About   Help   FAQ
Usp50 Gene Detail
Summary
  • Symbol
    Usp50
  • Name
    ubiquitin specific peptidase 50
  • Synonyms
    1700086G18Rik, 4930511O11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922333
    NCBI Gene: 75083
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:126602970-126625380 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 61.76 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    659 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922333
 protein coding gene Chr2:126551016-126625390 (-)
129S1/SvImJ ENSMUSG00200043826
 protein coding gene Chr2:123634883-123685403 (-)
A/J ENSMUSG00195029500
 protein coding gene Chr2:123655344-123705879 (-)
AKR/J ENSMUSG00220037234
 protein coding gene Chr2:123421121-123471649 (-)
BALB/cJ ENSMUSG00180047503
 protein coding gene Chr2:123442258-123492795 (-)
C3H/HeJ ENSMUSG00175038804
 protein coding gene Chr2:123995144-124045555 (-)
C57BL/6NJ ENSMUSG00215018966
 protein coding gene Chr2:123496237-123546659 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024242
 protein coding gene Chr2:119453455-119472273 (-)
CAST/EiJ ENSTCUG00005038907
 protein coding gene Chr2:122790267-122840657 (-)
CBA/J ENSMUSG00210031542
 protein coding gene Chr2:123845727-123896151 (-)
DBA/2J ENSMUSG00185030349
 protein coding gene Chr2:123499776-123550219 (-)
FVB/NJ ENSMUSG00205027950
 protein coding gene Chr2:122657931-122708468 (-)
JF1/MsJ ENSUMUG00000009575
 protein coding gene Chr2:123349728-123400455 (-)
LP/J ENSMUSG00230035489
 protein coding gene Chr2:125270334-125320844 (-)
NOD/ShiLtJ ENSMUSG00190013766
 protein coding gene Chr2:123628129-123678648 (-)
NZO/HlLtJ ENSMUSG00225026555
 protein coding gene Chr2:133176488-133227013 (-)
PWK/PhJ ENSLUMG00010040310
 protein coding gene Chr2:123236874-123286984 (-)
SPRET/EiJ ENSMSPG00010031078
 protein coding gene Chr2:125668167-125718251 (-)
WSB/EiJ ENSIUOG00005038039
 protein coding gene Chr2:123429415-123480816 (-)



Homology
more
  • Human Ortholog
    USP50, ubiquitin specific peptidase 50
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USP50, ubiquitin specific peptidase 50
  • Links
    NCBI Gene ID: 373509
    UniProt: Q70EL3

  • Chr Location
    15q21.2; chr15:50493025-50546708 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    19
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 75083 NCBI Gene Model | MGI Sequence Detail 22411 C57BL/6J ±  kb
transcript NM_029163 RefSeq | MGI Sequence Detail 1748 C57BL/6  
polypeptide Q6P8X6 UniProt | EBI | MGI Sequence Detail 390 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000017190 ubiquitin carboxyl-terminal hydrolase 50
    (term hierarchy)
  • EC
    3.4.19.12
  • InterPro Domains
    IPR038765 Papain-like cysteine peptidase superfamily
    IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
    IPR050185 Ubiquitin carboxyl-terminal hydrolase
    IPR018200 Ubiquitin specific protease, conserved site
    IPR028889 Ubiquitin specific protease USP, catalytic domain
Molecular
Reagents
less
  • All nucleic 19
    cDNA 19

    Microarray probesets 3
Other
Accession IDs
less
MGI:1923866
References
more
  • Summaries
    All 42
    Gene Ontology 9
    Phenotypes 12
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:380621 Jiang H, et al., Pristimerin suppresses AIM2 inflammasome by modulating AIM2-PYCARD/ASC stability via selective autophagy to alleviate tendinopathy. Autophagy. 2024 Jan;20(1):76-93
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory