Rnase10 MGI Mouse Gene Detail - MGI:1922269 - ribonuclease, RNase A family, 10 (non-active)

Symbol

Rnase10
Name

ribonuclease, RNase A family, 10 (non-active)
Synonyms

4930474F22Rik

Feature Type

protein coding gene
IDs

MGI:1922269
NCBI Gene: 75019
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr14:51245208-51248215 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 26.34 cM, cytoband C1
Mapping Data

3 experiments

SNPs within 2kb

146 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922269	protein coding gene	Chr14:51245208-51248218 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021266	protein coding gene	Chr14:44949610-44952617 (+)
A/J	MGP_AJ_G0021220	protein coding gene	Chr14:43608505-43611512 (+)
AKR/J	MGP_AKRJ_G0021196	protein coding gene	Chr14:45256829-45259836 (+)
BALB/cJ	MGP_BALBcJ_G0021223	protein coding gene	Chr14:43725286-43728293 (+)
C3H/HeJ	MGP_C3HHeJ_G0021005	protein coding gene	Chr14:45079303-45082310 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021660	protein coding gene	Chr14:46816468-46819475 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019212	protein coding gene	Chr14:42944903-42947910 (+)
CAST/EiJ	MGP_CASTEiJ_G0020529	protein coding gene	Chr14:42155208-42158215 (+)
CBA/J	MGP_CBAJ_G0020972	protein coding gene	Chr14:48272386-48275393 (+)
DBA/2J	MGP_DBA2J_G0021096	protein coding gene	Chr14:43500159-43503166 (+)
FVB/NJ	MGP_FVBNJ_G0021077	protein coding gene	Chr14:43126815-43129822 (+)
LP/J	MGP_LPJ_G0021164	protein coding gene	Chr14:45243557-45246564 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021105	protein coding gene	Chr14:47759084-47762091 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021689	protein coding gene	Chr14:44738900-44741907 (+)
PWK/PhJ	MGP_PWKPhJ_G0020279	protein coding gene	Chr14:40405723-40408730 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020104	protein coding gene	Chr14:40914027-40917010 (+)
WSB/EiJ	MGP_WSBEiJ_G0020582	protein coding gene	Chr14:44939915-44942922 (+)

Human Ortholog

RNASE10, ribonuclease A family member 10 (inactive)

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RNASE10, ribonuclease A family member 10 (inactive)
Synonyms

RAH1, RNASE9
Links

HGNC:19275

NCBI Gene ID: 338879

UniProt: Q5GAN6
Chr Location

14q11.2; chr14:20504233-20513884 (+) GRCh38

MGI Vertebrate Homology

Rnase10 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: RNASE10
Gene Tree

Rnase10

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
12 phenotypes from multigenic genotypes
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

3
Targeted

4
Genomic Mutations

2 involving Rnase10
Incidental Mutations

APF
Find Mice (IMSR)

12 strains or lines available

Homozygous disruption of this gene leads to decreased bone mineral density, alterations in B cell, T cell and NK cell number, and abnormal circulating glucose, creatinine, chloride and serum albumin levels.

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All GO Annotations

6
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

4

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

40
RefSeq

8
UniProt

4
CCDS

CCDS27030.1, CCDS49480.1

Ensembl

ENSMUSG00000021872 (Evidence)
NCBI Gene

75019

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021872	Ensembl Gene Model \| MGI Sequence Detail	3008	C57BL/6J	± kb
transcript	ENSMUST00000022424	Ensembl \| MGI Sequence Detail	1629	Not Applicable
polypeptide	ENSMUSP00000022424	Ensembl \| MGI Sequence Detail	245	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000014043 ribonuclease-like protein 10

(term hierarchy)
InterPro Domains

IPR001427 Pancreatic ribonuclease

IPR023412 Ribonuclease A-domain

IPR036816 Ribonuclease A-like domain superfamily
GlyGen

Q9D5A9 2 sites

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All nucleic 4

cDNA 4

Microarray probesets 2

Summaries

All 36

Gene Ontology 2

Phenotypes 16
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:364178 Shaffer JF, et al., Epididymis-specific RNase A family genes regulate fertility and small RNA processing. J Biol Chem. 2024 Oct 28;300(12):107933

TSS for Rnase10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125391	Chr14:51245368-51245377 (+)	165 bp
Tssr125392	Chr14:51245398-51245405 (+)	194 bp
Tssr125393	Chr14:51245407-51245432 (+)	212 bp
Tssr125394	Chr14:51246473-51246484 (+)	1,271 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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