Nxnl2 MGI Mouse Gene Detail - MGI:1922374

Symbol

Nxnl2
Name

nucleoredoxin-like 2
Synonyms

4930519N16Rik

Feature Type

protein coding gene
IDs

MGI:1922374
NCBI Gene: 75124
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr13:51325058-51329224 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 26.08 cM, cytoband B1
Mapping Data

2 experiments

SNPs within 2kb

213 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922374	protein coding gene	Chr13:51324256-51329227 (+)
129S1/SvImJ	ENSMUSG00200035215	protein coding gene	Chr13:48184397-48188563 (+)
A/J	ENSMUSG00195028503	protein coding gene	Chr13:47654580-47658746 (+)
AKR/J	ENSMUSG00220008946	protein coding gene	Chr13:47224765-47228923 (+)
BALB/cJ	ENSMUSG00180008419	protein coding gene	Chr13:47904290-47908464 (+)
C3H/HeJ	ENSMUSG00175027112	protein coding gene	Chr13:47687400-47691566 (+)
C57BL/6NJ	ENSMUSG00215005016	protein coding gene	Chr13:47723657-47727823 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018514	protein coding gene	Chr13:46384390-46388602 (+)
CAST/EiJ	ENSTCUG00005030298	protein coding gene	Chr13:48097670-48101874 (+)
CBA/J	ENSMUSG00210026939	protein coding gene	Chr13:47897619-47901789 (+)
DBA/2J	ENSMUSG00185031594	protein coding gene	Chr13:48746577-48750743 (+)
FVB/NJ	ENSMUSG00205011313	protein coding gene	Chr13:47552462-47556628 (+)
JF1/MsJ	ENSUMUG00000009731	protein coding gene	Chr13:48139718-48143926 (+)
LP/J	ENSMUSG00230028120	protein coding gene	Chr13:58067302-58071468 (+)
NOD/ShiLtJ	ENSMUSG00190011687	protein coding gene	Chr13:47781831-47785997 (+)
NZO/HlLtJ	ENSMUSG00225034364	protein coding gene	Chr13:51817716-51821882 (+)
PWK/PhJ	ENSLUMG00010020210	protein coding gene	Chr13:46995598-46999775 (+)
SPRET/EiJ	ENSMSPG00010027233	protein coding gene	Chr13:47409225-47413309 (+)
WSB/EiJ	ENSIUOG00005025586	protein coding gene	Chr13:47179231-47183385 (+)

Human Ortholog

NXNL2, nucleoredoxin like 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NXNL2, nucleoredoxin like 2
Synonyms

C9orf121, RDCVF2, RdCVF2L
Links

HGNC:30482

NCBI Gene ID: 158046

UniProt: Q5VZ03
Chr Location

9q22.1; chr9:88534033-88584510 (+) GRCh38

MGI Vertebrate Homology

Nxnl2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NXNL2
Gene Tree

Nxnl2

less

Phenotype Summary

14 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

4
Genomic Mutations

1 involving Nxnl2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

5 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a targeted allele exhibit impaired cone and rod electrophysiology, reduced cone density, short photoreceptor outer segment, impaired olfaction and reduced survival of olfactory neurons.

less

All GO Annotations

6
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

8

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nxnl2

ZFIN nxnl2

less

All Sequences

38
RefSeq

10
UniProt

1
CCDS

CCDS26511.1

Ensembl

ENSMUSG00000021396 (Evidence)
NCBI Gene

75124

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021396	Ensembl Gene Model \| MGI Sequence Detail	4167	C57BL/6J	± kb
transcript	ENSMUST00000021828	Ensembl \| MGI Sequence Detail	1167	Not Applicable
polypeptide	ENSMUSP00000021828	Ensembl \| MGI Sequence Detail	156	Not Applicable

less

UniProt

1 Sequence
Protein Ontology

PR:000011541 nucleoredoxin-like protein 2

(term hierarchy)
InterPro Domains

IPR029519 Nucleoredoxin-like protein 2

IPR012336 Thioredoxin-like fold

IPR036249 Thioredoxin-like superfamily

less

All nucleic 8

cDNA 8

Microarray probesets 3

Summaries

All 31

Gene Ontology 3

Phenotypes 13
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Nxnl2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119754	Chr13:51325270-51325294 (+)	224 bp
Tssr119755	Chr13:51325331-51325341 (+)	278 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29