/EiJ MGP_CASTEiJ_G0025004
 protein coding gene Chr2:69340084-69355891 (-)
CBA/J MGP_CBAJ_G0025520
 protein coding gene Chr2:74640310-74654062 (-)
DBA/2J MGP_DBA2J_G0025651
 protein coding gene Chr2:66808161-66822140 (-)
FVB/NJ MGP_FVBNJ_G0025614
 protein coding gene Chr2:66188292-66204117 (-)
LP/J MGP_LPJ_G0025740
 protein coding gene Chr2:69729775-69746776 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025643
 protein coding gene Chr2:76700329-76717429 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026284
 protein coding gene Chr2:69078018-69093298 (-)
PWK/PhJ MGP_PWKPhJ_G0024745
 protein coding gene Chr2:66659107-66673463 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024552
 protein coding gene Chr2:69309706-69327520 (-)
WSB/EiJ MGP_WSBEiJ_G0025072
 protein coding gene Chr2:69508920-69524353 (-)



Homology
more
  • Human Ortholog
    METTL5, methyltransferase 5, N6-adenosine
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    METTL5, methyltransferase 5, N6-adenosine
  • Synonyms
    HSPC133, MRT72
  • Links
    NCBI Gene ID: 29081
    neXtProt AC: NX_Q9NRN9
    UniProt: Q9NRN9

  • Chr Location
    2q31.1; chr2:169810081-169824931 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human METTL5 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display partial preweaning lethality, reduced body weight, hypoactivity, craniofacial abnormalities, and male infertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000051730 Ensembl Gene Model | MGI Sequence Detail 14418 C57BL/6J ±  kb
    transcript ENSMUST00000060447 Ensembl | MGI Sequence Detail 968 Not Applicable  
    polypeptide ENSMUSP00000050907 Ensembl | MGI Sequence Detail 209 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000010350 rRNA N6-adenosine-methyltransferase METTL5
      (term hierarchy)
    • EC
      2.1.1.-
    • InterPro Domains
      IPR002052 DNA methylase, N-6 adenine-specific, conserved site
      IPR007848 Methyltransferase small domain
      IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 3
    References
    more
    • Summaries
      All 41
      Gene Ontology 10
      Phenotypes 13
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:330528 Zhang L, et al., Inhibition of METTL5 improves preimplantation development of mouse somatic cell nuclear transfer embryos. Reproduction. 2022 Nov 1;164(5):221-230
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory