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Secisbp2 Gene Detail
Summary
  • Symbol
    Secisbp2
  • Name
    SECIS binding protein 2
  • Synonyms
    2210413N07Rik, 2810012K13Rik, SBP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922670
    NCBI Gene: 75420
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:51805733-51838080 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 26.12 cM, cytoband B1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    913 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922670
 protein coding gene Chr13:51805721-51838080 (+)
129S1/SvImJ ENSMUSG00200035471
 protein coding gene Chr13:48665709-48698056 (+)
A/J ENSMUSG00195028746
 protein coding gene Chr13:48135983-48168334 (+)
AKR/J ENSMUSG00220009002
 protein coding gene Chr13:47695768-47728585 (+)
BALB/cJ ENSMUSG00180008609
 protein coding gene Chr13:48385709-48418057 (+)
C3H/HeJ ENSMUSG00175027463
 protein coding gene Chr13:48168725-48201072 (+)
C57BL/6NJ ENSMUSG00215006073
 protein coding gene Chr13:48205070-48237419 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018518
 protein coding gene Chr13:46868588-46901541 (+)
CAST/EiJ ENSTCUG00005028601
 protein coding gene Chr13:48570947-48603124 (+)
CBA/J ENSMUSG00210027284
 protein coding gene Chr13:48378942-48411290 (+)
DBA/2J ENSMUSG00185030572
 protein coding gene Chr13:49227905-49260257 (+)
FVB/NJ ENSMUSG00205009843
 protein coding gene Chr13:48033807-48066157 (+)
JF1/MsJ ENSUMUG00000011045
 protein coding gene Chr13:48621972-48654939 (+)
LP/J ENSMUSG00230027575
 protein coding gene Chr13:58548552-58580899 (+)
NOD/ShiLtJ ENSMUSG00190010991
 protein coding gene Chr13:48263160-48295509 (+)
NZO/HlLtJ ENSMUSG00225033716
 protein coding gene Chr13:52298981-52331328 (+)
PWK/PhJ ENSLUMG00010019785
 protein coding gene Chr13:47478470-47511239 (+)
SPRET/EiJ ENSMSPG00010026277
 protein coding gene Chr13:47890938-47924842 (+)
WSB/EiJ ENSIUOG00005025996
 protein coding gene Chr13:47656007-47688013 (+)



Homology
more
  • Human Ortholog
    SECISBP2, SECIS binding protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SECISBP2, SECIS binding protein 2
  • Synonyms
    SBP2, THMA1
  • Links
    NCBI Gene ID: 79048
    UniProt: Q96T21

  • Chr Location
    9q22.2; chr9:89318460-89367117 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SECISBP2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 5 alleles in 5 genetic backgrounds
    3 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit complete preweaning lethality while heterozygotes exhibit reduced serum selenium levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    605
  • Tissues
    4
  • cDNA Data
    55
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035139 Ensembl Gene Model | MGI Sequence Detail 32348 C57BL/6J ±  kb
    transcript ENSMUST00000040117 Ensembl | MGI Sequence Detail 3328 Not Applicable  
    polypeptide ENSMUSP00000045740 Ensembl | MGI Sequence Detail 858 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000014601 selenocysteine insertion sequence-binding protein 2
      (term hierarchy)
    • InterPro Domains
      IPR029064 Ribosomal protein eL30-like superfamily
      IPR004038 Ribosomal protein eL8/eL30/eS12/Gadd45
      IPR040051 Selenocysteine insertion sequence-binding protein 2
    • GlyGen
      Q3U1C4 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 57
      cDNA 57

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1919610
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 2
      Gene Ontology 14
      Phenotypes 24
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory